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HLA-DRB5 Gene Record

  • Summary
  • Interactions
  • Claims
  • HLA-DRB5 3127 Druggable Genome

    Alternate Names:

    3127
    MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA 5
    HLA-DRB5
    604776
    4953
    ENSG00000198502
    OTTHUMG00000031027
    P13762
    PA35076
    HLA-DRB5*

    Gene Info:

    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion
    Target Subclass MHC claas II
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Hautekeete ML et al., 1999, HLA association of amoxicillin-clavulanate--induced hepatitis., Gastroenterology
    Dettling M et al., 2001, Genetic determinants of clozapine-induced agranulocytosis: recent results of HLA subtyping in a non-jewish caucasian sample., Arch Gen Psychiatry
  • 1D09C3   HLA-DRB5

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name 1D09C3
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • CLAVULANIC ACID   HLA-DRB5

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10535882


    Sources:
    PharmGKB

  • AMOXICILLIN   HLA-DRB5

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10535882


    Sources:
    PharmGKB

  • CLOZAPINE   HLA-DRB5

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11146763


    Sources:
    PharmGKB

  • Ensembl: ENSG00000198502

    • Version: 101_38

    Alternate Names:
    HLA-DRB5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P13762

    • Version: January-2014

    Alternate Names:
    HLA-DRB5 Gene Symbol

    Gene Info:
    Target Subclass MHC claas II
    Target Class Miscellaneous
    Target Subclass StructuralAndAdhesion

    Publications:

  • PharmGKB: HLA-DRB5

    • Version: 18-August-2020

    Alternate Names:
    PA35076 PharmGKB ID

    Gene Info:

    Publications:
    Hautekeete ML et al., 1999, HLA association of amoxicillin-clavulanate--induced hepatitis., Gastroenterology
    Dettling M et al., 2001, Genetic determinants of clozapine-induced agranulocytosis: recent results of HLA subtyping in a non-jewish caucasian sample., Arch Gen Psychiatry

  • HingoraniCasas: ENSG00000198502

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000198502 Gene Symbol
    HLA-DRB5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Tempus: HLA-DRB5

    • Version: 11-November-2018

    Alternate Names:
    HLA-DRB5 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21