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GSTT1 Gene Record

  • Summary
  • Interactions
  • Claims
  • GSTT1 2952 Druggable Genome

    Alternate Names:

    2952
    GLUTATHIONE S-TRANSFERASE THETA 1
    GSTT1
    600436
    4641
    ENSG00000184674
    PA183

    Gene Info:

    (0 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Medeiros et al., 2003, Platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma: glutathione S-transferase genetic polymorphisms as predictive biomarkers of disease outcome., Int. J. Clin. Oncol.
    Davies A et al., 2014, Dual glutathione-S-transferase-θ1 and -μ1 gene deletions determine imatinib failure in chronic myeloid leukemia., Clin Pharmacol Ther
    Tsabouri et al., 2004, Treatment of MDS patients with recombinant human erythropoietin and the role of GSTs., J. Exp. Clin. Cancer Res.
    Watanabe et al., 2003, A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus., Clin. Pharmacol. Ther.
    van der Weide K et al., 2017, Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population., Pharmacogenomics J
    Cibeira MT et al., 2011, Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide., Leuk Res
  • EPOETIN BETA   GSTT1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15595630


    Sources:
    NCI

  • TROGLITAZONE   GSTT1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12732844


    Sources:
    PharmGKB

  • AMOXICILLIN   GSTT1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • THALIDOMIDE   GSTT1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21435719


    Sources:
    PharmGKB

  • CLOZAPINE   GSTT1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27168101


    Sources:
    PharmGKB

  • IMATINIB   GSTT1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25188725


    Sources:
    PharmGKB

  • PACLITAXEL   GSTT1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12851839


    Sources:
    NCI

  • ETOPOSIDE   GSTT1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CISPLATIN   GSTT1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12851839


    Sources:
    NCI

  • CARBOPLATIN   GSTT1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PharmGKB: GSTT1

    • Version: 18-August-2020

    Alternate Names:
    PA183 PharmGKB ID

    Gene Info:

    Publications:
    Watanabe et al., 2003, A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus., Clin. Pharmacol. Ther.
    Brüning T et al., 1997, Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene., Arch Toxicol
    Thier R et al., 1998, Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney., Arch Toxicol

  • NCI: GSTT1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Medeiros et al., 2003, Platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma: glutathione S-transferase genetic polymorphisms as predictive biomarkers of disease outcome., Int. J. Clin. Oncol.
    Xiong et al., 2001, Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study., Cancer Res.
    Rojas et al., 2000, Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism., Carcinogenesis

  • HingoraniCasas: ENSG00000184674

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000184674 Gene Symbol
    GSTT1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21