DGIdb - GSTP1 Gene Record

GSTP1 2950 Druggable Genome

Alternate Names:

2950
GLUTATHIONE S-TRANSFERASE PI 1
GSTP1
DFN7
FAEES3
GST3
GSTP
HEL-S-22
PI
134660
4638
ENSG00000084207
OTTHUMG00000137430
P09211
GST class-pi
GSTP1-1
Glutathione S-transferase P
BE0000814
2473
PA29028
T21669

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.5.1.18
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Sawers et al., 2014, Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines., Br. J. Cancer
Khrunin AV et al., 2010, Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients., Pharmacogenomics J
Hour et al., Characterization of chemoresistance mechanisms in a series of cisplatin-resistant transitional carcinoma cell lines., Anticancer Res.
Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics
Booton R et al., 2006, Glutathione-S-transferase P1 isoenzyme polymorphisms, platinum-based chemotherapy, and non-small cell lung cancer., J Thorac Oncol
Kimura S et al., 2004, The relationship of the human glutathione S-transferase P1 polymorphism and chemotherapeutic sensitivity in head and neck squamous carcinoma., Int J Mol Med
Clemens E et al., 2020, Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: The International PanCareLIFE Study., Pharmacogenomics J
Goričar K et al., 2015, Genetic variability of DNA repair mechanisms and glutathione-S-transferase genes influences treatment outcome in osteosarcoma., Cancer Epidemiol
Sugishita M et al., 2016, Pharmacogenetic association between GSTP1 genetic polymorphism and febrile neutropenia in Japanese patients with early breast cancer., Breast Cancer
Zhang BL et al., 2011, Polymorphisms of GSTP1 is associated with differences of chemotherapy response and toxicity in breast cancer., Chin Med J (Engl)
Oliveira AL et al., 2010, GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer., Genet Mol Res
Lin et al., 2001, GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells., Am. J. Pathol.
Ishimoto et al., 2002, Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli., Pharmacogenetics
Anderer et al., 2000, Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia., Pharmacogenetics
Meulendijks D et al., 2017, Pharmacogenetic variants associated with outcome in patients with advanced gastric cancer treated with fluoropyrimidine and platinum-based triplet combinations: a pooled analysis of three prospective studies., Pharmacogenomics J
Lamas MJ et al., 2011, Use of a comprehensive panel of biomarkers to predict response to a fluorouracil-oxaliplatin regimen in patients with metastatic colorectal cancer., Pharmacogenomics
Agostini M et al., 2008, Glutathione S-transferase P1 Ile105Val polymorphism is associated with haematological toxicity in elderly rectal cancer patients receiving preoperative chemoradiotherapy., Drugs Aging
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
He L et al., 2015, Involvement of cytochrome P450 1A1 and glutathione S-transferase P1 polymorphisms and promoter hypermethylation in the progression of anti-tuberculosis drug-induced liver injury: a case-control study., PLoS One
Chan SL et al., 2017, Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients., PLoS One
Wu S et al., 2016, Genetic Polymorphisms of Glutathione S-Transferase P1 (GSTP1) and the Incidence of Anti-Tuberculosis Drug-Induced Hepatotoxicity., PLoS One
Thompson P et al., 2014, Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group., Cancer Chemother Pharmacol
Kavanagh et al., Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer., Int. J. Gynecol. Cancer
Rosen et al., 2003, Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies., Clin. Cancer Res.
Li et al., 1999, [Modulation of multiple drug resistance by nomegestrol acetate and droloxifene in K562/A02]., Zhonghua Xue Ye Xue Za Zhi
Kishi S et al., 2004, Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia., Blood
Dahllöf et al., Characterization of multidrug resistance in SEWA mouse tumor cells: increased glutathione transferase activity and reversal of resistance with verapamil., Anticancer Res.
Kuga et al., 1997, Fibronectin fragment-facilitated retroviral transfer of the glutathione-S-transferase pi gene into CD34+ cells to protect them against alkylating agents., Hum. Gene Ther.
Ramachandran et al., Methylation-mediated silencing of genes is not altered by selenium treatment of prostate cancer cells., Anticancer Res.
Kadokawa et al., 2007, Intracellular balance of oxidative stress and cytoprotective molecules in damaged interlobular bile ducts in autoimmune hepatitis and primary biliary cirrhosis: In situ detection of 8-hydroxydeoxyguanosine and glutathione-S-transferase-pi., Hepatol. Res.
Wild CP et al., 2000, Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia., Int J Cancer
Stoehlmacher et al., 2002, Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer., J. Natl. Cancer Inst.
Watson MA et al., 1998, Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution., Carcinogenesis
Ruzzo A et al., 2007, Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy., J Clin Oncol
Kim HS et al., 2009, Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum compounds: a Korean population-based study., Gynecol Oncol
Georgiadis P et al., 2004, Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke., Toxicol Lett
Dandara C et al., 2002, Genetic polymorphism of cytochrome P450 1A1 (Cyp1A1) and glutathione transferases (M1, T1 and P1) among Africans., Clin Chem Lab Med
Gsur A et al., 2001, Polymorphisms of glutathione-S-transferase genes (GSTP1, GSTM1 and GSTT1) and prostate-cancer risk., Int J Cancer
Garte S et al., 2001, Metabolic gene polymorphism frequencies in control populations., Cancer Epidemiol Biomarkers Prev
McLeod HL et al., 2010, Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741., J Clin Oncol
Lecomte T et al., 2006, Glutathione S-transferase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxaliplatin-based chemotherapy., Clin Cancer Res
Stoehlmacher J et al., 2004, A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer., Br J Cancer
de Waziers et al., 1992, Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao)., Pharmacogenetics
Harkey et al., 2005, Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan., Cancer Invest.
Hansson et al., 1991, Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid., Cancer Res.
Kashfi et al., 1995, Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human., Clin. Pharmacol. Ther.
Kravchenko et al., [The effect of selenium on enzymes metabolizing xenobiotics in rat liver]., Vopr. Med. Khim.
Benson et al., 1985, Effects of disulfiram, diethyldithiocarbamate, bisethylxanthogen, and benzyl isothiocyanate on glutathione transferase activities in mouse organs., Cancer Res.
Mollerup et al., 2001, Lung carcinogenesis: resveratrol modulates the expression of genes involved in the metabolism of PAH in human bronchial epithelial cells., Int. J. Cancer
Zielińska et al., 2005, Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children., J. Pediatr. Hematol. Oncol.
Zhong et al., 2002, Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas., Clin. Cancer Res.
Bakker et al., 2002, Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells., J. Biol. Chem.
Yin JY et al., 2016, Pharmacogenomics of platinum-based chemotherapy sensitivity in NSCLC: toward precision medicine., Pharmacogenomics
Depeille et al., 2005, Combined effects of GSTP1 and MRP1 in melanoma drug resistance., Br. J. Cancer
van Iersel ML et al., 1997, Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1., Chem Biol Interact
Okamura et al., 2000, NADPH/quinone oxidoreductase is a priority target of glioblastoma chemotherapy., Int. J. Oncol.
Deffie et al., 1988, Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia., Cancer Res.
Zhang et al., 1992, A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure., Proc. Natl. Acad. Sci. U.S.A.
Ralat et al., 2006, Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi., Biochemistry
Ishii et al., 2004, GSTP1 affects chemoresistance against camptothecin in human lung adenocarcinoma cells., Cancer Lett.
Mukanganyama S et al., 2002, Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance., Int J Cancer
Adams et al., 1985, Altered mouse bone marrow glutathione and glutathione transferase levels in response to cytotoxins., Cancer Res.
Silva et al., 2004, GSTM1, GSTT1, and GSTP1 genotypes and the genotoxicity of hydroquinone in human lymphocytes., Environ. Mol. Mutagen.
Barańczyk-Kuźma et al., 2004, Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain., Acta Biochim. Pol.
Barańczyk-Kuźma et al., 2001, [Tricyclic antidepressants as inhibitors of brain glutathione-S-transferase]., Pol. Merkur. Lekarski
Kumar et al., 1986, Inhibition of glutathione peroxidase and glutathione transferase in mouse liver by misonidazole., Biochem. Pharmacol.
Breinholt et al., 2000, Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat., Cancer Lett.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Harbottle A et al., 2001, Role of glutathione S-transferase P1, P-glycoprotein and multidrug resistance-associated protein 1 in acquired doxorubicin resistance., Int J Cancer
Munday et al., 2001, Relative activities of organosulfur compounds derived from onions and garlic in increasing tissue activities of quinone reductase and glutathione transferase in rat tissues., Nutr Cancer
Lu WD et al., 2004, A novel antioxidant role for ligandin behavior of glutathione S-transferases: attenuation of the photodynamic effects of hypericin., Biochemistry
Goodrich JM et al., 2012, Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals., Toxicol In Vitro
Nobuoka A et al., 2004, Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid., Gastroenterology
Boerma JS et al., 2011, Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites., Chem Res Toxicol

CANFOSFAMIDE GSTP1

Interaction Score: 4.81

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name TLK286

Novel drug target Novel Target

PMIDs:
16014111 12738715

Sources:
TdgClinicalTrial TTD DrugBank
EZATIOSTAT GSTP1

Interaction Score: 3.85

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ezatiostat hydrochloride, TLK-199,Telintra

Novel drug target Novel Target

PMIDs:
10592235

Sources:
TdgClinicalTrial TTD DrugBank
CARBOCYSTEINE GSTP1

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CIBACRON BLUE GSTP1

Interaction Score: 1.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
EXATECAN MESYLATE GSTP1

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10639573

Sources:
NCI
EZATIOSTAT HYDROCHLORIDE GSTP1

Interaction Score: 0.96

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutathione S-transferase Pi inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
SELENOMETHIONINE GSTP1

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1759407

Sources:
NCI
CHEMBL345292 GSTP1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
DINITROCHLOROBENZENE GSTP1

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22401947

Sources:
DrugBank
MISONIDAZOLE GSTP1

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3753520

Sources:
NCI
OXALIPLATIN GSTP1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10728587 22188361 17409936 12072547 9498276 27995989 17401013 19203783 15093273 12435115 11307147 11751440 20530282 16707601 21449681 15213713

Sources:
NCI PharmGKB
PERFOSFAMIDE GSTP1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9382956

Sources:
NCI
DROLOXIFENE GSTP1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11721384

Sources:
NCI
SULFORAPHANE GSTP1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1549603

Sources:
NCI
IRINOTECAN HYDROCHLORIDE GSTP1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10639573

Sources:
NCI
DITIOCARB GSTP1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2992773

Sources:
NCI
ISONIAZID GSTP1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25798582 29036176 27281183

Sources:
PharmGKB
LYCOPENE GSTP1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10806309

Sources:
NCI
DECITABINE GSTP1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11948118 11960994

Sources:
NCI
CLOMIPRAMINE GSTP1

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15094841 11899840 10592235

Sources:
DrugBank
CHEMBL1234276 GSTP1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
EXISULIND GSTP1

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15300575

Sources:
DrugBank
IFOSFAMIDE GSTP1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16282887

Sources:
NCI
GARLIC GSTP1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11962257

Sources:
NCI
RIFAMPIN GSTP1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25798582 29036176 27281183

Sources:
PharmGKB
BUSULFAN GSTP1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15779864

Sources:
NCI PharmGKB
PYRIMETHAMINE GSTP1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11807801

Sources:
PharmGKB
MELPHALAN GSTP1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15779864 1988111

Sources:
NCI
PLATINUM GSTP1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27462924

Sources:
PharmGKB
HYPERICIN GSTP1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15461448

Sources:
DrugBank
EPIRUBICIN GSTP1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25008867 21362365 20568049

Sources:
PharmGKB
THIOTEPA GSTP1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HYDROQUINONE GSTP1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15141365

Sources:
NCI
ADRIAMYCIN GSTP1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2897875

Sources:
NCI
CYCLOPHOSPHAMIDE GSTP1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19786980 25008867 21362365 22188361 20568049 9382956

Sources:
NCI PharmGKB
VITAMIN E GSTP1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17029404

Sources:
NCI
GLUTATHIONE GSTP1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17465221 17517071

Sources:
DrugBank
CISPLATIN GSTP1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19786980 25010864 11062746 22188361 17409936 15254763 31666714 25592234

Sources:
NCI PharmGKB CIViC
PREDNISONE GSTP1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11186134

Sources:
NCI
TROGLITAZONE GSTP1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21639118

Sources:
DrugBank
OMEPRAZOLE GSTP1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8529327

Sources:
NCI
AZACITIDINE GSTP1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11696442

Sources:
NCI
CAMPTOTHECIN GSTP1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15500952

Sources:
NCI
CURCUMIN GSTP1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15999103 9463521

Sources:
NCI DrugBank
CARBOPLATIN GSTP1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25010864 12360105

Sources:
NCI CIViC
BLEOMYCIN GSTP1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CYTARABINE GSTP1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3978635

Sources:
NCI
VERAPAMIL GSTP1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3566185

Sources:
NCI
ETOPOSIDE GSTP1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12969965

Sources:
PharmGKB
FLUOROURACIL GSTP1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27995989 21449681 18540691

Sources:
PharmGKB
LEUCOVORIN GSTP1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
RESVERATROL GSTP1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11279601

Sources:
NCI
DAUNORUBICIN GSTP1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25119182

Sources:
PharmGKB
CLOZAPINE GSTP1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21639118

Sources:
DrugBank
DOCETAXEL GSTP1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10639573

Sources:
NCI
DEXAMETHASONE GSTP1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1302037

Sources:
NCI
DOXORUBICIN GSTP1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11351295

Sources:
PharmGKB
PACLITAXEL GSTP1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25010864

Sources:
CIViC
ALCOHOL GSTP1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1302037

Sources:
NCI

Ensembl: ENSG00000084207
- Version: 101_38
Alternate Names:

GSTP1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P09211
- Version: January-2014
Alternate Names:

GSTP1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.5.1.18

Publications:

PharmGKB: GSTP1

Version: 18-August-2020

Alternate Names:

PA29028 PharmGKB ID

Gene Info:

Publications:

Yin JY et al., 2016, Pharmacogenomics of platinum-based chemotherapy sensitivity in NSCLC: toward precision medicine., Pharmacogenomics

Wild CP et al., 2000, Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia., Int J Cancer

Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics

CIViC: GSTP1

Version: 14-September-2020

Alternate Names:

2950 Entrez Gene ID

2473 CIViC Gene ID

Gene Info:

Publications:

Chen et al., 2010, Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma., Cancer Sci.

Sawers et al., 2014, Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines., Br. J. Cancer

DrugBank: BE0000814

Version: 5.1.7

Alternate Names:

GSTP1 DrugBank Gene Name

P09211 UniProt Accession

2950 Entrez Gene Id

Gene Info:

Publications:

Boerma JS et al., 2011, Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites., Chem Res Toxicol

van Iersel ML et al., 1997, Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1., Chem Biol Interact

Barańczyk-Kuźma et al., 2004, Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain., Acta Biochim. Pol.

NCI: GSTP1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Anderer et al., 2000, Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia., Pharmacogenetics

Stoehlmacher et al., 2002, Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer., J. Natl. Cancer Inst.

de Waziers et al., 1992, Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao)., Pharmacogenetics

HingoraniCasas: ENSG00000084207
- Version: 31-May-2017
Alternate Names:

ENSG00000084207 Gene Symbol

GSTP1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: FAEES3
- Version: chembl_23
Alternate Names:

GST3 GENE_SYMBOL

GSTP1 GENE_SYMBOL

Glutathione S-transferase P UNIPROT

Gene Info:

Publications:
Pharos: GSTP1
- Version: 03-September-2020
Alternate Names:

Glutathione S-transferase P Gene Name

P09211 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: GSTP1
- Version: 11-November-2018
Alternate Names:

GSTP1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Glutathione S-transferase P
- Version: 2020.06.01
Alternate Names:

GSTP1 TTD Gene Abbreviation

T21669 TTD Target ID

Gene Info:

Publications:

Trial Name	ezatiostat hydrochloride, TLK-199,Telintra
Novel drug target	Novel Target

Direct Interaction	yes
Mechanism of Interaction	Glutathione S-transferase Pi inhibitor

GSTP1	DrugBank Gene Name
P09211	UniProt Accession
2950	Entrez Gene Id

GST3	GENE_SYMBOL
GSTP1	GENE_SYMBOL
Glutathione S-transferase P	UNIPROT

GSTP1 Gene Record

GSTP1 2950 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name TLK286 Novel drug target Novel Target

PMIDs: 16014111 12738715

Sources: TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ezatiostat hydrochloride, TLK-199,Telintra Novel drug target Novel Target

PMIDs: 10592235

Sources: TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10639573

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutathione S-transferase Pi inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1759407

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22401947

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3753520

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10728587 22188361 17409936 12072547 9498276 27995989 17401013 19203783 15093273 12435115 11307147 11751440 20530282 16707601 21449681 15213713

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9382956

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11721384

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1549603

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10639573

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2992773

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25798582 29036176 27281183

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10806309

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name TLK286

Novel drug target Novel Target

PMIDs:
16014111 12738715

Sources:
TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ezatiostat hydrochloride, TLK-199,Telintra

Novel drug target Novel Target

PMIDs:
10592235

Sources:
TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10639573

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutathione S-transferase Pi inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
1759407

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
22401947

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
3753520

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10728587 22188361 17409936 12072547 9498276 27995989 17401013 19203783 15093273 12435115 11307147 11751440 20530282 16707601 21449681 15213713

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9382956

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11721384

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1549603

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10639573

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2992773

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25798582 29036176 27281183

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10806309

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11948118 11960994

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15094841 11899840 10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15300575

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16282887

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11962257

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25798582 29036176 27281183

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15779864