DGIdb - HEXA Gene Record

HEXA 3073 Druggable Genome

Alternate Names:

3073
HEXOSAMINIDASE SUBUNIT ALPHA
HEXA
TSD
606869
4878
ENSG00000213614
OTTHUMG00000133445
P06865
Beta-hexosaminidase subunit alpha

Gene Info:

Gene Biotype	PROTEIN_CODING

(1 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Kim EJ et al., 2010, OGA inhibition by GlcNAc-selenazoline., Bioorg Med Chem
Tropak MB et al., 2015, Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity., J Med Chem
Maegawa GH et al., 2007, Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis., J Biol Chem

CHEMBL22148 HEXA

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25984755

Sources:
DTC
ECHINOMYCIN HEXA

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIOCORALINE HEXA

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL257158 HEXA

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20822912

Sources:
DTC
PYRIMETHAMINE HEXA

Interaction Score: 3.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17237499 25984755

Sources:
DTC

Ensembl: ENSG00000213614
- Version: 101_38
Alternate Names:

HEXA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

DTC: HEXA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Tropak MB et al., 2015, Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity., J Med Chem

Maegawa GH et al., 2007, Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis., J Biol Chem

Kim EJ et al., 2010, OGA inhibition by GlcNAc-selenazoline., Bioorg Med Chem

HingoraniCasas: ENSG00000213614
- Version: 31-May-2017
Alternate Names:

ENSG00000213614 Gene Symbol

HEXA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: HEXA
- Version: 19.3
Alternate Names:

ENSG00000213614 Ensembl Gene ID

Hexosaminidase subunit alpha Human Protein Atlas Gene Description

P06865 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: HEXA
- Version: 01-February-2022
Alternate Names:

Beta-hexosaminidase subunit alpha Gene Name

P06865 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ENSG00000213614	Ensembl Gene ID
Hexosaminidase subunit alpha	Human Protein Atlas Gene Description
P06865	UniProt ID

HEXA Gene Record

HEXA 3073 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL22148 HEXA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25984755

Sources: DTC

ECHINOMYCIN HEXA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

THIOCORALINE HEXA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

CHEMBL257158 HEXA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20822912

Sources: DTC

PYRIMETHAMINE HEXA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17237499 25984755

Sources: DTC

Ensembl: ENSG00000213614

Alternate Names: HEXA Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

DTC: HEXA

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000213614

Alternate Names: ENSG00000213614 Gene Symbol HEXA Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: HEXA

Alternate Names: ENSG00000213614 Ensembl Gene ID Hexosaminidase subunit alpha Human Protein Atlas Gene Description P06865 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: HEXA

Alternate Names: Beta-hexosaminidase subunit alpha Gene Name P06865 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
25984755

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20822912

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17237499 25984755

Sources:
DTC

Alternate Names:

HEXA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000213614 Gene Symbol

HEXA Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000213614 Ensembl Gene ID

Hexosaminidase subunit alpha Human Protein Atlas Gene Description

P06865 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

Beta-hexosaminidase subunit alpha Gene Name

P06865 UniProt ID

Gene Categories:

ENZYME