DGIdb - GRM1 Gene Record

GRM1 2911 Druggable Genome

Alternate Names:

2911
GLUTAMATE METABOTROPIC RECEPTOR 1
GRM1
GPRC1A
MGLU1
MGLUR1
PPP1R85
SCAR13
604473
4593
ENSG00000152822
OTTHUMG00000015752
GRM1_HUMAN
Q13255
METABOTROPIC GLUTAMATE RECEPTOR 1
METABOTROPIC GLUTAMATE RECEPTOR 1 PRECURSOR (MGLUR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13255]
T27137
GRM1A
MGLUR1A
SCA44

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Short Name	GPCR_3
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Interpro Name	GPCR, family 3
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000337
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TRANSPORTER
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Pula et al., 2004, Agonist-independent internalization of metabotropic glutamate receptor 1a is arrestin- and clathrin-dependent and is suppressed by receptor inverse agonists., J. Neurochem.
Frølund S et al., 2010, Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists., J Med Chem
Sharif et al., 2002, Attenuation of morphine tolerance after antisense oligonucleotide knock-down of spinal mGluR1., Br. J. Pharmacol.
Vigh et al., 2003, Intracellular calcium release resulting from mGluR1 receptor activation modulates GABAA currents in wide-field retinal amacrine cells: a study with caffeine., Eur. J. Neurosci.

PHILANTHOTOXIN 343 GRM1

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20873775

Sources:
DTC
INOSITOL GRM1

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15140199

Sources:
NCI
CAFFEINE GRM1

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12814357

Sources:
NCI
MORPHINE GRM1

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12110611

Sources:
NCI

Ensembl: ENSG00000152822
- Version: 101_38
Alternate Names:

GRM1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000152822
- Version: 26-July-2011
Alternate Names:

GRM1 Display Id

METABOTROPIC GLUTAMATE RECEPTOR 1 PRECURSOR (MGLUR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13255] Description

ENSG00000152822 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: Q13255
- Version: 11-September-2012
Alternate Names:

ENSG00000152822 Ensembl Gene Id

Q13255 Uniprot Accession

2911 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Type Family

Interpro Name GPCR, family 3

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

NCI: GRM1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Bajkowska et al., Effect of chronic antidepressant or electroconvulsive shock treatment on mGLuR1a immunoreactivity expression in the rat hippocampus., Pol J Pharmacol

Sharif et al., 2002, Attenuation of morphine tolerance after antisense oligonucleotide knock-down of spinal mGluR1., Br. J. Pharmacol.

Heinbockel et al., 2004, Regulation of main olfactory bulb mitral cell excitability by metabotropic glutamate receptor mGluR1., J. Neurophysiol.

DTC: GRM1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Frølund S et al., 2010, Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists., J Med Chem

HingoraniCasas: ENSG00000152822
- Version: 31-May-2017
Alternate Names:

ENSG00000152822 Gene Symbol

GRM1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: GRM1
- Version: 19.3
Alternate Names:

ENSG00000152822 Ensembl Gene ID

GPRC1A Human Protein Atlas Gene Synonym

mGlu1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

TRANSPORTER, G PROTEIN COUPLED RECEPTOR

Publications:
GO: GRM1
- Version: 01-February-2022
Alternate Names:

GPRC1A GO Gene Synonym

MGLUR1 GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: GRM1
- Version: 27-Jun-2013
Alternate Names:

2911 Gene ID

GPRC1A dGene Synonym

GRM1A dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Metabotropic glutamate receptor 1
- Version: 2020.06.01
Alternate Names:

mGluR1 TTD Gene Abbreviation

T27137 TTD Target ID

Gene Info:

Publications:

GRM1	Display Id
METABOTROPIC GLUTAMATE RECEPTOR 1 PRECURSOR (MGLUR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13255]	Description
ENSG00000152822	Ensembl Gene Id

GRM1 Gene Record

GRM1 2911 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PHILANTHOTOXIN 343 GRM1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20873775

Sources: DTC

INOSITOL GRM1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15140199

Sources: NCI

CAFFEINE GRM1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12814357

Sources: NCI

MORPHINE GRM1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12110611

Sources: NCI

Ensembl: ENSG00000152822

Alternate Names: GRM1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000152822

Alternate Names: GRM1 Display Id METABOTROPIC GLUTAMATE RECEPTOR 1 PRECURSOR (MGLUR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13255] Description ENSG00000152822 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q13255

Alternate Names: ENSG00000152822 Ensembl Gene Id Q13255 Uniprot Accession 2911 Entrez Gene Id

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Type Family Interpro Name GPCR, family 3

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

NCI: GRM1

Alternate Names:

Gene Info:

DTC: GRM1

Alternate Names:

Gene Info:

Publications: Frølund S et al., 2010, Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists., J Med Chem

HingoraniCasas: ENSG00000152822

Alternate Names: ENSG00000152822 Gene Symbol GRM1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: GRM1

Alternate Names: ENSG00000152822 Ensembl Gene ID GPRC1A Human Protein Atlas Gene Synonym mGlu1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: TRANSPORTER, G PROTEIN COUPLED RECEPTOR

Publications:

GO: GRM1

Alternate Names: GPRC1A GO Gene Synonym MGLUR1 GO Gene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

dGene: GRM1

Alternate Names: 2911 Gene ID GPRC1A dGene Synonym GRM1A dGene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

TTD: Metabotropic glutamate receptor 1

Alternate Names: mGluR1 TTD Gene Abbreviation T27137 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20873775

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15140199

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12814357

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12110611

Sources:
NCI

Alternate Names:

GRM1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

GRM1 Display Id

METABOTROPIC GLUTAMATE RECEPTOR 1 PRECURSOR (MGLUR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13255] Description

ENSG00000152822 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000152822 Ensembl Gene Id

Q13255 Uniprot Accession

2911 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Type Family

Interpro Name GPCR, family 3

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

Frølund S et al., 2010, Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists., J Med Chem

Alternate Names:

ENSG00000152822 Gene Symbol

GRM1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000152822 Ensembl Gene ID

GPRC1A Human Protein Atlas Gene Synonym

mGlu1 Human Protein Atlas Gene Synonym

Gene Categories:

TRANSPORTER, G PROTEIN COUPLED RECEPTOR

Alternate Names:

GPRC1A GO Gene Synonym

MGLUR1 GO Gene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

2911 Gene ID

GPRC1A dGene Synonym

GRM1A dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

mGluR1 TTD Gene Abbreviation

T27137 TTD Target ID