• Interaction Score: 1.88

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? True
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

  • Interaction Score: 0.94

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.54

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name CNS-5161
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    PMIDs:
    None found


  • Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AM-101
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.54

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name AZD-6765
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    PMIDs:
    None found


  • Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name dimiracetam, NT-11624
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


  • Interaction Score: 0.47

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name V3381
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Score: 0.38

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Details of Interaction GluN2C = GluN2D &ge; GluN2B &ge; GluN2A

    PMIDs:
    None found


  • Interaction Score: 0.31

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured <i>vs.</i> exogenously expressed zeta1/epsilon3 (<i>GRIN1/GRIN2C</i>) subunits, at pH 6.9
    Specific Action of the Ligand None
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Dimebon
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.27

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

    PMIDs:
    None found


  • Interaction Score: 0.27

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


  • Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Binding Site for Interaction glutamate site
    Specific Action of the Ligand Full agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    None found


  • Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    GRIN2C Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    Q14957 Uniprot Accession
    NMDE3_HUMAN Uniprot Id
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-3 Uniprot Protein Name

    Gene Info:
    Interpro Acc IPR001320
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    GRIN2C Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1.3

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    GRIN2C Display Id
    ENSG00000161509 Ensembl Gene Id
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 3 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2C) (NR2C) (NMDAR2C). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14957] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    4587 HUGO Gene ID
    4587 HUGO Gene Symbol
    glutamate ionotropic receptor NMDA type subunit 2C HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Ionotropic glutamate receptors
    GuideToPharmacology Gene Category ID 75

    Gene Categories:
    ION CHANNEL

    Publications:

    • Version: 14-September-2017
    • Version: chembl_23

    Alternate Names:
    NMDAR2C GENE_SYMBOL
    GRIN2C GENE_SYMBOL
    Glutamate receptor ionotropic, NMDA 2C UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000161509 Gene Symbol
    GRIN2C Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Glutamate receptor ionotropic, NMDA 2C Gene Name
    Q14957 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: