3065 |
HISTONE DEACETYLASE 1 |
HDAC1 |
GON-10 |
HD1 |
RPD3 |
RPD3L1 |
601241 |
4852 |
ENSG00000116478 |
OTTHUMG00000007529 |
Q13547 |
HDAC |
HDAC1_HUMAN |
BE0008667 |
BE0002365 |
2658 |
PA29226 |
T68547 |
NP_004955 |
NM_004964 |
Target Class | Enzymes |
Target Subclass | EC:3.5.1.98 |
Target Main Class | Enzymes |
Target Subclass | 3.5.1.98 |
CancerCommons Reported Gene Name | HDAC |
Gene Biotype | PROTEIN_CODING |
GuideToPharmacology Gene Category Name | 3.5.1.- Histone deacetylases (HDACs) |
GuideToPharmacology Gene Category ID | 848 |
TRANSCRIPTION FACTOR BINDING |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
ENZYME |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Trial Name | PXD101 |
Novel drug target | Established target |
Notes |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | entinostat, SNDX-275, MS-275 |
Notes |
inhibitor (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Notes | |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Direct Interaction? | True |
Direct Interaction? | False |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Notes | |
Trial Name | ITF2357,Givinostat |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | 4SC-202 |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | CUDC-101 |
Mechanism of Interaction | Histone deacetylase inhibitor |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | Chidamide, HBI-8000 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Mechanism of Interaction | Histone deacetylase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction? | False |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
n/a |
Trial Name | AR-42 |
Novel drug target | Established target |
HDAC1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
3065 | Entrez Gene ID |
CancerCommons Reported Gene Name | HDAC |
HDAC1 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:3.5.1.98 |
3065 | Entrez Gene Id |
ENSG00000116478 | Ensembl Gene Id |
HDAC1 | Gene Symbol |
Target Main Class | Enzymes |
Target Subclass | 3.5.1.98 |
4852 | HUGO Gene ID |
4852 | HUGO Gene Symbol |
histone deacetylase 1 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | 3.5.1.- Histone deacetylases (HDACs) |
GuideToPharmacology Gene Category ID | 848 |
ENZYME |
PA29226 | PharmGKB ID |
HDAC1 | DrugBank Gene Name |
Q13547 | UniProt Accession |
3065 | Entrez Gene Id |
HDAC1 | DrugBank Gene Name |
Q13547 | UniProt Accession |
3065 | Entrez Gene Id |
ENSG00000116478 | Gene Symbol |
HDAC1 | Ensembl Id |
DRUGGABLE GENOME |
3065 | Entrez Gene Id |
HDAC1 | MyCancerGenome Gene Symbol |
HDAC | MyCancerGenome Reported Gene Name |
HDAC1 | Gene Symbol |
RPD3L1 | GENE_SYMBOL |
HDAC1 | GENE_SYMBOL |
Histone deacetylase 1 | UNIPROT |
RPD3L1 | GO Gene Synonym |
TRANSCRIPTION FACTOR BINDING |
HDAC1 | Gene Symbol |
CLINICALLY ACTIONABLE |
HDAC1 | TTD Gene Abbreviation |
T68547 | TTD Target ID |
CLINICALLY ACTIONABLE |