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HLA-A Gene Record

  • Summary
  • Interactions
  • Claims
  • HLA-A 3105 Druggable Genome

    Alternate Names:

    3105
    MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A
    HLA-A
    HLAA
    142800
    4931
    ENSG00000206503
    OTTHUMG00000130501
    PA35055

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME

    Publications:

    Kaniwa N et al., 2013, Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects., Pharmacogenomics
    Hirata K et al., 2008, Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study., Pharmacogenomics J
    Farag RE et al., 2013, Human leukocyte antigen class I alleles can predict response to pegylated interferon/ribavirin therapy in chronic hepatitis C Egyptian patients., Arch Iran Med
    Nakkam N et al., 2020, Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01-positive vancomycin-induced DRESS sharing an HLA class II haplotype., J Allergy Clin Immunol
    Yang TW et al., 2018, HLA-A*11:01 is associated with levetiracetam-induced psychiatric adverse events., PLoS One
    Yue Z et al., 2018, Amino Acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity Syndrome in Addition to HLA-B*13:01., J Invest Dermatol
    Romano A et al., 1998, Delayed hypersensitivity to aminopenicillins is related to major histocompatibility complex genes., Ann Allergy Asthma Immunol
  • BACAMPICILLIN   HLA-A

    Interaction Score: 8.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9609616


    Sources:
    PharmGKB

  • VANCOMYCIN   HLA-A

    Interaction Score: 8.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32439433


    Sources:
    PharmGKB

  • IPILIMUMAB   HLA-A

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TERBINAFINE   HLA-A

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LEVETIRACETAM   HLA-A

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30020991


    Sources:
    PharmGKB

  • DAPSONE   HLA-A

    Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29233746


    Sources:
    PharmGKB

  • AMPICILLIN   HLA-A

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9609616


    Sources:
    PharmGKB

  • TICLOPIDINE   HLA-A

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17339877


    Sources:
    PharmGKB

  • CLAVULANIC ACID   HLA-A

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMOXICILLIN   HLA-A

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9609616


    Sources:
    PharmGKB

  • ZONISAMIDE   HLA-A

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24236482


    Sources:
    PharmGKB

  • RIBAVIRIN   HLA-A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23360626


    Sources:
    PharmGKB

  • SERTRALINE   HLA-A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FENOFIBRATE   HLA-A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CARBAMAZEPINE   HLA-A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • Ensembl: ENSG00000206503

    • Version: 101_38

    Alternate Names:
    HLA-A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: HLA-A

    • Version: 18-August-2020

    Alternate Names:
    PA35055 PharmGKB ID

    Gene Info:

    Publications:
    Yue Z et al., 2018, Amino Acid Variants of HLA-DRB1 Confer Susceptibility to Dapsone Hypersensitivity Syndrome in Addition to HLA-B*13:01., J Invest Dermatol
    Romano A et al., 1998, Delayed hypersensitivity to aminopenicillins is related to major histocompatibility complex genes., Ann Allergy Asthma Immunol
    Farag RE et al., 2013, Human leukocyte antigen class I alleles can predict response to pegylated interferon/ribavirin therapy in chronic hepatitis C Egyptian patients., Arch Iran Med

  • NCI: HLA-A

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Madsen et al., 1981, Decreased expression of HLA-DR antigens on peripheral blood B lymphocytes during glucocorticoid treatment., Tissue Antigens
    Hoon et al., 1998, Is the survival of melanoma patients receiving polyvalent melanoma cell vaccine linked to the human leukocyte antigen phenotype of patients?, J. Clin. Oncol.
    Fischer et al., 1984, HLA -A, -B, -C and -DR antigens in individuals with sensitivity to cobalt., Acta Derm. Venereol.

  • HingoraniCasas: ENSG00000206503

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000206503 Gene Symbol
    HLA-A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: HLA-A

    • Version: 01-February-2022

    Alternate Names:
    HLAA GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • Tempus: HLA-A

    • Version: 11-November-2018

    Alternate Names:
    HLA-A Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FDA: HLA-A

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21