DGIdb - HDAC2 Gene Record

HDAC2 3066 Druggable GenomeDrug Resistance

Alternate Names:

3066
HISTONE DEACETYLASE 2
HDAC2
HD2
RPD3
YAF1
605164
4853
ENSG00000196591
OTTHUMG00000015411
Q92769
BE0002366
2616
HDAC2_HUMAN
T51191
2578
NM_001527
NP_001518

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Target Main Class	Enzymes
Target Subclass	3.5.1.98
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	3.5.1.- Histone deacetylases (HDACs)
GuideToPharmacology Gene Category ID	848

(11 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
Ito et al., 2002, A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression., Proc. Natl. Acad. Sci. U.S.A.
Cosio et al., 2004, Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages., J. Exp. Med.
Li X et al., 2014, Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity., J Med Chem
Xu et al., 2007, Histone deacetylase inhibitors: molecular mechanisms of action., Oncogene
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Pérez-Balado C et al., 2007, Bispyridinium dienes: histone deacetylase inhibitors with selective activities., J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
Olson DE et al., 2013, Discovery of the first histone deacetylase 6/8 dual inhibitors., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Khan et al., 2008, Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors., Biochem. J.
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
VanderMolen et al., 2011, Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma., J. Antibiot.
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Aggarwal R et al., 2017, Inhibiting Histone Deacetylase as a Means to Reverse Resistance to Angiogenesis Inhibitors: Phase I Study of Abexinostat Plus Pazopanib in Advanced Solid Tumor Malignancies., J Clin Oncol
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Hirata Y et al., 2012, Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain., Bioorg Med Chem Lett
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem
Lin et al., 2008, Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2., Cancer Res.
Barnes PJ, 2006, How corticosteroids control inflammation: Quintiles Prize Lecture 2005., Br J Pharmacol

CINNAMIC ACID HYDROXAMATE HDAC2

Interaction Score: 2.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
TIXOCORTOL HDAC2

Interaction Score: 1.07

Interaction Types & Directionality:

stimulator (activating)

Interaction Info:

PMIDs:
16604091

Sources:
DrugBank
MOCETINOSTAT HDAC2

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 2 inhibitor

PMIDs:
23829483 17868033 26287310

Sources:
DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
NANATINOSTAT HDAC2

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD TALC GuideToPharmacology
BELINOSTAT HDAC2

Interaction Score: 0.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
25937017

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions
VORINOSTAT HDAC2

Interaction Score: 0.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
24694055 17694093 19344175 19966789 26211462 23622981 22260166 17447750 20491440 21548582 24074025 23672185 19084294

Sources:
TEND DTC TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions
ENTINOSTAT HDAC2

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
19966789 20491440 22321215

Sources:
DTC TALC GuideToPharmacology ChemblInteractions
ABEXINOSTAT HDAC2

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

Notes

PMIDs:
28221861

Sources:
TdgClinicalTrial CIViC TALC
TACEDINALINE HDAC2

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Direct Interaction? False

PMIDs:
18692397

Sources:
DTC GuideToPharmacology ChemblInteractions
ROMIDEPSIN HDAC2

Interaction Score: 0.38

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
21587264

Sources:
TEND TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions
TRICHOSTATIN HDAC2

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600 24074025

Sources:
DTC
PANOBINOSTAT HDAC2

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Panobinostat

Notes

PMIDs:
24694055

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology
CUDC-101 HDAC2

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions
APICIDIN HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19705846

Sources:
DTC GuideToPharmacology
OXTRIPHYLLINE HDAC2

Interaction Score: 0.29

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
12070353 15337792

Sources:
DrugBank
CHIDAMIDE HDAC2

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Chidamide, HBI-8000

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SCRIPTAID HDAC2

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
19966789

Sources:
DTC GuideToPharmacology
GIVINOSTAT HDAC2

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ITF2357,Givinostat

Direct Interaction? False

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology
VALPROIC ACID HDAC2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18294844 16921367 25304896

Sources:
DTC
CITARINOSTAT HDAC2

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
SUBEROHYDROXAMIC ACID HDAC2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL1650245 HDAC2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
AMINOPHYLLINE HDAC2

Interaction Score: 0.19

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
12070353

Sources:
DrugBank
PHENYLBUTYRYLHYDROXAMIC ACID HDAC2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
CHEMBL324053 HDAC2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL117487 HDAC2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
DOMATINOSTAT HDAC2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name 4SC-202

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BUTANOIC ACID HDAC2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
PRACINOSTAT HDAC2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SB939

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial DrugBank
RICOLINOSTAT HDAC2

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
PSAMMAPLIN A HDAC2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
LARGAZOLE HDAC2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
DEPAKOTE HDAC2

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
AN-9 HDAC2

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
FIMEPINOSTAT HDAC2

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
PANOBINOSTAT LACTATE HDAC2

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THEOPHYLLINE HDAC2

Interaction Score: 0.1

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
12070353 15337792

Sources:
DrugBank
FLUVASTATIN HDAC2

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18381445

Sources:
DrugBank
DACINOSTAT HDAC2

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
RESMINOSTAT HDAC2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resminostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
QUISINOSTAT HDAC2

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
AR-42 HDAC2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name AR-42

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRAVASTATIN HDAC2

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18381445

Sources:
DrugBank
PAZOPANIB HDAC2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28221861

Sources:
CIViC
LOVASTATIN HDAC2

Interaction Score: 0.05

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
18381445

Sources:
DrugBank
SIMVASTATIN HDAC2

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18381445

Sources:
DrugBank
OLAPARIB HDAC2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family PARP inhibitor

Alteration HDAC2:.

PMIDs:
None found

Sources:
CGI
ATORVASTATIN HDAC2

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
18381445

Sources:
DrugBank
DAUNORUBICIN HDAC2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000196591
- Version: 101_38
Alternate Names:

HDAC2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q92769
- Version: January-2014
Alternate Names:

HDAC2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:
TEND: Q92769
- Version: 01-August-2011
Alternate Names:

HDAC2 Gene Symbol

HDAC2_HUMAN Uniprot Id

ENSG00000196591 Ensembl Gene Id

Gene Info:

Target Main Class Enzymes

Target Subclass 3.5.1.98

Publications:
GuideToPharmacology: 3066
- Version: 29-September-2020
Alternate Names:

4853 HUGO Gene ID

4853 HUGO Gene Symbol

histone deacetylase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)

GuideToPharmacology Gene Category ID 848

Gene Categories:

ENZYME

Publications:

CIViC: HDAC2

Version: 14-September-2020

Alternate Names:

3066 Entrez Gene ID

2578 CIViC Gene ID

Gene Info:

Publications:

Aggarwal R et al., 2017, Inhibiting Histone Deacetylase as a Means to Reverse Resistance to Angiogenesis Inhibitors: Phase I Study of Abexinostat Plus Pazopanib in Advanced Solid Tumor Malignancies., J Clin Oncol

DrugBank: BE0002366

Version: 5.1.7

Alternate Names:

HDAC2 DrugBank Gene Name

Q92769 UniProt Accession

3066 Entrez Gene Id

Gene Info:

Publications:

Lin et al., 2008, Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2., Cancer Res.

Ito et al., 2002, A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression., Proc. Natl. Acad. Sci. U.S.A.

Cosio et al., 2004, Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages., J. Exp. Med.

DTC: HDAC2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett

Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett

Li X et al., 2014, Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity., J Med Chem

HingoraniCasas: ENSG00000196591
- Version: 31-May-2017
Alternate Names:

ENSG00000196591 Gene Symbol

HDAC2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HDAC2
- Version: chembl_23
Alternate Names:

HDAC2 GENE_SYMBOL

Histone deacetylase 2 UNIPROT

HD2 UNIPROT

Gene Info:

Publications:
TALC: HDAC2
- Version: 12-May-2016
Alternate Names:

HDAC2 Gene Symbol

Gene Info:

Publications:
Pharos: HDAC2
- Version: 03-September-2020
Alternate Names:

Histone deacetylase 2 Gene Name

Q92769 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
Tempus: HDAC2
- Version: 11-November-2018
Alternate Names:

HDAC2 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Histone deacetylase 2
- Version: 2020.06.01
Alternate Names:

HDAC2 TTD Gene Abbreviation

T51191 TTD Target ID

Gene Info:

Publications:
CGI: HDAC2
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:
GO: HDAC2
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE, TRANSCRIPTION FACTOR BINDING

Publications:

Trial Name	MGCD-0103
Novel drug target	Established target
Mechanism of Interaction	Histone deacetylase 2 inhibitor

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Notes
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Notes
Mechanism of Interaction	Histone deacetylase inhibitor
Direct Interaction	yes

Trial Name	PCI-27483, CRA-024781
Novel drug target	Established target
Notes

Trial Name	Chidamide, HBI-8000
Novel drug target	Established target

HDAC2	Gene Symbol
HDAC2_HUMAN	Uniprot Id
ENSG00000196591	Ensembl Gene Id

4853	HUGO Gene ID
4853	HUGO Gene Symbol
histone deacetylase 2	HUGO Gene Name

HDAC2	DrugBank Gene Name
Q92769	UniProt Accession
3066	Entrez Gene Id

antagonist (inhibitory)
inhibitor (inhibitory)

HDAC2 Gene Record

HDAC2 3066 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: stimulator (activating)

Interaction Info:

PMIDs: 16604091

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MGCD-0103 Novel drug target Established target Mechanism of Interaction Histone deacetylase 2 inhibitor

PMIDs: 23829483 17868033 26287310

Sources: DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TTD TALC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 25937017

Sources: DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 24694055 17694093 19344175 19966789 26211462 23622981 22260166 17447750 20491440 21548582 24074025 23672185 19084294

Sources: TEND DTC TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes

PMIDs: 19966789 20491440 22321215

Sources: DTC TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name PCI-27483, CRA-024781 Novel drug target Established target Notes

PMIDs: 28221861

Sources: TdgClinicalTrial CIViC TALC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes Direct Interaction? False

PMIDs: 18692397

Sources: DTC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Notes Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 21587264

Sources: TEND TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600 24074025

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Panobinostat Notes

PMIDs: 24694055

Sources: DTC TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Histone deacetylase inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 19705846

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 12070353 15337792

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Chidamide, HBI-8000 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 19966789

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ITF2357,Givinostat Direct Interaction? False

PMIDs: None found

Sources: TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

stimulator (activating)

PMIDs:
16604091

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 2 inhibitor

PMIDs:
23829483 17868033 26287310

Sources:
DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD TALC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
25937017

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
24694055 17694093 19344175 19966789 26211462 23622981 22260166 17447750 20491440 21548582 24074025 23672185 19084294

Sources:
TEND DTC TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
19966789 20491440 22321215

Sources:
DTC TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name PCI-27483, CRA-024781

Novel drug target Established target

Notes

PMIDs:
28221861

Sources:
TdgClinicalTrial CIViC TALC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Direct Interaction? False

PMIDs:
18692397

Sources:
DTC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
21587264

Sources:
TEND TdgClinicalTrial DrugBank TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600 24074025

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Panobinostat

Notes

PMIDs:
24694055

Sources:
DTC TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19705846

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

activator (activating)

PMIDs:
12070353 15337792

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Chidamide, HBI-8000

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
19966789

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ITF2357,Givinostat

Direct Interaction? False

PMIDs:
None found

Sources:
TdgClinicalTrial TALC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18294844 16921367 25304896

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874