• GSK3A 2931 Druggable Genome

    Alternate Names:

    2931
    GLYCOGEN SYNTHASE KINASE 3 ALPHA
    GSK3A
    606784
    4616
    ENSG00000105723
    OTTHUMG00000150722
    P49840
    GSK3A_HUMAN
    2029
    GLYCOGEN SYNTHASE KINASE-3 ALPHA (EC 2.7.1.37) (GSK-3 ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P49840]
    GLYCOGEN SYNTHASE KINASE-3 ALPHA
    NP_063937
    NM_019884
    GSK-3 alpha
    Serine/threonine-protein kinase GSK3A
    T76910
    GSK-3A
    -
    BE0009446

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE
    Interpro Type Domain
    Interpro Acc IPR002290
    Uniprot Status Swiss-Prot
    GuideToPharmacology Gene Category Name GSK subfamily
    GuideToPharmacology Gene Category ID 509
    Target Class Enzymes
    Target Subclass EC:2.7.11.26
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR
  • Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name tideglusib, NP-12,Nypta
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC TTD

  • Interaction Score: 0.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glycogen synthase kinase-3 inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glycogen synthase kinase-3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glycogen synthase kinase-3 alpha inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glycogen synthase kinase-3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC TTD

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

    • Version: 101_38

    Alternate Names:
    GSK3A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: January-2014

    Alternate Names:
    GSK3A Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.26

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GSK3A Display Id
    ENSG00000105723 Ensembl Gene Id
    GLYCOGEN SYNTHASE KINASE-3 ALPHA (EC 2.7.1.37) (GSK-3 ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P49840] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    GSK3A_HUMAN Uniprot Id
    ENSG00000105723 Ensembl Gene Id
    P49840 Uniprot Accession

    Gene Info:
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    4616 HUGO Gene ID
    4616 HUGO Gene Symbol
    glycogen synthase kinase 3 alpha HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name GSK subfamily
    GuideToPharmacology Gene Category ID 509

    Gene Categories:
    ENZYME

    Publications:

    • Version: 5.1.7

    Alternate Names:
    GSK3A DrugBank Gene Name
    P49840 UniProt Accession
    2931 Entrez Gene Id

    Gene Info:

    • Version: chembl_23

    Alternate Names:
    GSK3A GENE_SYMBOL
    Glycogen synthase kinase-3 alpha UNIPROT
    Serine/threonine-protein kinase GSK3A UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105723 Gene Symbol
    GSK3A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 03-September-2020

    Alternate Names:
    Glycogen synthase kinase-3 alpha Gene Name
    P49840 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    2931 Gene ID
    - dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    GSK-3A TTD Gene Abbreviation
    T76910 TTD Target ID

    Gene Info:

    Publications:

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications: