DGIdb - HDAC8 Gene Record

HDAC8 55869 Druggable Genome

Alternate Names:

55869
HISTONE DEACETYLASE 8
HDAC8
CDA07
CDLS5
HD8
HDACL1
MRXS6
RPD3
WTS
300269
13315
ENSG00000147099
OTTHUMG00000021814
Q9BY41
HDAC8_HUMAN
T28887
KDAC8

Gene Info:

Target Main Class	Enzymes
Target Subclass	3.5.1.98
Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Daniel KB et al., 2015, Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release., J Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
Klausmeyer P et al., 2011, Histone deacetylase inhibitors from Burkholderia thailandensis., J Nat Prod
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem

SPIRUCHOSTATIN C HDAC8

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21967146

Sources:
DTC
TRICHOSTATIN HDAC8

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367 17139284 17016423 10592235

Sources:
DTC
BELINOSTAT HDAC8

Interaction Score: 0.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name PXD101

Novel drug target Established target

PMIDs:
25937017

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions
MOCETINOSTAT HDAC8

Interaction Score: 0.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 8 inhibitor

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial ChemblInteractions
ENTINOSTAT HDAC8

Interaction Score: 0.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Notes

PMIDs:
20491440 19966789

Sources:
TALC DTC ChemblInteractions
TACEDINALINE HDAC8

Interaction Score: 0.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions
VORINOSTAT HDAC8

Interaction Score: 0.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
23622981 19966789 26211462 25974739 21548582 20491440 19084294 22260166 19344175

Sources:
TALC DTC TEND
NANATINOSTAT HDAC8

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
VALPROIC ACID HDAC8

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
CUDC-101 HDAC8

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
ROMIDEPSIN HDAC8

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions TEND
CHEMBL324053 HDAC8

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
BUTANOIC ACID HDAC8

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
CHEMBL117487 HDAC8

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
APICIDIN HDAC8

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19705846

Sources:
DTC
SUBEROHYDROXAMIC ACID HDAC8

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL1650245 HDAC8

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC8

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
PHENYLBUTYRYLHYDROXAMIC ACID HDAC8

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
DOMATINOSTAT HDAC8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name 4SC-202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
GIVINOSTAT HDAC8

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ITF2357,Givinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
SCRIPTAID HDAC8

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19966789

Sources:
DTC
PSAMMAPLIN A HDAC8

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC8

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
LARGAZOLE HDAC8

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
DEPAKOTE HDAC8

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
PANOBINOSTAT HDAC8

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Panobinostat

Novel drug target Established target

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
AN-9 HDAC8

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
PANOBINOSTAT LACTATE HDAC8

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ABEXINOSTAT HDAC8

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
RESMINOSTAT HDAC8

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Resminostat

PMIDs:
None found

Sources:
TdgClinicalTrial
PRACINOSTAT HDAC8

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SB939

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AR-42 HDAC8

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AR-42

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC8

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC8

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FIMEPINOSTAT HDAC8

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DAUNORUBICIN HDAC8

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000147099
- Version: 101_38
Alternate Names:

HDAC8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q9BY41
- Version: 01-August-2011
Alternate Names:

Q9BY41 Uniprot Accession

HDAC8 Gene Symbol

ENSG00000147099 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 3.5.1.98

Publications:
TdgClinicalTrial: Q9BY41
- Version: January-2014
Alternate Names:

HDAC8 Gene Symbol

Gene Info:

Target Subclass EC:3.5.1.98

Target Class Enzymes

Publications:

DTC: HDAC8

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett

Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol

Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem

HingoraniCasas: ENSG00000147099
- Version: 31-May-2017
Alternate Names:

ENSG00000147099 Gene Symbol

HDAC8 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HDACL1
- Version: chembl_23
Alternate Names:

HDACL1 GENE_SYMBOL

HDAC8 GENE_SYMBOL

Histone deacetylase 8 UNIPROT

Gene Info:

Publications:
TALC: HDAC8
- Version: 12-May-2016
Alternate Names:

HDAC8 Gene Symbol

Gene Info:

Publications:
TTD: Histone deacetylase 8
- Version: 2020.06.01
Alternate Names:

HDAC8 TTD Gene Abbreviation

T28887 TTD Target ID

Gene Info:

Publications:
Pharos: HDAC8
- Version: 01-February-2022
Alternate Names:

Histone deacetylase 8 Gene Name

Q9BY41 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:

Trial Name	MGCD-0103
Novel drug target	Established target
Mechanism of Interaction	Histone deacetylase 8 inhibitor

Mechanism of Interaction	Histone deacetylase inhibitor
Direct Interaction	yes
Notes

Trial Name	ITF2357,Givinostat
Novel drug target	Established target
Notes

Notes
Trial Name	Panobinostat
Novel drug target	Established target

Q9BY41	Uniprot Accession
HDAC8	Gene Symbol
ENSG00000147099	Ensembl Gene Id

HDACL1	GENE_SYMBOL
HDAC8	GENE_SYMBOL
Histone deacetylase 8	UNIPROT

HDAC8 Gene Record

HDAC8 55869 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21967146

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367 17139284 17016423 10592235

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name PXD101 Novel drug target Established target

PMIDs: 25937017

Sources: TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MGCD-0103 Novel drug target Established target Mechanism of Interaction Histone deacetylase 8 inhibitor

PMIDs: 26287310 23829483

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes Notes

PMIDs: 20491440 19966789

Sources: TALC DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 18692397

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: 23622981 19966789 26211462 25974739 21548582 20491440 19084294 22260166 19344175

Sources: TALC DTC TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: None found

Sources: TALC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Notes

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053749

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17566732

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19705846

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24044874

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
21967146

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367 17139284 17016423 10592235

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name PXD101

Novel drug target Established target

PMIDs:
25937017

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 8 inhibitor

PMIDs:
26287310 23829483

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Notes

PMIDs:
20491440 19966789

Sources:
TALC DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
23622981 19966789 26211462 25974739 21548582 20491440 19084294 22260166 19344175

Sources:
TALC DTC TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053749

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17566732

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19705846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name 4SC-202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ITF2357,Givinostat

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19966789

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25884112

Sources:
DTC

Interaction Types & Directionality:

n/a