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GSK3B Gene Record

  • Summary
  • Interactions
  • Claims
  • GSK3B 2932 Druggable GenomeClinically Actionable

    Alternate Names:

    2932
    GLYCOGEN SYNTHASE KINASE 3 BETA
    GSK3B
    605004
    4617
    ENSG00000082701
    OTTHUMG00000133765
    P49841
    GSK3B_HUMAN
    GLYCOGEN SYNTHASE KINASE-3 BETA
    GSK-3 beta
    Serine/threonine-protein kinase GSK3B
    GLYCOGEN SYNTHASE KINASE-3 BETA (EC 2.7.1.37) (GSK-3 BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P49841]
    PA29009
    GSK-3B
    T70977
    -

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.11.26
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Human Readable Name KINASE
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Acc IPR002290
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Martinez A et al., 2011, Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment., Int J Alzheimers Dis
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Ha do T et al., 2009, Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells., Bioorg Med Chem Lett
    Zou H et al., 2010, Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode., J Med Chem
    Zhang P et al., 2014, Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3β (GSK-3β) with cellular activity of promoting glucose uptake., Bioorg Med Chem Lett
    Schmöle AC et al., 2010, Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells., Bioorg Med Chem
    Borsotto et al., 2007, PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder., Pharmacogenomics J.
    Adli et al., 2007, Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta -50T/C single nucleotide polymorphism., Biol. Psychiatry
    O'Brien et al., 2009, Validating GSK3 as an in vivo target of lithium action., Biochem. Soc. Trans.
    Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med
    Lin YF et al., 2013, Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium., J Affect Disord
    McCarthy MJ et al., 2011, Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder., Genes Brain Behav
    McCarthy MJ et al., 2010, Pharmacogenetics of lithium response in bipolar disorder., Pharmacogenomics
    Rao KV et al., 2006, Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases., J Nat Prod
    Tsai SJ et al., 2008, Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder., Pharmacogenomics J
    Bidon-Chanal A et al., 2013, Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin., Eur J Med Chem
    Hudkins RL et al., 2012, Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent., J Med Chem
    Kang NS et al., 2009, Identification of small molecules that inhibit GSK-3beta through virtual screening., Bioorg Med Chem Lett
    Chao WR et al., 2007, Computer-aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling., J Med Chem
  • CHEMBL449063   GSK3B

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19081248


    Sources:
    DTC

  • SITOGLUSIDE   GSK3B

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19716700


    Sources:
    DTC

  • CHEMBL1081326   GSK3B

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19716700


    Sources:
    DTC

  • PALINURIN   GSK3B

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23354070


    Sources:
    DTC

  • BETA-SITOSTEROL   GSK3B

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19716700


    Sources:
    DTC

  • PALBINONE   GSK3B

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19716700


    Sources:
    DTC

  • MANZAMINE A   GSK3B

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16872140


    Sources:
    DTC

  • TIDEGLUSIB   GSK3B

    Interaction Score: 2.69

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glycogen synthase kinase-3 beta inhibitor
    Trial Name tideglusib, NP-12,Nypta

    PMIDs:
    21760986


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • CHEMBL259850   GSK3B

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423 10592235


    Sources:
    DTC TTD

  • SR-13668   GSK3B

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17602463


    Sources:
    DTC

  • OLEANOLIC_ACID   GSK3B

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19716700


    Sources:
    DTC

  • BETULINIC ACID   GSK3B

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19716700


    Sources:
    DTC

  • LITHIUM CITRATE   GSK3B

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glycogen synthase kinase-3 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LITHIUM CARBONATE   GSK3B

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glycogen synthase kinase-3 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SB-216763   GSK3B

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20030405 25467150 20708937


    Sources:
    DTC

  • CHEMBL588859   GSK3B

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1276446   GSK3B

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CEP-11981   GSK3B

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22148921


    Sources:
    DTC

  • CHIR-99021   GSK3B

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC TTD

  • LITHIUM   GSK3B

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16733521 17628506 19754466 24885933 23021822 21781277 21047205


    Sources:
    PharmGKB

  • URSOLIC ACID   GSK3B

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19716700


    Sources:
    DTC

  • AZD-1080   GSK3B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glycogen synthase kinase-3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DTC ChemblInteractions

  • AZAKENPAULLONE   GSK3B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AT-9283   GSK3B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • ALSTERPAULLONE   GSK3B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10592235 17016423 17139284


    Sources:
    DTC

  • BMS-387032   GSK3B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LY-2090314   GSK3B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glycogen synthase kinase-3 beta inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • FLUOXETINE   GSK3B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18195729


    Sources:
    PharmGKB

  • CITALOPRAM   GSK3B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18195729


    Sources:
    PharmGKB

  • CI-1040   GSK3B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • KENPAULLONE   GSK3B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC TTD

  • SB-203580   GSK3B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL546797   GSK3B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL541400   GSK3B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW843682X   GSK3B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GO-6976   GSK3B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL379975   GSK3B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GSK-269962A   GSK3B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • JNJ-7706621   GSK3B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SOTRASTAURIN   GSK3B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   GSK3B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL225519   GSK3B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   GSK3B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   GSK3B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   GSK3B

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   GSK3B

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000082701

    • Version: 101_38

    Alternate Names:
    GSK3B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P49841

    • Version: January-2014

    Alternate Names:
    GSK3B Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.26

    Publications:

  • RussLampel: ENSG00000082701

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000082701 Ensembl Gene Id
    GLYCOGEN SYNTHASE KINASE-3 BETA (EC 2.7.1.37) (GSK-3 BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P49841] Description
    GSK3B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P49841

    • Version: 11-September-2012

    Alternate Names:
    P49841 Uniprot Accession
    2932 Entrez Gene Id
    GSK3B_HUMAN Uniprot Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • PharmGKB: GSK3B

    • Version: 18-August-2020

    Alternate Names:
    PA29009 PharmGKB ID

    Gene Info:

    Publications:
    Tsai SJ et al., 2008, Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder., Pharmacogenomics J
    McCarthy MJ et al., 2011, Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder., Genes Brain Behav
    Lin YF et al., 2013, Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium., J Affect Disord

  • DTC: GSK3B

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Rao KV et al., 2006, Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases., J Nat Prod
    Ha do T et al., 2009, Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells., Bioorg Med Chem Lett
    Chao WR et al., 2007, Computer-aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling., J Med Chem

  • TALC: GSK3B

    • Version: 12-May-2016

    Alternate Names:
    GSK3B Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: GSK3B

    • Version: chembl_23

    Alternate Names:
    GSK3B GENE_SYMBOL
    Glycogen synthase kinase-3 beta UNIPROT
    Serine/threonine-protein kinase GSK3B UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000082701

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000082701 Gene Symbol
    GSK3B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: GSK3B

    • Version: 27-Jun-2013

    Alternate Names:
    2932 Gene ID
    - dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Glycogen synthase kinase-3 beta

    • Version: 2020.06.01

    Alternate Names:
    GSK-3B TTD Gene Abbreviation
    T70977 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: GSK3B

    • Version: 01-February-2022

    Alternate Names:
    Glycogen synthase kinase-3 beta Gene Name
    P49841 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • MskImpact: GSK3B

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: GSK3B

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: GSK3B

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: GSK3B

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21