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HDAC3 Gene Record

  • Summary
  • Interactions
  • Claims
  • HDAC3 8841 Druggable Genome

    Alternate Names:

    8841
    HISTONE DEACETYLASE 3
    HDAC3
    HD3
    RPD3
    RPD3-2
    605166
    4854
    ENSG00000171720
    OTTHUMG00000129629
    SMAP45
    O15379
    HDAC3_HUMAN
    T05090
    KDAC3

    Gene Info:

    Target Main Class Enzymes
    Target Subclass 3.5.1.98
    Target Class Enzymes
    Target Subclass EC:3.5.1.98
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
    Pérez-Balado C et al., 2007, Bispyridinium dienes: histone deacetylase inhibitors with selective activities., J Med Chem
    Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
    Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
    Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
    Li X et al., 2014, Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity., J Med Chem
    Olson DE et al., 2013, Discovery of the first histone deacetylase 6/8 dual inhibitors., J Med Chem
    Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
    Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
    Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
    Xu et al., 2007, Histone deacetylase inhibitors: molecular mechanisms of action., Oncogene
    Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
    Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
    Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
    Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
    Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
    Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
    Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
    Beckers et al., 2007, Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group., Int. J. Cancer
    Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
    Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
    Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
    Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
    Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
    Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
    Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
    Lahm A et al., 2007, Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases., Proc Natl Acad Sci U S A
    Chen IH et al., 2009, Cytotoxic triterpenoids from the stems of Microtropis japonica., J Nat Prod
    Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
    Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
  • NANATINOSTAT   HDAC3

    Interaction Score: 0.81

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC TTD

  • MOCETINOSTAT   HDAC3

    Interaction Score: 0.75

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase 3
    Trial Name MGCD-0103

    PMIDs:
    26287310 23829483 17455259


    Sources:
    DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC3

    Interaction Score: 0.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes
    Trial Name PXD101

    PMIDs:
    25937017


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • VORINOSTAT   HDAC3

    Interaction Score: 0.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase 3 inhibitor
    Notes

    PMIDs:
    17447750 23622981 19966789 26211462 24694055 23672185 21548582 20491440 19084294 22260166 19344175 17694093


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions TEND

  • ENTINOSTAT   HDAC3

    Interaction Score: 0.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor
    Trial Name entinostat, SNDX-275, MS-275

    PMIDs:
    20491440 19966789


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • APICIDIN   HDAC3

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19705846 17956988


    Sources:
    DTC

  • TACEDINALINE   HDAC3

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    18692397


    Sources:
    DTC ChemblInteractions

  • TRICHOSTATIN   HDAC3

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19966789 19385600 21055848 16921367


    Sources:
    DTC

  • CHIDAMIDE   HDAC3

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Chidamide, HBI-8000
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PANOBINOSTAT   HDAC3

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Panobinostat
    Novel drug target Established target
    Notes

    PMIDs:
    24694055


    Sources:
    TALC DTC TdgClinicalTrial

  • VALPROIC ACID   HDAC3

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367 25304896 18294844


    Sources:
    DTC

  • CUDC-101   HDAC3

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Novel drug target Established target
    Trial Name CUDC-101

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions

  • ROMIDEPSIN   HDAC3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Depsipeptide
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial ChemblInteractions TEND

  • CHEMBL1650245   HDAC3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • PHENYLBUTYRYLHYDROXAMIC ACID   HDAC3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • ABEXINOSTAT   HDAC3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name PCI-27483, CRA-024781
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial

  • SUBEROHYDROXAMIC ACID   HDAC3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367


    Sources:
    DTC

  • BUTYRYLHYDROXAMIC ACID   HDAC3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21874153


    Sources:
    DTC

  • CHEMBL324053   HDAC3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921367


    Sources:
    DTC

  • BUTANOIC ACID   HDAC3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19053749


    Sources:
    DTC

  • CHEMBL117487   HDAC3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17566732


    Sources:
    DTC

  • URSOLIC ACID   HDAC3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19534471


    Sources:
    DTC

  • DOMATINOSTAT   HDAC3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name 4SC-202
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • GIVINOSTAT   HDAC3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ITF2357,Givinostat
    Notes

    PMIDs:
    None found


    Sources:
    TALC TdgClinicalTrial

  • SCRIPTAID   HDAC3

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19966789


    Sources:
    DTC

  • PSAMMAPLIN A   HDAC3

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25884112


    Sources:
    DTC

  • PHENYLBUTANOIC ACID   HDAC3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044874


    Sources:
    DTC

  • LARGAZOLE   HDAC3

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21420302 25203782 20491440


    Sources:
    DTC

  • DEPAKOTE   HDAC3

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • AN-9   HDAC3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • PANOBINOSTAT LACTATE   HDAC3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RESMINOSTAT   HDAC3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Resminostat
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PRACINOSTAT   HDAC3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name SB939
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AR-42   HDAC3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AR-42
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   HDAC3

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23622981


    Sources:
    DTC

  • HINOKITIOL   HDAC3

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FIMEPINOSTAT   HDAC3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAUNORUBICIN   HDAC3

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22260166


    Sources:
    DTC

  • Ensembl: ENSG00000171720

    • Version: 101_38

    Alternate Names:
    HDAC3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: O15379

    • Version: 01-August-2011

    Alternate Names:
    8841 Entrez Gene Id
    O15379 Uniprot Accession
    ENSG00000171720 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.5.1.98

    Publications:

  • TdgClinicalTrial: O15379

    • Version: January-2014

    Alternate Names:
    HDAC3 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.5.1.98

    Publications:

  • DTC: HDAC3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
    Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem

  • HingoraniCasas: ENSG00000171720

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000171720 Gene Symbol
    HDAC3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: HDAC3

    • Version: 12-May-2016

    Alternate Names:
    HDAC3 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: HDAC3

    • Version: chembl_23

    Alternate Names:
    HDAC3 GENE_SYMBOL
    Histone deacetylase 3 UNIPROT
    RPD3-2 UNIPROT

    Gene Info:

    Publications:

  • TTD: Histone deacetylase 3

    • Version: 2020.06.01

    Alternate Names:
    HDAC3 TTD Gene Abbreviation
    T05090 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: HDAC3

    • Version: 01-February-2022

    Alternate Names:
    Histone deacetylase 3 Gene Name
    O15379 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21