DGIdb - HGF Gene Record

HGF 3082 Druggable GenomeClinically Actionable

Alternate Names:

3082
HEPATOCYTE GROWTH FACTOR
HGF
DFNB39
F-TCF
HGFB
HPTA
SF
142409
4893
ENSG00000019991
OTTHUMG00000023804
Hepatopoietin-A
Hepatocyte growth factor beta chain
Hepatocyte growth factor alpha chain
Scatter factor
P14210
HGF_HUMAN
HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A). [SOURCE:UNIPROT/SWISSPROT;ACC:P14210]
T83797

Gene Info:

Human Readable Name	PROTEASE
CancerCommons Reported Gene Name	HGF (MET Ligand)
Target Class	Ligand
Target Subclass	Ligand
Target Subclass	HGF
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Peptidase S1/S6, chymotrypsin/Hap
Interpro Short Name	Peptidase_S1_S6
Interpro Acc	IPR001254
Interpro Type	Domain
Gene Biotype	PROTEIN_CODING

(15 More Sources)

Gene Categories: Category Details

KINASE
GROWTH FACTOR
PROTEASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Frasca et al., 2001, Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor., Oncogene
Vacca et al., 2005, Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma., J. Clin. Oncol.
Abiru et al., 2002, Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells., Hepatology
Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis
Kotelevets et al., 1998, Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion., J. Biol. Chem.
Garcia-Ocana et al., 2003, Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death., J. Biol. Chem.
Xian et al., 2000, Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis., Br. J. Cancer
Bigelow et al., 2006, The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells., Oncogene
Cantarella et al., 2005, Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat., Eur. J. Pharmacol.

FICLATUZUMAB HGF

Interaction Score: 12.88

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name AV-299, SCH900105

Novel drug target Novel Target

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
RILOTUMUMAB HGF

Interaction Score: 12.88

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name AMG-102

Novel drug target Novel Target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons
MP-0250 HGF

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
IMATINIB MESYLATE HGF

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11439348

Sources:
NCI
RESERPINE HGF

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16081063

Sources:
NCI
EPIGALOCATECHIN GALLATE HGF

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16449979

Sources:
NCI
WORTMANNIN HGF

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9603913

Sources:
NCI
THALIDOMIDE HGF

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15939924

Sources:
NCI
STREPTOZOCIN HGF

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12403787

Sources:
NCI
RESVERATROL HGF

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15672869

Sources:
NCI
ASPIRIN HGF

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11981761

Sources:
NCI
METHOTREXATE HGF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10732770

Sources:
NCI

Ensembl: ENSG00000019991
- Version: 101_38
Alternate Names:

HGF Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000019991
- Version: 26-July-2011
Alternate Names:

HGF Display Id

HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A). [SOURCE:UNIPROT/SWISSPROT;ACC:P14210] Description

ENSG00000019991 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
CancerCommons: HGF
- Version: 25-July-2013
Alternate Names:

3082 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name HGF (MET Ligand)

Publications:
TdgClinicalTrial: P14210
- Version: January-2014
Alternate Names:

HGF Gene Symbol

Gene Info:

Target Class Ligand

Target Subclass Ligand

Target Subclass HGF

Publications:
HopkinsGroom: P14210
- Version: 11-September-2012
Alternate Names:

HGF Uniprot Gene Name

P14210 Uniprot Accession

3082 Entrez Gene Id

Gene Info:

Human Readable Name PROTEASE

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:

NCI: HGF

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Frasca et al., 2001, Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor., Oncogene

Vacca et al., 2005, Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma., J. Clin. Oncol.

Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis

HingoraniCasas: ENSG00000019991
- Version: 31-May-2017
Alternate Names:

ENSG00000019991 Gene Symbol

HGF Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: HGF
- Version: 12-May-2016
Alternate Names:

HGF Gene Symbol

Gene Info:

Publications:
MyCancerGenome: HGF
- Version: 20-Jun-2017
Alternate Names:

3082 Entrez Gene Id

HGF MyCancerGenome Gene Symbol

HGF MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: HPTA
- Version: chembl_23
Alternate Names:

HPTA GENE_SYMBOL

HGF GENE_SYMBOL

Hepatocyte growth factor UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: HGF
- Version: 19.3
Alternate Names:

ENSG00000019991 Ensembl Gene ID

DFNB39 Human Protein Atlas Gene Synonym

F-TCF Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: HGF
- Version: 01-February-2022
Alternate Names:

HPTA GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:
Tempus: HGF
- Version: 11-November-2018
Alternate Names:

HGF Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: HGF
- Version: 27-Jun-2013
Alternate Names:

3082 Gene ID

DFNB39 dGene Synonym

F-TCF dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Hepatocyte growth factor
- Version: 2020.06.01
Alternate Names:

HGF TTD Gene Abbreviation

T83797 TTD Target ID

Gene Info:

Publications:
Pharos: HGF
- Version: 01-February-2022
Alternate Names:

Hepatocyte growth factor Gene Name

P14210 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: HGF
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: HGF
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: HGF
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Trial Name	AV-299, SCH900105
Novel drug target	Novel Target
Notes

HGF	Display Id
HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A). [SOURCE:UNIPROT/SWISSPROT;ACC:P14210]	Description
ENSG00000019991	Ensembl Gene Id

HGF	Uniprot Gene Name
P14210	Uniprot Accession
3082	Entrez Gene Id

3082	Entrez Gene Id
HGF	MyCancerGenome Gene Symbol
HGF	MyCancerGenome Reported Gene Name

HPTA	GENE_SYMBOL
HGF	GENE_SYMBOL
Hepatocyte growth factor	UNIPROT

antibody (inhibitory)
inhibitor (inhibitory)

antibody (inhibitory)
inhibitor (inhibitory)

HGF Gene Record

HGF 3082 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name AV-299, SCH900105 Novel drug target Novel Target Notes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Notes Trial Name AMG-102 Novel drug target Novel Target

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11439348

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16081063

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16449979

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9603913

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15939924

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12403787

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15672869

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11981761

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10732770

Sources: NCI

Ensembl: ENSG00000019991

Alternate Names: HGF Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000019991

Alternate Names: HGF Display Id HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A). [SOURCE:UNIPROT/SWISSPROT;ACC:P14210] Description ENSG00000019991 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

CancerCommons: HGF

Alternate Names: 3082 Entrez Gene ID

Gene Info: CancerCommons Reported Gene Name HGF (MET Ligand)

Publications:

TdgClinicalTrial: P14210

Alternate Names: HGF Gene Symbol

Gene Info: Target Class Ligand Target Subclass Ligand Target Subclass HGF

Publications:

HopkinsGroom: P14210

Alternate Names: HGF Uniprot Gene Name P14210 Uniprot Accession 3082 Entrez Gene Id

Gene Info: Human Readable Name PROTEASE Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level

Gene Categories: PROTEASE, DRUGGABLE GENOME

Publications:

NCI: HGF

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000019991

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name AV-299, SCH900105

Novel drug target Novel Target

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name AMG-102

Novel drug target Novel Target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
11439348

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16081063

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16449979

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9603913

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15939924

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12403787

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15672869

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11981761

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10732770

Sources:
NCI

Alternate Names:

HGF Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

HGF Display Id

HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A). [SOURCE:UNIPROT/SWISSPROT;ACC:P14210] Description

ENSG00000019991 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

3082 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name HGF (MET Ligand)

Alternate Names:

HGF Gene Symbol

Gene Info:

Target Class Ligand

Target Subclass Ligand

Target Subclass HGF

Alternate Names:

HGF Uniprot Gene Name

P14210 Uniprot Accession

3082 Entrez Gene Id

Gene Info:

Human Readable Name PROTEASE

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

ENSG00000019991 Gene Symbol

HGF Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HGF Gene Symbol

Alternate Names:

3082 Entrez Gene Id

HGF MyCancerGenome Gene Symbol

HGF MyCancerGenome Reported Gene Name

Alternate Names:

HPTA GENE_SYMBOL

HGF GENE_SYMBOL

Hepatocyte growth factor UNIPROT

Alternate Names:

ENSG00000019991 Ensembl Gene ID

DFNB39 Human Protein Atlas Gene Synonym

F-TCF Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

HPTA GO Gene Synonym

Gene Categories:

GROWTH FACTOR

Alternate Names:

HGF Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

3082 Gene ID

DFNB39 dGene Synonym

F-TCF dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

HGF TTD Gene Abbreviation

T83797 TTD Target ID

Alternate Names:

Hepatocyte growth factor Gene Name

P14210 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE