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HMGB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • HMGB1 3146 Druggable Genome

    Alternate Names:

    3146
    HIGH MOBILITY GROUP BOX 1
    HMGB1
    HMG-1
    HMG1
    HMG3
    SBP-1
    163905
    4983
    ENSG00000189403
    OTTHUMG00000016670
    P09429
    High mobility group protein B1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Furugen et al., 2008, Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone., Respir. Res.
    Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.
    Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene
    Li et al., 2007, A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1., PLoS ONE
    Webster et al., 1997, High mobility group proteins HMG-1 and HMG-I/Y bind to a positive regulatory region of the pea plastocyanin gene promoter., Plant J.
    Melloni et al., 1995, Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain., Biochem. Biophys. Res. Commun.
    Patrick et al., 1997, High-mobility group 1 protein inhibits helicase catalyzed displacement of cisplatin-damaged DNA., Biochim. Biophys. Acta
    Kawahara et al., 1996, Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin., Cancer Res.
    Vartiainen et al., 1988, Selective decrease in low-Mr HMG proteins HMG I and HMG Y during differentiation of mouse teratocarcinoma cells., FEBS Lett.
    Nissen et al., 1991, Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein., J. Biol. Chem.
    Narimatsu et al., 2003, [Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia]., Rinsho Ketsueki
  • HEXAMETHYLENEBISACETAMIDE   HMGB1

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7741753


    Sources:
    NCI

  • CHLORAMPHENICOL   HMGB1

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9931456


    Sources:
    NCI

  • UREA   HMGB1

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3342876


    Sources:
    NCI

  • ITRACONAZOLE   HMGB1

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14639950


    Sources:
    NCI

  • ANTIBIOTIC   HMGB1

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9161031


    Sources:
    NCI

  • AMPICILLIN   HMGB1

    Interaction Score: 1.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9931456


    Sources:
    NCI

  • VOLANESORSEN SODIUM   HMGB1

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1939057


    Sources:
    NCI

  • SODIUM CHLORIDE   HMGB1

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17334244


    Sources:
    NCI

  • PREDNISOLONE   HMGB1

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18447956


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   HMGB1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17987129


    Sources:
    NCI

  • CISPLATIN   HMGB1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9427537 8968078


    Sources:
    NCI

  • Ensembl: ENSG00000189403

    • Version: 101_38

    Alternate Names:
    HMGB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: HMGB1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Pavlov et al., 2007, Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis., Crit. Care Med.
    Lee et al., 1998, Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli., Gene
    Melloni et al., 1995, Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain., Biochem. Biophys. Res. Commun.

  • HingoraniCasas: ENSG00000189403

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000189403 Gene Symbol
    HMGB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: HMGB1

    • Version: 01-February-2022

    Alternate Names:
    HMG1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • Pharos: HMGB1

    • Version: 01-February-2022

    Alternate Names:
    High mobility group protein B1 Gene Name
    P09429 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21