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HEXB Gene Record

  • Summary
  • Interactions
  • Claims
  • HEXB 3074

    Alternate Names:

    3074
    HEXOSAMINIDASE SUBUNIT BETA
    HEXB
    ENC-1AS
    HEL-248
    HEL-S-111
    606873
    4879
    ENSG00000049860
    OTTHUMG00000102057
    P07686
    Beta-hexosaminidase subunit beta

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    ENZYME

    Publications:

    Toimela et al., 1995, Retinal pigment epithelium cell culture as a model for evaluation of the toxicity of tamoxifen and chloroquine., Ophthalmic Res.
    Peterson et al., 1981, Intracellular localization of estramustine in rat ventral prostate in vitro., Prostate
    Fujisaki et al., 1998, Effects of rabeprazole, a gastric proton pump inhibitor, on biliary and hepatic lysosomal enzymes in rats., Jpn. J. Pharmacol.
    Eti et al., 1993, Urinary clusterin in chronic nephrotoxicity in the rat., Proc. Soc. Exp. Biol. Med.
    Regec et al., 1986, The effect of gentamicin on human renal proximal tubular cells., Toxicol Pathol
    Kim EJ et al., 2010, OGA inhibition by GlcNAc-selenazoline., Bioorg Med Chem
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Shirasaka, 1990, [Clinical study of nephrotoxicity following cis-diamminedichloroplatinum (II) (CDDP) combination chemotherapy assessed by 131I-OIH renogram]., Nihon Igaku Hoshasen Gakkai Zasshi
    Oberkotter et al., 1980, Effects of cortisone and thyroxine on suckling rat liver N-acetyl-beta-glucosaminidase isozymes. Comparison with adult reactivity., Biochim. Biophys. Acta
  • CHEMBL257158   HEXB

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20822912 17139284 17016423


    Sources:
    DTC

  • CORTISONE   HEXB

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7388056


    Sources:
    NCI

  • ESTRAMUSTINE   HEXB

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6795611


    Sources:
    NCI

  • RABEPRAZOLE   HEXB

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9593221


    Sources:
    NCI

  • THYROXINE   HEXB

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7388056


    Sources:
    NCI

  • GENTAMICIN   HEXB

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8456116 2876489


    Sources:
    NCI

  • OMEPRAZOLE   HEXB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9593221


    Sources:
    NCI

  • TAMOXIFEN   HEXB

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8577454


    Sources:
    NCI

  • CISPLATIN   HEXB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2089371


    Sources:
    NCI

  • Ensembl: ENSG00000049860

    • Version: 101_38

    Alternate Names:
    HEXB Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: HEXB

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Fujita et al., 1987, Comparison of the effect of aminoglycosides on excretion of N-acetyl-beta-glucosaminidase., Int J Clin Pharmacol Res
    Toimela et al., 1995, Retinal pigment epithelium cell culture as a model for evaluation of the toxicity of tamoxifen and chloroquine., Ophthalmic Res.
    Oberkotter et al., 1980, Effects of cortisone and thyroxine on suckling rat liver N-acetyl-beta-glucosaminidase isozymes. Comparison with adult reactivity., Biochim. Biophys. Acta

  • DTC: HEXB

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kim EJ et al., 2010, OGA inhibition by GlcNAc-selenazoline., Bioorg Med Chem

  • HumanProteinAtlas: HEXB

    • Version: 19.3

    Alternate Names:
    ENSG00000049860 Ensembl Gene ID
    Hexosaminidase subunit beta Human Protein Atlas Gene Description
    P07686 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: HEXB

    • Version: 01-February-2022

    Alternate Names:
    Beta-hexosaminidase subunit beta Gene Name
    P07686 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21