55869 |
HISTONE DEACETYLASE 8 |
HDAC8 |
CDA07 |
CDLS5 |
HD8 |
HDACL1 |
MRXS6 |
RPD3 |
WTS |
300269 |
13315 |
ENSG00000147099 |
OTTHUMG00000021814 |
Q9BY41 |
HDAC8_HUMAN |
BE0001608 |
2619 |
T28887 |
NM_018486 |
NP_060956 |
Target Main Class | Enzymes |
Target Subclass | 3.5.1.98 |
Target Class | Enzymes |
Target Subclass | EC:3.5.1.98 |
Gene Biotype | PROTEIN_CODING |
GuideToPharmacology Gene Category Name | 3.5.1.- Histone deacetylases (HDACs) |
GuideToPharmacology Gene Category ID | 848 |
TRANSCRIPTION FACTOR BINDING |
DRUGGABLE GENOME |
ENZYME |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Notes | |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Trial Name | MGCD-0103 |
Novel drug target | Established target |
Mechanism of Interaction | Histone deacetylase 8 inhibitor |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
Notes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Notes | |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Trial Name | ITF2357,Givinostat |
Novel drug target | Established target |
Notes |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | 4SC-202 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Histone deacetylase inhibitor |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | SB939 |
Novel drug target | Established target |
n/a |
Trial Name | AR-42 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
HDAC8 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
Q9BY41 | Uniprot Accession |
HDAC8 | Gene Symbol |
ENSG00000147099 | Ensembl Gene Id |
Target Main Class | Enzymes |
Target Subclass | 3.5.1.98 |
HDAC8 | Gene Symbol |
Target Subclass | EC:3.5.1.98 |
Target Class | Enzymes |
13315 | HUGO Gene ID |
13315 | HUGO Gene Symbol |
histone deacetylase 8 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | 3.5.1.- Histone deacetylases (HDACs) |
GuideToPharmacology Gene Category ID | 848 |
ENZYME |
HDAC8 | DrugBank Gene Name |
Q9BY41 | UniProt Accession |
55869 | Entrez Gene Id |
ENSG00000147099 | Gene Symbol |
HDAC8 | Ensembl Id |
DRUGGABLE GENOME |
HDACL1 | GENE_SYMBOL |
HDAC8 | GENE_SYMBOL |
Histone deacetylase 8 | UNIPROT |
HDAC8 | Gene Symbol |
Histone deacetylase 8 | Gene Name |
Q9BY41 | UniProt ID |
TRANSCRIPTION FACTOR |
HDACL1 | GO Gene Synonym |
CDA07 | GO Gene Synonym |
TRANSCRIPTION FACTOR BINDING |
HDAC8 | TTD Gene Abbreviation |
T28887 | TTD Target ID |