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HDAC8 Gene Record

  • Summary
  • Interactions
  • Claims
  • HDAC8 55869 Druggable Genome

    Alternate Names:

    55869
    HISTONE DEACETYLASE 8
    HDAC8
    CDA07
    CDLS5
    HD8
    HDACL1
    MRXS6
    RPD3
    WTS
    300269
    13315
    ENSG00000147099
    OTTHUMG00000021814
    Q9BY41
    HDAC8_HUMAN
    BE0001608
    2619
    T28887
    NM_018486
    NP_060956

    Gene Info:

    Target Main Class Enzymes
    Target Subclass 3.5.1.98
    Target Class Enzymes
    Target Subclass EC:3.5.1.98
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)
    GuideToPharmacology Gene Category ID 848
    (8 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
    Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
    Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
    Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
    Daniel KB et al., 2015, Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release., J Med Chem
    Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
    Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
    Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
    Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
    Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
    Klausmeyer P et al., 2011, Histone deacetylase inhibitors from Burkholderia thailandensis., J Nat Prod
    Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
    Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
    Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
    Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
    Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
    Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
    Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
    Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
    Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
    Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
    Gantt SL et al., 2006, Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion., Biochemistry
  • CHEMBL140000   HDAC8

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL12760   HDAC8

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL270672   HDAC8

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • SPIRUCHOSTATIN C   HDAC8

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21967146


    Sources:
    DTC

  • TRICHOSTATIN   HDAC8

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21055848 16921367 19966789 10592235 19385600 17139284 17016423


    Sources:
    DTC DrugBank

  • BELINOSTAT   HDAC8

    Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

  • MOCETINOSTAT   HDAC8

    Interaction Score: 0.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MGCD-0103
    Novel drug target Established target
    Mechanism of Interaction Histone deacetylase 8 inhibitor

    PMIDs:
    23829483 26287310


    Sources:
    DTC TdgClinicalTrial ChemblInteractions

  • VORINOSTAT   HDAC8

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    19344175 19966789 26211462 23622981 25974739 22260166 20491440 21548582 19084294


    Sources:
    TEND DTC DrugBank TALC GuideToPharmacology

  • CUDC-101   HDAC8

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

  • ENTINOSTAT   HDAC8

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes
    Notes

    PMIDs:
    19966789 20491440


    Sources:
    DTC TALC ChemblInteractions

  • APICIDIN   HDAC8

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    19705846


    Sources:
    DTC GuideToPharmacology

  • TACEDINALINE   HDAC8

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    18692397


    Sources:
    DTC ChemblInteractions

  • ROMIDEPSIN   HDAC8

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

  • GIVINOSTAT   HDAC8

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ITF2357,Givinostat
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TALC GuideToPharmacology

  • SCRIPTAID   HDAC8

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    19966789


    Sources:
    DTC GuideToPharmacology

  • VALPROIC ACID   HDAC8

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18294844 16921367 25304896


    Sources:
    DTC

  • CITARINOSTAT   HDAC8

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL324053   HDAC8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367


    Sources:
    DTC

  • CHEMBL117487   HDAC8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17566732


    Sources:
    DTC

  • SUBEROHYDROXAMIC ACID   HDAC8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367


    Sources:
    DTC

  • CHEMBL1650245   HDAC8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • BUTYRYLHYDROXAMIC ACID   HDAC8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • PHENYLBUTYRYLHYDROXAMIC ACID   HDAC8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • RESMINOSTAT   HDAC8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology

  • PANOBINOSTAT   HDAC8

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TALC GuideToPharmacology

  • BUTANOIC ACID   HDAC8

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19053749


    Sources:
    DTC

  • RICOLINOSTAT   HDAC8

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DOMATINOSTAT   HDAC8

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name 4SC-202
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • NANATINOSTAT   HDAC8

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • FERROUS FUMARATE   HDAC8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16681389


    Sources:
    DrugBank

  • FERROUS GLYCINE SULFATE   HDAC8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16681389


    Sources:
    DrugBank

  • PSAMMAPLIN A   HDAC8

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25884112


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC8

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • LARGAZOLE   HDAC8

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • DEPAKOTE   HDAC8

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • AN-9   HDAC8

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • PANOBINOSTAT LACTATE   HDAC8

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DACINOSTAT   HDAC8

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ABEXINOSTAT   HDAC8

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • QUISINOSTAT   HDAC8

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PRACINOSTAT   HDAC8

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name SB939
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AR-42   HDAC8

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AR-42
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   HDAC8

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23622981


    Sources:
    DTC

  • HINOKITIOL   HDAC8

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FIMEPINOSTAT   HDAC8

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAUNORUBICIN   HDAC8

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22260166


    Sources:
    DTC

  • ZINC CHLORIDE   HDAC8

    Interaction Score: 0.02

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    16681389


    Sources:
    DrugBank

  • METHYLDOPA   HDAC8

    Interaction Score: 0.01

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    16681389


    Sources:
    DrugBank

  • Ensembl: ENSG00000147099

    • Version: 101_38

    Alternate Names:
    HDAC8 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q9BY41

    • Version: 01-August-2011

    Alternate Names:
    Q9BY41 Uniprot Accession
    HDAC8 Gene Symbol
    ENSG00000147099 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.5.1.98

    Publications:

  • TdgClinicalTrial: Q9BY41

    • Version: January-2014

    Alternate Names:
    HDAC8 Gene Symbol

    Gene Info:
    Target Subclass EC:3.5.1.98
    Target Class Enzymes

    Publications:

  • GuideToPharmacology: 55869

    • Version: 29-September-2020

    Alternate Names:
    13315 HUGO Gene ID
    13315 HUGO Gene Symbol
    histone deacetylase 8 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)
    GuideToPharmacology Gene Category ID 848

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0001608

    • Version: 5.1.7

    Alternate Names:
    HDAC8 DrugBank Gene Name
    Q9BY41 UniProt Accession
    55869 Entrez Gene Id

    Gene Info:

    Publications:
    Gantt SL et al., 2006, Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion., Biochemistry
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

  • DTC: HDAC8

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
    Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem

  • HingoraniCasas: ENSG00000147099

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000147099 Gene Symbol
    HDAC8 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HDACL1

    • Version: chembl_23

    Alternate Names:
    HDACL1 GENE_SYMBOL
    HDAC8 GENE_SYMBOL
    Histone deacetylase 8 UNIPROT

    Gene Info:

    Publications:

  • TALC: HDAC8

    • Version: 12-May-2016

    Alternate Names:
    HDAC8 Gene Symbol

    Gene Info:

    Publications:

  • Pharos: HDAC8

    • Version: 03-September-2020

    Alternate Names:
    Histone deacetylase 8 Gene Name
    Q9BY41 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • GO: HDAC8

    • Version: 05-September-2020

    Alternate Names:
    HDACL1 GO Gene Synonym
    CDA07 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR BINDING

    Publications:

  • TTD: Histone deacetylase 8

    • Version: 2020.06.01

    Alternate Names:
    HDAC8 TTD Gene Abbreviation
    T28887 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21