3066 |
HISTONE DEACETYLASE 2 |
HDAC2 |
HD2 |
RPD3 |
YAF1 |
605164 |
4853 |
ENSG00000196591 |
OTTHUMG00000015411 |
Q92769 |
BE0002366 |
2616 |
HDAC2_HUMAN |
T51191 |
2578 |
NM_001527 |
NP_001518 |
Target Class | Enzymes |
Target Subclass | EC:3.5.1.98 |
Target Main Class | Enzymes |
Target Subclass | 3.5.1.98 |
Gene Biotype | PROTEIN_CODING |
GuideToPharmacology Gene Category Name | 3.5.1.- Histone deacetylases (HDACs) |
GuideToPharmacology Gene Category ID | 848 |
DRUG RESISTANCE |
TRANSCRIPTION FACTOR BINDING |
DRUGGABLE GENOME |
ENZYME |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Trial Name | MGCD-0103 |
Novel drug target | Established target |
Mechanism of Interaction | Histone deacetylase 2 inhibitor |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Notes | |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Notes | |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | PCI-27483, CRA-024781 |
Novel drug target | Established target |
Notes |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
Direct Interaction? | False |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Notes | |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | Panobinostat |
Notes |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | Chidamide, HBI-8000 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | ITF2357,Givinostat |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | 4SC-202 |
Novel drug target | Established target |
n/a |
Trial Name | SB939 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | Resminostat |
Novel drug target | Established target |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Novel drug target | Established target |
Trial Name | AR-42 |
n/a |
Drug family | PARP inhibitor |
Alteration | HDAC2:. |
HDAC2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
HDAC2 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:3.5.1.98 |
HDAC2 | Gene Symbol |
HDAC2_HUMAN | Uniprot Id |
ENSG00000196591 | Ensembl Gene Id |
Target Main Class | Enzymes |
Target Subclass | 3.5.1.98 |
4853 | HUGO Gene ID |
4853 | HUGO Gene Symbol |
histone deacetylase 2 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | 3.5.1.- Histone deacetylases (HDACs) |
GuideToPharmacology Gene Category ID | 848 |
ENZYME |
3066 | Entrez Gene ID |
2578 | CIViC Gene ID |
HDAC2 | DrugBank Gene Name |
Q92769 | UniProt Accession |
3066 | Entrez Gene Id |
ENSG00000196591 | Gene Symbol |
HDAC2 | Ensembl Id |
DRUGGABLE GENOME |
HDAC2 | GENE_SYMBOL |
Histone deacetylase 2 | UNIPROT |
HD2 | UNIPROT |
HDAC2 | Gene Symbol |
Histone deacetylase 2 | Gene Name |
Q92769 | UniProt ID |
TRANSCRIPTION FACTOR |
HDAC2 | Gene Symbol |
CLINICALLY ACTIONABLE |
HDAC2 | TTD Gene Abbreviation |
T51191 | TTD Target ID |
DRUG RESISTANCE, TRANSCRIPTION FACTOR BINDING |