• Interaction Score: 2.98

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Namenda
    Novel drug target Established target
    Trial Name memantine

  • Interaction Score: 2.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name AVP-923
    Novel drug target Established target
    Trial Name morphine/dextromethorphan,MorphiDex

  • Interaction Score: 2.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

  • Interaction Score: 1.82

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name amitriptyline + ketamine,Epicept NP-1
    Novel drug target Established target
    Trial Name nasal ketamine,Ereska

  • Interaction Score: 0.89

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

  • Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name acamprosate,Campral
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name neramexane mesylate
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes
    Trial Name AM-101

    PMIDs:
    None found


  • Interaction Score: 0.61

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name AZD-6765
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    PMIDs:
    None found


  • Interaction Score: 0.61

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name CNS-5161
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name V3381
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Dimebon
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name dexanabinol, HU-211
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20084518


    Sources:
    PharmGKB

    • Version: 101_38

    Alternate Names:
    GRIN3A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    GRIN3A Gene Symbol
    Q8TCU5 Uniprot Accession
    116443 Entrez Gene Id

    Gene Info:
    Transmembrane Helix Count 4
    Target Subclass Channels
    Target Main Class Receptors

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GRIN3A Display Id
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3A PRECURSOR (N-METHYL-D-ASPARTATE RECEPTOR SUBTYPE NR3A) (NMDAR-L). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8TCU5] Description
    ENSG00000198785 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    GRIN3A Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3A Uniprot Protein Name
    NMD3A_HUMAN Uniprot Id
    ENSG00000198785 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001320

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    16767 HUGO Gene ID
    16767 HUGO Gene Symbol
    glutamate ionotropic receptor NMDA type subunit 3A HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 18-August-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000198785 Gene Symbol
    GRIN3A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    KIAA1973 GENE_SYMBOL
    GRIN3A GENE_SYMBOL
    Glutamate receptor ionotropic, NMDA 3A UNIPROT

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Glutamate receptor ionotropic, NMDA 3A Gene Name
    Q8TCU5 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: