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HGF Gene Record

  • Summary
  • Interactions
  • Claims
  • HGF 3082 Druggable GenomeClinically Actionable

    Alternate Names:

    3082
    HEPATOCYTE GROWTH FACTOR
    HGF
    DFNB39
    F-TCF
    HGFB
    HPTA
    SF
    142409
    4893
    ENSG00000019991
    OTTHUMG00000023804
    Hepatopoietin-A
    Hepatocyte growth factor beta chain
    Hepatocyte growth factor alpha chain
    Scatter factor
    P14210
    HGF_HUMAN
    HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A). [SOURCE:UNIPROT/SWISSPROT;ACC:P14210]
    T83797

    Gene Info:

    Human Readable Name PROTEASE
    CancerCommons Reported Gene Name HGF (MET Ligand)
    Target Class Ligand
    Target Subclass Ligand
    Target Subclass HGF
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Interpro Short Name Peptidase_S1_S6
    Interpro Acc IPR001254
    Interpro Type Domain
    Gene Biotype PROTEIN_CODING
    (15 More Sources)

    Gene Categories: Category Details

    KINASE
    GROWTH FACTOR
    PROTEASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Frasca et al., 2001, Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor., Oncogene
    Vacca et al., 2005, Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma., J. Clin. Oncol.
    Abiru et al., 2002, Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells., Hepatology
    Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis
    Kotelevets et al., 1998, Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion., J. Biol. Chem.
    Garcia-Ocana et al., 2003, Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death., J. Biol. Chem.
    Xian et al., 2000, Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis., Br. J. Cancer
    Bigelow et al., 2006, The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells., Oncogene
    Cantarella et al., 2005, Adrenomedullin modulates COX-2 and HGF expression in reserpine-injuried gastric mucosa in the rat., Eur. J. Pharmacol.
  • FICLATUZUMAB   HGF

    Interaction Score: 12.88

    Interaction Types & Directionality:
    antibody (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name AV-299, SCH900105
    Novel drug target Novel Target
    Notes

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

  • RILOTUMUMAB   HGF

    Interaction Score: 12.88

    Interaction Types & Directionality:
    antibody (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name AMG-102
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons

  • MP-0250   HGF

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • IMATINIB MESYLATE   HGF

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11439348


    Sources:
    NCI

  • RESERPINE   HGF

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16081063


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   HGF

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16449979


    Sources:
    NCI

  • WORTMANNIN   HGF

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9603913


    Sources:
    NCI

  • THALIDOMIDE   HGF

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15939924


    Sources:
    NCI

  • STREPTOZOCIN   HGF

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12403787


    Sources:
    NCI

  • RESVERATROL   HGF

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15672869


    Sources:
    NCI

  • ASPIRIN   HGF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11981761


    Sources:
    NCI

  • METHOTREXATE   HGF

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10732770


    Sources:
    NCI

  • Ensembl: ENSG00000019991

    • Version: 101_38

    Alternate Names:
    HGF Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000019991

    • Version: 26-July-2011

    Alternate Names:
    HGF Display Id
    HEPATOCYTE GROWTH FACTOR PRECURSOR (SCATTER FACTOR) (SF) (HEPATOPOEITIN A). [SOURCE:UNIPROT/SWISSPROT;ACC:P14210] Description
    ENSG00000019991 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • CancerCommons: HGF

    • Version: 25-July-2013

    Alternate Names:
    3082 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name HGF (MET Ligand)

    Publications:

  • TdgClinicalTrial: P14210

    • Version: January-2014

    Alternate Names:
    HGF Gene Symbol

    Gene Info:
    Target Class Ligand
    Target Subclass Ligand
    Target Subclass HGF

    Publications:

  • HopkinsGroom: P14210

    • Version: 11-September-2012

    Alternate Names:
    HGF Uniprot Gene Name
    P14210 Uniprot Accession
    3082 Entrez Gene Id

    Gene Info:
    Human Readable Name PROTEASE
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • NCI: HGF

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Frasca et al., 2001, Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor., Oncogene
    Vacca et al., 2005, Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma., J. Clin. Oncol.
    Miura et al., 2004, Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property., Clin. Exp. Metastasis

  • HingoraniCasas: ENSG00000019991

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000019991 Gene Symbol
    HGF Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: HGF

    • Version: 12-May-2016

    Alternate Names:
    HGF Gene Symbol

    Gene Info:

    Publications:

  • MyCancerGenome: HGF

    • Version: 20-Jun-2017

    Alternate Names:
    3082 Entrez Gene Id
    HGF MyCancerGenome Gene Symbol
    HGF MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • ChemblInteractions: HPTA

    • Version: chembl_23

    Alternate Names:
    HPTA GENE_SYMBOL
    HGF GENE_SYMBOL
    Hepatocyte growth factor UNIPROT

    Gene Info:

    Publications:

  • HumanProteinAtlas: HGF

    • Version: 19.3

    Alternate Names:
    ENSG00000019991 Ensembl Gene ID
    DFNB39 Human Protein Atlas Gene Synonym
    F-TCF Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: HGF

    • Version: 01-February-2022

    Alternate Names:
    HPTA GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

  • Tempus: HGF

    • Version: 11-November-2018

    Alternate Names:
    HGF Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: HGF

    • Version: 27-Jun-2013

    Alternate Names:
    3082 Gene ID
    DFNB39 dGene Synonym
    F-TCF dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Hepatocyte growth factor

    • Version: 2020.06.01

    Alternate Names:
    HGF TTD Gene Abbreviation
    T83797 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: HGF

    • Version: 01-February-2022

    Alternate Names:
    Hepatocyte growth factor Gene Name
    P14210 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: HGF

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: HGF

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: HGF

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21