3156 |
3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE |
HMGCR |
LDLCQ3 |
142910 |
5006 |
ENSG00000113161 |
OTTHUMG00000102069 |
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (EC 1.1.1.34) (HMG-COA REDUCTASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04035] |
HMG-CoA reductase |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
P04035 |
HMDH_HUMAN |
639 |
hydroxymethylglutaryl-CoA reductase |
BE0000574 |
PA189 |
T53585 |
NM_000859|NM_001130996 |
NP_000850|NP_001124468 |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | HMG_CoA_Rdtase |
Interpro Type | Family |
Interpro Name | Hydroxymethylglutaryl-CoA reductase, class I/II |
Interpro Acc | IPR002202 |
Uniprot Status | Swiss-Prot |
Target Class | Enzymes |
Target Subclass | EC:1.1.1.34 |
Transmembrane Helix Count | 8 |
Target Subclass | 1.1 |
Target Main Class | Enzymes |
Gene Biotype | PROTEIN_CODING |
GuideToPharmacology Gene Category Name | Lanosterol biosynthesis pathway |
GuideToPharmacology Gene Category ID | 104 |
DRUGGABLE GENOME |
ENZYME |
inhibitor (inhibitory) |
Details of the Assay for Interaction | Inhibition of HMG-CoA reductase |
Specific Action of the Ligand | Competitive |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Mechanism of Interaction | HMG-CoA reductase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | pitavastatin , NK-104,Livalo |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | HMG-CoA reductase inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | HMG-CoA reductase inhibitor |
inhibitor (inhibitory) |
Specific Action of the Ligand | Competitive |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | fluvastatin sodium,Lescol and Lescol XL |
Details of the Assay for Interaction | Inhibition of HMG-CoA reductase |
inhibitor (inhibitory) |
Trial Name | lovastatin,Mevacor, Altocor, Altoprev |
Novel drug target | Established target |
Mechanism of Interaction | HMG-CoA reductase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | HMG-CoA reductase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | HMG-CoA reductase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | HMG-CoA reductase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | CRES pravastatin |
Novel drug target | Established target |
Trial Name | pravastatin and fenofibrate,PravaFen |
inhibitor (inhibitory) |
Trial Name | HL 007, simvastatin + amlodipine |
Novel drug target | Established target |
Trial Name | MK-0542B, extended release niacin + laropiprant +simvastatin |
inhibitor (inhibitory) |
Details of the Assay for Interaction | In vitro inhibition of HMG-CoA reductase |
Specific Action of the Ligand | Competitive |
Endogenous Drug? | False |
HMGCR | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000113161 | Ensembl Gene Id |
HMGCR | Display Id |
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (EC 1.1.1.34) (HMG-COA REDUCTASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P04035] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
HMDH_HUMAN | Uniprot Id |
P04035 | Uniprot Accession |
3156 | Entrez Gene Id |
Transmembrane Helix Count | 8 |
Target Subclass | 1.1 |
Target Main Class | Enzymes |
HMGCR | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:1.1.1.34 |
HMDH_HUMAN | Uniprot Id |
HMGCR | Uniprot Gene Name |
P04035 | Uniprot Accession |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | HMG_CoA_Rdtase |
DRUGGABLE GENOME |
5006 | HUGO Gene ID |
5006 | HUGO Gene Symbol |
3-hydroxy-3-methylglutaryl-CoA reductase | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Lanosterol biosynthesis pathway |
GuideToPharmacology Gene Category ID | 104 |
ENZYME |
PA189 | PharmGKB ID |
HMGCR | DrugBank Gene Name |
P04035 | UniProt Accession |
3156 | Entrez Gene Id |
ENSG00000113161 | Gene Symbol |
HMGCR | Ensembl Id |
DRUGGABLE GENOME |
HMGCR | GENE_SYMBOL |
3-hydroxy-3-methylglutaryl-coenzyme A reductase | UNIPROT |
HMG-CoA reductase | UNIPROT |
3-hydroxy-3-methylglutaryl-coenzyme A reductase | Gene Name |
P04035 | UniProt ID |
ENZYME |
HMGCR | TTD Gene Abbreviation |
T53585 | TTD Target ID |