• Interaction Score: 1.93

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

  • Interaction Score: 0.55

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name CNS-5161
    Novel drug target Established target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    PMIDs:
    None found


  • Interaction Score: 0.55

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor blocker
    Direct Interaction yes
    Trial Name AZD-6765

    PMIDs:
    None found


  • Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes
    Trial Name AM-101

    PMIDs:
    None found


  • Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.48

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand None

    PMIDs:
    None found


  • Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name dimiracetam, NT-11624

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name V3381
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.39

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Details of Interaction GluN2C = GluN2D ≥ GluN2B ≥ GluN2A
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.32

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand None

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand None

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name Dimebon

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Full agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? True
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name dexanabinol, HU-211

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    GRIN2D Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 01-August-2011

    Alternate Names:
    NMDE4_HUMAN Uniprot Id
    2906 Entrez Gene Id
    GRIN2D Gene Symbol

    Gene Info:
    Transmembrane Helix Count 4
    Target Subclass Glutamate
    Target Subclass Ligand_gated_ion_channels

    Publications:

    • Version: January-2014

    Alternate Names:
    GRIN2D Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 4 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2D) (NR2D) (NMDAR2D) (EB11). [SOURCE:UNIPROT/SWISSPROT;ACC:O15399] Description
    GRIN2D Display Id
    ENSG00000105464 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    GRIN2D Uniprot Gene Name
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-4 Uniprot Protein Name
    2906 Entrez Gene Id

    Gene Info:
    Interpro Short Name Iontro_glu_rcpt
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    4588 HUGO Gene ID
    4588 HUGO Gene Symbol
    glutamate ionotropic receptor NMDA type subunit 2D HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105464 Gene Symbol
    GRIN2D Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    NMDAR2D GENE_SYMBOL
    GRIN2D GENE_SYMBOL
    Glutamate receptor ionotropic, NMDA 2D UNIPROT

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Glutamate receptor ionotropic, NMDA 2D Gene Name
    O15399 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: