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H2AX Gene Record

  • Summary
  • Interactions
  • Claims
  • H2AX 3014

    Alternate Names:

    3014
    H2A HISTONE FAMILY MEMBER X
    H2AFX
    H2A.X
    H2A/X
    H2AX
    601772
    4739
    ENSG00000188486
    OTTHUMG00000166196
    H2A.X VARIANT HISTONE

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    Publications:

    Trivedi et al., 2005, The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death., Cancer Res.
    Watabe et al., 1996, Identification of histone H2A.X as a growth factor secreted by an androgen-independent subline of mouse mammary carcinoma cells., J. Biol. Chem.
    Kurz et al., 2004, Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species., J. Biol. Chem.
  • ACETYLCYSTEINE   H2AX

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15489221


    Sources:
    NCI

  • TEMOZOLOMIDE   H2AX

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16024643


    Sources:
    NCI

  • TESTOSTERONE   H2AX

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8810267


    Sources:
    NCI

  • DOXORUBICIN   H2AX

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15489221


    Sources:
    NCI

  • Ensembl: ENSG00000188486

    • Version: 101_38

    Alternate Names:
    H2AX Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: H2AFX

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kurz et al., 2004, Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species., J. Biol. Chem.
    Trivedi et al., 2005, The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death., Cancer Res.
    Watabe et al., 1996, Identification of histone H2A.X as a growth factor secreted by an androgen-independent subline of mouse mammary carcinoma cells., J. Biol. Chem.

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21