DGIdb - HDAC11 Gene Record

HDAC11 79885 Druggable Genome

Alternate Names:

79885
HISTONE DEACETYLASE 11
HDAC11
HD11
607226
19086
ENSG00000163517
OTTHUMG00000129800
Q96DB2
2615
PA38793
T97903
NP_079103
NM_024827

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.98
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	3.5.1.- Histone deacetylases (HDACs)
GuideToPharmacology Gene Category ID	848

(7 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
ENZYME

Publications:

Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem
Grolla AA et al., 2009, Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases., J Med Chem
Hutt DM et al., 2010, Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis., Nat Chem Biol
Yang W et al., 2015, Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors., Bioorg Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Neelarapu R et al., 2011, Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes., J Med Chem
Dallavalle S et al., 2009, Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors., Eur J Med Chem
Marson CM et al., 2013, Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit., J Med Chem
Marson CM et al., 2015, Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit., J Med Chem
Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
Mimori S et al., 2013, 4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor., Bioorg Med Chem Lett
Shi Y et al., 2007, Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition., Bioorg Med Chem Lett
Thomas M et al., 2008, Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy., Bioorg Med Chem
Marrazzo A et al., 2011, Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells., Eur J Med Chem
Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol
Charrier C et al., 2009, Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression., J Med Chem
Campbell CT et al., 2008, Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells., J Med Chem
Hong S et al., 2015, Efficient synthesis and biological activity of Psammaplin A and its analogues as antitumor agents., Eur J Med Chem
Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett
Perrino E et al., 2008, New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity., Bioorg Med Chem Lett
Petrelli R et al., 2014, From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine., Bioorg Med Chem Lett
Benelkebir H et al., 2011, Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability., Bioorg Med Chem
Bhansali P et al., 2014, Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groups., Eur J Med Chem

MOCETINOSTAT HDAC11

Interaction Score: 0.7

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 11

PMIDs:
23829483 26287310

Sources:
DTC TdgClinicalTrial ChemblInteractions
BELINOSTAT HDAC11

Interaction Score: 0.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

Trial Name PXD101

PMIDs:
25937017

Sources:
DTC TdgClinicalTrial ChemblInteractions
TACEDINALINE HDAC11

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
18692397

Sources:
DTC ChemblInteractions
TRICHOSTATIN HDAC11

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC
VORINOSTAT HDAC11

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19344175 19966789 26211462 23622981 22260166 20491440 21548582 19084294

Sources:
ClearityFoundationClinicalTrial DTC TALC GuideToPharmacology
VALPROIC ACID HDAC11

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18294844 16921367 25304896

Sources:
DTC
ENTINOSTAT HDAC11

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
19966789 20491440

Sources:
DTC ChemblInteractions
CHEMBL1650245 HDAC11

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
PHENYLBUTYRYLHYDROXAMIC ACID HDAC11

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
BUTYRYLHYDROXAMIC ACID HDAC11

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21874153

Sources:
DTC
CHEMBL324053 HDAC11

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
SUBEROHYDROXAMIC ACID HDAC11

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921367

Sources:
DTC
CHEMBL117487 HDAC11

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17566732

Sources:
DTC
APICIDIN HDAC11

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19705846

Sources:
DTC
SCRIPTAID HDAC11

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19966789

Sources:
DTC
BUTANOIC ACID HDAC11

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053749

Sources:
DTC
PSAMMAPLIN A HDAC11

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884112

Sources:
DTC
PHENYLBUTANOIC ACID HDAC11

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24044874

Sources:
DTC
CUDC-101 HDAC11

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
LARGAZOLE HDAC11

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21420302 25203782 20491440

Sources:
DTC
PANOBINOSTAT HDAC11

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Panobinostat

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC
FIMEPINOSTAT HDAC11

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
ROMIDEPSIN HDAC11

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Depsipeptide

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
PANOBINOSTAT LACTATE HDAC11

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RESMINOSTAT HDAC11

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Resminostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
QUISINOSTAT HDAC11

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PRACINOSTAT HDAC11

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name SB939

PMIDs:
None found

Sources:
TdgClinicalTrial
AR-42 HDAC11

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AR-42

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC11

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
HINOKITIOL HDAC11

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HDAC11

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22260166

Sources:
DTC

Ensembl: ENSG00000163517
- Version: 101_38
Alternate Names:

HDAC11 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q96DB2
- Version: January-2014
Alternate Names:

HDAC11 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.98

Publications:
GuideToPharmacology: 79885
- Version: 29-September-2020
Alternate Names:

19086 HUGO Gene ID

19086 HUGO Gene Symbol

histone deacetylase 11 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)

GuideToPharmacology Gene Category ID 848

Gene Categories:

ENZYME

Publications:
PharmGKB: HDAC11
- Version: 18-August-2020
Alternate Names:

PA38793 PharmGKB ID

Gene Info:

Publications:

Ghodke-Puranik Y et al., 2013, Valproic acid pathway: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DTC: HDAC11

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Olsen CA et al., 2009, Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides., J Med Chem

Fass et al., 2010, Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin., ACS Med Chem Lett

Herman D et al., 2006, Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia., Nat Chem Biol

TALC: HDAC11
- Version: 12-May-2016
Alternate Names:

HDAC11 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: HDAC11
- Version: chembl_23
Alternate Names:

HDAC11 GENE_SYMBOL

Histone deacetylase 11 UNIPROT

HD11 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000163517
- Version: 31-May-2017
Alternate Names:

ENSG00000163517 Gene Symbol

HDAC11 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Histone deacetylase 11
- Version: 2020.06.01
Alternate Names:

HDAC11 TTD Gene Abbreviation

T97903 TTD Target ID

Gene Info:

Publications:
ClearityFoundationClinicalTrial: HDAC11
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
GO: HDAC11
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR BINDING

Publications:

Trial Name	MGCD-0103
Novel drug target	Established target
Mechanism of Interaction	Histone deacetylase 11

Direct Interaction	yes
Mechanism of Interaction	Histone deacetylase inhibitor
Trial Name	PXD101

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	CUDC-101
Novel drug target	Established target
Mechanism of Interaction	Histone deacetylase inhibitor

Trial Name	Depsipeptide
Novel drug target	Established target
Mechanism of Interaction	Histone deacetylase inhibitor

19086	HUGO Gene ID
19086	HUGO Gene Symbol
histone deacetylase 11	HUGO Gene Name

HDAC11 Gene Record

HDAC11 79885 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MGCD-0103 Novel drug target Established target Mechanism of Interaction Histone deacetylase 11

PMIDs: 23829483 26287310

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Histone deacetylase inhibitor Trial Name PXD101

PMIDs: 25937017

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: 18692397

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21055848 16921367 19966789 19385600

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 19344175 19966789 26211462 23622981 22260166 20491440 21548582 19084294

Sources: ClearityFoundationClinicalTrial DTC TALC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18294844 16921367 25304896

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Histone deacetylase inhibitor

PMIDs: 19966789 20491440

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24044874

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21874153

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921367

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17566732

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19705846

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19966789

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053749

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25884112

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24044874

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CUDC-101 Novel drug target Established target Mechanism of Interaction Histone deacetylase inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MGCD-0103

Novel drug target Established target

Mechanism of Interaction Histone deacetylase 11

PMIDs:
23829483 26287310

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

Trial Name PXD101

PMIDs:
25937017

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
18692397

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21055848 16921367 19966789 19385600

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19344175 19966789 26211462 23622981 22260166 20491440 21548582 19084294

Sources:
ClearityFoundationClinicalTrial DTC TALC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18294844 16921367 25304896

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
19966789 20491440

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21874153

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16921367

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17566732

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19705846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19966789

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053749

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25884112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24044874

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CUDC-101

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21420302 25203782 20491440

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Panobinostat

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TALC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Depsipeptide

Novel drug target Established target

Mechanism of Interaction Histone deacetylase inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Histone deacetylase inhibitor

Direct Interaction yes