DGIdb - HDAC2 Gene Record

HDAC2 3066 Druggable Genome

Alternate Names:

3066
HISTONE DEACETYLASE 2
HDAC2
HD2
RPD3
YAF1
605164
4853
ENSG00000196591
OTTHUMG00000015411
Q92769
HDAC2_HUMAN
T51191
2578
KDAC2

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Target Main Class	Enzymes
Target Subclass	3.5.1.98
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
Li X et al., 2014, Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity., J Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Olson DE et al., 2013, Discovery of the first histone deacetylase 6/8 dual inhibitors., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
Pérez-Balado C et al., 2007, Bispyridinium dienes: histone deacetylase inhibitors with selective activities., J Med Chem
Xu et al., 2007, Histone deacetylase inhibitors: molecular mechanisms of action., Oncogene
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
Khan et al., 2008, Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors., Biochem. J.
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
VanderMolen et al., 2011, Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma., J. Antibiot.
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Aggarwal R et al., 2017, Inhibiting Histone Deacetylase as a Means to Reverse Resistance to Angiogenesis Inhibitors: Phase I Study of Abexinostat Plus Pazopanib in Advanced Solid Tumor Malignancies., J Clin Oncol
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Hirata Y et al., 2012, Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain., Bioorg Med Chem Lett
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem

CINNAMIC ACID HYDROXAMATE HDAC2

Interaction Score: 3.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
NANATINOSTAT HDAC2

Interaction Score: 0.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC TTD
MOCETINOSTAT HDAC2

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 2 inhibitor

PMIDs:
17868033 26287310 23829483

Sources:
DTC TdgClinicalTrial ChemblInteractions
VORINOSTAT HDAC2

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase 2 inhibitor

Direct Interaction yes

PMIDs:
23622981 19966789 26211462 21548582 20491440 23672185 19084294 22260166 19344175 24074025 17447750 24694055 17694093

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions TEND
BELINOSTAT HDAC2

Interaction Score: 0.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
25937017

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions
ABEXINOSTAT HDAC2

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

Notes

PMIDs:
28221861

Sources:
TALC TdgClinicalTrial CIViC
ENTINOSTAT HDAC2

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
20491440 19966789 22321215

Sources:
TALC DTC ChemblInteractions
TRICHOSTATIN HDAC2

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789 19385600 21055848 16921367 24074025

Sources:
DTC
TACEDINALINE HDAC2

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions
ROMIDEPSIN HDAC2

Interaction Score: 0.42

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
21587264

Sources:
TALC TdgClinicalTrial ChemblInteractions TEND
CHIDAMIDE HDAC2

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Chidamide, HBI-8000

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
PANOBINOSTAT HDAC2

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Panobinostat

Notes

PMIDs:
24694055

Sources:
TALC DTC TdgClinicalTrial
VALPROIC ACID HDAC2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367 25304896 18294844

Sources:
DTC
CUDC-101 HDAC2

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Trial Name CUDC-101

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions
SUBEROHYDROXAMIC ACID HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL1650245 HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
PHENYLBUTYRYLHYDROXAMIC ACID HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
APICIDIN HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19705846

Sources:
DTC
BUTANOIC ACID HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
CHEMBL324053 HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL117487 HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
DOMATINOSTAT HDAC2

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name 4SC-202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SCRIPTAID HDAC2

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19966789

Sources:
DTC
GIVINOSTAT HDAC2

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ITF2357,Givinostat

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
PSAMMAPLIN A HDAC2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
LARGAZOLE HDAC2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
DEPAKOTE HDAC2

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
AN-9 HDAC2

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
PANOBINOSTAT LACTATE HDAC2

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RESMINOSTAT HDAC2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resminostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AR-42 HDAC2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name AR-42

PMIDs:
None found

Sources:
TdgClinicalTrial
PRACINOSTAT HDAC2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SB939

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FIMEPINOSTAT HDAC2

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PAZOPANIB HDAC2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28221861

Sources:
CIViC
DAUNORUBICIN HDAC2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000196591
- Version: 101_38
Alternate Names:

HDAC2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q92769
- Version: January-2014
Alternate Names:

HDAC2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:
TEND: Q92769
- Version: 01-August-2011
Alternate Names:

HDAC2 Gene Symbol

HDAC2_HUMAN Uniprot Id

ENSG00000196591 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 3.5.1.98

Publications:

CIViC: HDAC2

Version: 14-September-2020

Alternate Names:

3066 Entrez Gene ID

2578 CIViC Gene ID

Gene Info:

Publications:

Aggarwal R et al., 2017, Inhibiting Histone Deacetylase as a Means to Reverse Resistance to Angiogenesis Inhibitors: Phase I Study of Abexinostat Plus Pazopanib in Advanced Solid Tumor Malignancies., J Clin Oncol

DTC: HDAC2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett

Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett

Li X et al., 2014, Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity., J Med Chem

HingoraniCasas: ENSG00000196591
- Version: 31-May-2017
Alternate Names:

ENSG00000196591 Gene Symbol

HDAC2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HDAC2
- Version: chembl_23
Alternate Names:

HDAC2 GENE_SYMBOL

Histone deacetylase 2 UNIPROT

HD2 UNIPROT

Gene Info:

Publications:
TALC: HDAC2
- Version: 12-May-2016
Alternate Names:

HDAC2 Gene Symbol

Gene Info:

Publications:
Tempus: HDAC2
- Version: 11-November-2018
Alternate Names:

HDAC2 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Histone deacetylase 2
- Version: 2020.06.01
Alternate Names:

HDAC2 TTD Gene Abbreviation

T51191 TTD Target ID

Gene Info:

Publications:
Pharos: HDAC2
- Version: 01-February-2022
Alternate Names:

Histone deacetylase 2 Gene Name

Q92769 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:

Trial Name	MGCD-0103
Novel drug target	Established target
Mechanism of Interaction	Histone deacetylase 2 inhibitor

Notes
Mechanism of Interaction	Histone deacetylase 2 inhibitor
Direct Interaction	yes

Trial Name	PCI-27483, CRA-024781
Novel drug target	Established target
Notes

Notes
Mechanism of Interaction	Histone deacetylase inhibitor
Direct Interaction	yes

Trial Name	Chidamide, HBI-8000
Novel drug target	Established target

HDAC2	Gene Symbol
HDAC2_HUMAN	Uniprot Id
ENSG00000196591	Ensembl Gene Id

antagonist (inhibitory)
inhibitor (inhibitory)

HDAC2 Gene Record

HDAC2 3066 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: None found

Sources: TALC TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MGCD-0103 Novel drug target Established target Mechanism of Interaction Histone deacetylase 2 inhibitor

PMIDs: 17868033 26287310 23829483

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Histone deacetylase 2 inhibitor Direct Interaction yes

PMIDs: 23622981 19966789 26211462 21548582 20491440 23672185 19084294 22260166 19344175 24074025 17447750 24694055 17694093

Sources: TALC DTC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction yes Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: 25937017

Sources: TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name PCI-27483, CRA-024781 Novel drug target Established target Notes

PMIDs: 28221861

Sources: TALC TdgClinicalTrial CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 20491440 19966789 22321215

Sources: TALC DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789 19385600 21055848 16921367 24074025

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 18692397

Sources: DTC ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 21587264

Sources: TALC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Chidamide, HBI-8000 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Panobinostat Notes

PMIDs: 24694055

Sources: TALC DTC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367 25304896 18294844

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes Trial Name CUDC-101

PMIDs: None found

Sources: TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24044874

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 2 inhibitor

PMIDs:
17868033 26287310 23829483

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase 2 inhibitor

Direct Interaction yes

PMIDs:
23622981 19966789 26211462 21548582 20491440 23672185 19084294 22260166 19344175 24074025 17447750 24694055 17694093

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
25937017

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

Notes

PMIDs:
28221861

Sources:
TALC TdgClinicalTrial CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
20491440 19966789 22321215

Sources:
TALC DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19966789 19385600 21055848 16921367 24074025

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
18692397

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
21587264

Sources:
TALC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Chidamide, HBI-8000

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Panobinostat

Notes

PMIDs:
24694055

Sources:
TALC DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
16921367 25304896 18294844

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Trial Name CUDC-101

PMIDs:
None found

Sources:
TALC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19705846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053749

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17566732

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name 4SC-202

Novel drug target Established target

PMIDs:
None found