DGIdb - HMGB1 Gene Record

HMGB1 3146 Druggable Genome

Alternate Names:

3146
HIGH MOBILITY GROUP BOX 1
HMGB1
HMG-1
HMG1
HMG3
SBP-1
163905
4983
ENSG00000189403
OTTHUMG00000016670
P09429
HMGB1_HUMAN
BE0003428
High mobility group protein B1
T63595

Gene Info:

Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

CELL SURFACE
DNA REPAIR
KINASE
PROTEASE
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Furugen et al., 2008, Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone., Respir. Res.
Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.
Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene
Li et al., 2007, A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1., PLoS ONE
Webster et al., 1997, High mobility group proteins HMG-1 and HMG-I/Y bind to a positive regulatory region of the pea plastocyanin gene promoter., Plant J.
Melloni et al., 1995, Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain., Biochem. Biophys. Res. Commun.
Patrick et al., 1997, High-mobility group 1 protein inhibits helicase catalyzed displacement of cisplatin-damaged DNA., Biochim. Biophys. Acta
Kawahara et al., 1996, Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin., Cancer Res.
Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.
Nissen et al., 1991, Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein., J. Biol. Chem.
Narimatsu et al., 2003, [Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia]., Rinsho Ketsueki
Yang M et al., 2013, Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis., Biochem Pharmacol

CHLOROQUINE HMGB1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Yang M et al., 2013, Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis., Biochem Pharmacol

PREDNISOLONE HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Furugen et al., 2008, Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone., Respir. Res.

SODIUM CHLORIDE HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.

CHLORAMPHENICOL HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene

EPIGALOCATECHIN GALLATE HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Li et al., 2007, A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1., PLoS ONE

AMPICILLIN HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene

ANTIBIOTIC HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Webster et al., 1997, High mobility group proteins HMG-1 and HMG-I/Y bind to a positive regulatory region of the pea plastocyanin gene promoter., Plant J.

HEXAMETHYLENEBISACETAMIDE HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Melloni et al., 1995, Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain., Biochem. Biophys. Res. Commun.

CISPLATIN HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Patrick et al., 1997, High-mobility group 1 protein inhibits helicase catalyzed displacement of cisplatin-damaged DNA., Biochim. Biophys. Acta

Kawahara et al., 1996, Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin., Cancer Res.

UREA HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.
VOLANESORSEN SODIUM HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nissen et al., 1991, Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein., J. Biol. Chem.
ITRACONAZOLE HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Narimatsu et al., 2003, [Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia]., Rinsho Ketsueki
ETHYL PYRUVATE HMGB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000189403
- Version: 101_38
Alternate Names:

HMGB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
DrugBank: BE0003428
- Version: 5.1.7
Alternate Names:

HMGB1 DrugBank Gene Name

P09429 UniProt Accession

3146 Entrez Gene Id

Gene Info:

Publications:

Yang M et al., 2013, Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis., Biochem Pharmacol

NCI: HMGB1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.

Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene

Melloni et al., 1995, Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain., Biochem. Biophys. Res. Commun.

HingoraniCasas: ENSG00000189403
- Version: 31-May-2017
Alternate Names:

ENSG00000189403 Gene Symbol

HMGB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: High mobility group protein B1
- Version: 2020.06.01
Alternate Names:

HMGB1 TTD Gene Abbreviation

T63595 TTD Target ID

Gene Info:

Publications:
Pharos: HMGB1
- Version: 03-September-2020
Alternate Names:

High mobility group protein B1 Gene Name

P09429 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
GO: HMGB1
- Version: 05-September-2020
Alternate Names:

HMG1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, TRANSCRIPTION FACTOR BINDING

Publications:

HMGB1	DrugBank Gene Name
P09429	UniProt Accession
3146	Entrez Gene Id

HMGB1 Gene Record

HMGB1 3146 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Yang M et al., 2013, Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis., Biochem Pharmacol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Furugen et al., 2008, Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone., Respir. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Li et al., 2007, A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1., PLoS ONE

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Webster et al., 1997, High mobility group proteins HMG-1 and HMG-I/Y bind to a positive regulatory region of the pea plastocyanin gene promoter., Plant J.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Melloni et al., 1995, Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain., Biochem. Biophys. Res. Commun.

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Nissen et al., 1991, Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein., J. Biol. Chem.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Narimatsu et al., 2003, [Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia]., Rinsho Ketsueki

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Ensembl: ENSG00000189403

Alternate Names: HMGB1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

DrugBank: BE0003428

Alternate Names: HMGB1 DrugBank Gene Name P09429 UniProt Accession 3146 Entrez Gene Id

Gene Info:

Publications: Yang M et al., 2013, Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis., Biochem Pharmacol

NCI: HMGB1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000189403

Alternate Names: ENSG00000189403 Gene Symbol HMGB1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: High mobility group protein B1

Alternate Names: HMGB1 TTD Gene Abbreviation T63595 TTD Target ID

Gene Info:

Publications:

Pharos: HMGB1

Alternate Names: High mobility group protein B1 Gene Name P09429 UniProt ID

Gene Info:

Gene Categories: TRANSCRIPTION FACTOR

Publications:

GO: HMGB1

Alternate Names: HMG1 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, TRANSCRIPTION FACTOR BINDING

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Yang M et al., 2013, Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis., Biochem Pharmacol

Interaction Types & Directionality:

n/a

Publications:

Furugen et al., 2008, Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone., Respir. Res.

Interaction Types & Directionality:

n/a

Publications:

Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.

Interaction Types & Directionality:

n/a

Publications:

Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene

Interaction Types & Directionality:

n/a

Publications:

Li et al., 2007, A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1., PLoS ONE

Interaction Types & Directionality:

n/a

Publications:

Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene

Interaction Types & Directionality:

n/a

Publications:

Webster et al., 1997, High mobility group proteins HMG-1 and HMG-I/Y bind to a positive regulatory region of the pea plastocyanin gene promoter., Plant J.

Interaction Types & Directionality:

n/a

Publications:

Melloni et al., 1995, Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain., Biochem. Biophys. Res. Commun.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.

Interaction Types & Directionality:

n/a

Publications:

Nissen et al., 1991, Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein., J. Biol. Chem.

Interaction Types & Directionality:

n/a

Publications:

Narimatsu et al., 2003, [Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia]., Rinsho Ketsueki

Interaction Types & Directionality:

n/a

Alternate Names:

HMGB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

HMGB1 DrugBank Gene Name

P09429 UniProt Accession

3146 Entrez Gene Id

Publications:

Yang M et al., 2013, Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis., Biochem Pharmacol

Alternate Names:

ENSG00000189403 Gene Symbol

HMGB1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HMGB1 TTD Gene Abbreviation

T63595 TTD Target ID

Alternate Names:

High mobility group protein B1 Gene Name

P09429 UniProt ID

Gene Categories:

TRANSCRIPTION FACTOR

Alternate Names:

HMG1 GO Gene Synonym

Gene Categories:

CELL SURFACE, TRANSCRIPTION FACTOR BINDING