DGIdb - GSR Gene Record

GSR 2936 Druggable Genome

Alternate Names:

2936
GLUTATHIONE-DISULFIDE REDUCTASE
GSR
HEL-75
HEL-S-122m
138300
4623
ENSG00000104687
OTTHUMG00000163946
P00390
GSHR_HUMAN
GLUTATHIONE REDUCTASE, MITOCHONDRIAL
GLUR
GRase
GRD1
GR
BE0000648
2613
GLUTATHIONE REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.8.1.7) (GR) (GRASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00390]
PA29014
Glutamine receptor
T21447
NM_000637
NP_000628

Gene Info:

Target Class	Enzymes
Target Subclass	EC:1.8.1.7
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
Interpro Acc	IPR001327
Interpro Type	Domain
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	Pyr_OxRdtase_NAD-bd_dom
Target Subclass	1.8.1.7
Target Main Class	Enzymes
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	1.-.-.- Oxidoreductases
GuideToPharmacology Gene Category ID	840

(10 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
ENZYME

Publications:

Babych et al., 2000, [The effect of thyroxine on the enzymatic activity of the energy metabolism and antioxidant system in the neutrophilic granulocytes of piglets]., Fiziol Zh
de Cavanagh et al., 2000, Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Kurata et al., 1992, Effects of phenol compounds, glutathione analogues and a diuretic drug on glutathione S-transferase, glutathione reductase and glutathione peroxidase from canine erythrocytes., Comp. Biochem. Physiol., B
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J
Erat et al., 2003, In vitro effects of some antibiotics on glutathione reductase from sheep liver., J Enzyme Inhib Med Chem
Erat et al., 2005, Effects of some antibiotics on glutathione reductase activities from human erythrocytes in vitro and from rat erythrocytes in vivo., J Enzyme Inhib Med Chem
Vallyathan et al., 1992, Enhanced generation of free radicals from phagocytes induced by mineral dusts., Am. J. Respir. Cell Mol. Biol.
Powell et al., 1987, Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity., J. Pharmacol. Exp. Ther.
Akella et al., Pyridine nucleotide flux and glutathione oxidation in the cultured rat conceptus., Reprod. Toxicol.
Brodie et al., 1992, Glutathione disulfide reduction in tumor mitochondria after t-butyl hydroperoxide treatment., Chem. Biol. Interact.
Kirsch et al., 2002, Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA., Antisense Nucleic Acid Drug Dev.
Jopperi-Davis et al., 2004, Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats., Toxicol. Lett.
Doroshenko et al., 2004, The glutathione reductase inhibitor carmustine induces an influx of Ca2+ in PC12 cells., Eur. J. Pharmacol.
Puglia et al., 1984, Inhibition of cellular antioxidants: a possible mechanism of toxic cell injury., Environ. Health Perspect.
Tamura T et al., 1996, Mitochondrial targeting of glutathione reductase requires a leader sequence., Biochem Biophys Res Commun
Bajcetic et al., 2008, Effects of carvedilol on left ventricular function and oxidative stress in infants and children with idiopathic dilated cardiomyopathy: a 12-month, two-center, open-label study., Clin Ther
Agnihotri et al., Role of oxidative stress in lansoprazole-mediated gastric and hepatic protection in Wistar rats., Indian J Gastroenterol
Ozmen et al., 2004, Effects of antiemetic drugs on glucose 6-phosphate dehydrogenase and some antioxidant enzymes., Pharmacol. Res.
Mulcahy, 1986, Carbamoylation, inhibition of glutathione reductase and chemopotentiation of nitrosoureas by misonidazole., Int. J. Radiat. Oncol. Biol. Phys.
Brocardo et al., 2007, Zinc attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain., Toxicol. Sci.
Guruvayoorappan et al., 2006, Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo., J Basic Clin Physiol Pharmacol
Maity et al., 2008, Antioxidant responses of the earthworm Lampito mauritii exposed to Pb and Zn contaminated soil., Environ. Pollut.
Markaryan et al., 2006, Peroxide-eliminating oxidoreductases as biosensors of antioxidant components of medicinal plants., Bull. Exp. Biol. Med.
Messarah et al., 2007, The impact of thyroid activity variations on some oxidizing-stress parameters in rats., C. R. Biol.
Stankiewicz et al., 2002, Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats., Drug Metabol Drug Interact
Aon et al., 2007, Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status., J. Biol. Chem.
Cheng et al., 2007, The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila., Biochemistry
Wan et al., 2007, Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice., Plant Cell Rep.
Knapp et al., 2007, Evidence for an additional disulfide reduction pathway in Escherichia coli., J. Biosci. Bioeng.
Gazaryan et al., 2007, Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition., J. Biol. Chem.
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
Smith SD et al., 2004, Using immobilized metal affinity chromatography, two-dimensional electrophoresis and mass spectrometry to identify hepatocellular proteins with copper-binding ability., J Proteome Res
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

CHEMBL135287 GSR

Interaction Score: 4.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CARMUSTINE GSR

Interaction Score: 2.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name polifeprosan 20/carmustine,Gliadel

Novel drug target Established target

Mechanism of Interaction Glutathione reductase inhibitor

PMIDs:
1312851 3806383 10378469 1394620 12477282 15104113 15321730 6094175

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
ALANYL GLUTAMINE GSR

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OXIGLUTATIONE GSR

Interaction Score: 1.98

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
8651901

Sources:
DrugBank GuideToPharmacology ChemblInteractions
CHEMBL1160508 GSR

Interaction Score: 1.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
MISONIDAZOLE GSR

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3759562

Sources:
NCI
LEVOFLOXACIN GSR

Interaction Score: 1.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15008519

Sources:
NCI
AMIFOSTINE GSR

Interaction Score: 0.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12751907

Sources:
NCI
CEFOTAXIME GSR

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15895687

Sources:
NCI
OFLOXACIN GSR

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15008519

Sources:
NCI
THYROXINE GSR

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11059392

Sources:
NCI
GLUTATHIONE GSR

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17327255 17338281 17512104 17369902 17303537

Sources:
DrugBank
ONDANSETRON GSR

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15458770

Sources:
NCI
FLAVIN ADENIN DINUCLEOTIDE GSR

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
ENALAPRIL GSR

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10712274

Sources:
NCI
LANSOPRAZOLE GSR

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17704577

Sources:
NCI
CARVEDILOL GSR

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18498919

Sources:
NCI
CANNABIDIOL GSR

Interaction Score: 0.11

Interaction Types & Directionality:

stimulator (activating)

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank
NABIXIMOLS GSR

Interaction Score: 0.11

Interaction Types & Directionality:

stimulator (activating)

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank
CHEMBL1161866 GSR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17540766 17550271 17053903 17502280 17565998

Sources:
DrugBank
CARBOPLATIN GSR

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26194361

Sources:
PharmGKB
QUERCETIN GSR

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1478066

Sources:
NCI
COPPER GSR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15359738

Sources:
DrugBank

Ensembl: ENSG00000104687
- Version: 101_38
Alternate Names:

GSR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P00390
- Version: January-2014
Alternate Names:

GSR Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.8.1.7

Publications:
TEND: P00390
- Version: 01-August-2011
Alternate Names:

ENSG00000104687 Ensembl Gene Id

P00390 Uniprot Accession

GSHR_HUMAN Uniprot Id

Gene Info:

Target Subclass 1.8.1.7

Target Main Class Enzymes

Publications:
HopkinsGroom: P00390
- Version: 11-September-2012
Alternate Names:

GLUTATHIONE REDUCTASE, MITOCHONDRIAL Uniprot Protein Name

2936 Entrez Gene Id

GSR Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Name Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain

Interpro Acc IPR001327

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000104687
- Version: 26-July-2011
Alternate Names:

GSR Display Id

GLUTATHIONE REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.8.1.7) (GR) (GRASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00390] Description

ENSG00000104687 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 2936
- Version: 29-September-2020
Alternate Names:

4623 HUGO Gene ID

4623 HUGO Gene Symbol

glutathione-disulfide reductase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1.-.-.- Oxidoreductases

GuideToPharmacology Gene Category ID 840

Gene Categories:

ENZYME

Publications:
PharmGKB: GSR
- Version: 18-August-2020
Alternate Names:

PA29014 PharmGKB ID

Gene Info:

Publications:

He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J

DrugBank: BE0000648

Version: 5.1.7

Alternate Names:

GSR DrugBank Gene Name

P00390 UniProt Accession

2936 Entrez Gene Id

Gene Info:

Publications:

Brocardo et al., 2007, Zinc attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain., Toxicol. Sci.

Guruvayoorappan et al., 2006, Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo., J Basic Clin Physiol Pharmacol

Maity et al., 2008, Antioxidant responses of the earthworm Lampito mauritii exposed to Pb and Zn contaminated soil., Environ. Pollut.

NCI: GSR

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Babych et al., 2000, [The effect of thyroxine on the enzymatic activity of the energy metabolism and antioxidant system in the neutrophilic granulocytes of piglets]., Fiziol Zh

de Cavanagh et al., 2000, Enalapril and captopril enhance glutathione-dependent antioxidant defenses in mouse tissues., Am. J. Physiol. Regul. Integr. Comp. Physiol.

Bajcetic et al., 2008, Effects of carvedilol on left ventricular function and oxidative stress in infants and children with idiopathic dilated cardiomyopathy: a 12-month, two-center, open-label study., Clin Ther

HingoraniCasas: ENSG00000104687
- Version: 31-May-2017
Alternate Names:

ENSG00000104687 Gene Symbol

GSR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: GLUR
- Version: chembl_23
Alternate Names:

GRD1 GENE_SYMBOL

GSR GENE_SYMBOL

Glutathione reductase, mitochondrial UNIPROT

Gene Info:

Publications:
Pharos: GSR
- Version: 03-September-2020
Alternate Names:

Glutathione reductase, mitochondrial Gene Name

P00390 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: GSR
- Version: 05-September-2020
Alternate Names:

GLUR GO Gene Synonym

GRD1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Glutamine receptor
- Version: 2020.06.01
Alternate Names:

GluR TTD Gene Abbreviation

T21447 TTD Target ID

Gene Info:

Publications:

Trial Name	polifeprosan 20/carmustine,Gliadel
Novel drug target	Established target
Mechanism of Interaction	Glutathione reductase inhibitor

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

ENSG00000104687	Ensembl Gene Id
P00390	Uniprot Accession
GSHR_HUMAN	Uniprot Id

GLUTATHIONE REDUCTASE, MITOCHONDRIAL	Uniprot Protein Name
2936	Entrez Gene Id
GSR	Uniprot Gene Name

GSR	Display Id
GLUTATHIONE REDUCTASE, MITOCHONDRIAL PRECURSOR (EC 1.8.1.7) (GR) (GRASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00390]	Description
ENSG00000104687	Ensembl Gene Id

4623	HUGO Gene ID
4623	HUGO Gene Symbol
glutathione-disulfide reductase	HUGO Gene Name

GSR	DrugBank Gene Name
P00390	UniProt Accession
2936	Entrez Gene Id

GRD1	GENE_SYMBOL
GSR	GENE_SYMBOL
Glutathione reductase, mitochondrial	UNIPROT

Glutathione reductase, mitochondrial	Gene Name
P00390	UniProt ID

inhibitor (inhibitory)
substrate

GSR Gene Record

GSR 2936 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name polifeprosan 20/carmustine,Gliadel Novel drug target Established target Mechanism of Interaction Glutathione reductase inhibitor

PMIDs: 1312851 3806383 10378469 1394620 12477282 15104113 15321730 6094175

Sources: TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory) substrate

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 8651901

Sources: DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3759562

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15008519

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12751907

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15895687

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15008519

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11059392

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17327255 17338281 17512104 17369902 17303537

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15458770

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10712274

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17704577

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18498919

Sources: NCI

Interaction Types & Directionality: stimulator (activating)

Interaction Info:

PMIDs: 26264914

Sources: DrugBank

Interaction Types & Directionality: stimulator (activating)

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name polifeprosan 20/carmustine,Gliadel

Novel drug target Established target

Mechanism of Interaction Glutathione reductase inhibitor

PMIDs:
1312851 3806383 10378469 1394620 12477282 15104113 15321730 6094175

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
8651901

Sources:
DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
3759562

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15008519

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12751907

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15895687

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15008519

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11059392

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17327255 17338281 17512104 17369902 17303537

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15458770

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10712274

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17704577

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18498919

Sources:
NCI

Interaction Types & Directionality:

stimulator (activating)

PMIDs:
26264914

Sources:
DrugBank

Interaction Types & Directionality:

stimulator (activating)

PMIDs:
26264914

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17540766 17550271 17053903 17502280 17565998

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
26194361

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
1478066

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15359738

Sources:
DrugBank

Alternate Names:

GSR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

GSR Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.8.1.7

Alternate Names:

ENSG00000104687 Ensembl Gene Id

P00390 Uniprot Accession

GSHR_HUMAN Uniprot Id

Gene Info:

Target Subclass 1.8.1.7

Target Main Class Enzymes

Alternate Names:

GLUTATHIONE REDUCTASE, MITOCHONDRIAL Uniprot Protein Name

2936 Entrez Gene Id

GSR Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Name Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain

Interpro Acc IPR001327

Gene Categories:

DRUGGABLE GENOME