DGIdb - GPX1 Gene Record

GPX1 2876 Druggable Genome

Alternate Names:

2876
GLUTATHIONE PEROXIDASE 1
GPX1
GPXD
GSHPX1
138320
4553
ENSG00000233276
OTTHUMG00000156837
ENSG00000197582
GLUTATHIONE PEROXIDASE 1 (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P07203]
BE0000816
P07203
GPX1_HUMAN
BE0002287
Q6NSD4

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Interpro Short Name	Glutathione_peroxidase
Interpro Name	Glutathione peroxidase
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000889
Gene Biotype	POLYMORPHIC_PSEUDOGENE

(4 More Sources)

Gene Categories: Category Details

PROTEASE INHIBITOR
DRUGGABLE GENOME

Publications:

Destro-Bisol et al., 1989, Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in central western Africa: a tentative hypothesis on the interaction between GPX12 and Hb beta S allelic products., Am. J. Phys. Anthropol.
Du et al., 2007, N-Acetyltransferase Mpr1 confers ethanol tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species., Appl. Microbiol. Biotechnol.
Walshe et al., 2007, Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation., Cancer Res.
Liddell et al., 2006, Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity., J. Neurosci. Res.
Sheridan et al., 2007, Decreased selenoprotein expression alters the immune response during influenza virus infection in mice., J. Nutr.
Chattopadhyay et al., 2007, Differential expression profiles of antioxidant enzymes and glutathione redox status in hyperthyroid rats: a temporal analysis., Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Ursini et al., 2005, Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples., Int. J. Androl.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Sordillo et al., 2007, Shifts in thioredoxin reductase activity and oxidant status in mononuclear cells obtained from transition dairy cattle., J. Dairy Sci.
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

GLUTATHIONE GPX1

Interaction Score: 5.34

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
2742004 17387467 17510403 16721761 17513408 17561443 15679624 17139284 17016423 17297093

Sources:
DrugBank
CANNABIDIOL GPX1

Interaction Score: 0.88

Interaction Types & Directionality:

stimulator (activating)

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank
NABIXIMOLS GPX1

Interaction Score: 0.86

Interaction Types & Directionality:

stimulator (activating)

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank

Ensembl: ENSG00000233276
- Version: 101_38
Alternate Names:

GPX1 Ensembl Gene Name

Gene Info:

Gene Biotype POLYMORPHIC_PSEUDOGENE

Publications:
HopkinsGroom: P07203
- Version: 11-September-2012
Alternate Names:

GPX1_HUMAN Uniprot Id

GPX1 Uniprot Gene Name

ENSG00000233276 Ensembl Gene Id

Gene Info:

Interpro Type Family

Interpro Short Name Glutathione_peroxidase

Interpro Name Glutathione peroxidase

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000197582

Version: 26-July-2011

Alternate Names:

GPX1 Display Id

GLUTATHIONE PEROXIDASE 1 (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P07203] Description

ENSG00000197582 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

DrugBank: BE0002287

Version: 5.1.7

Alternate Names:

GPX1 DrugBank Gene Name

Q6NSD4 UniProt Accession

2876 Entrez Gene Id

Gene Info:

Publications:

Du et al., 2007, N-Acetyltransferase Mpr1 confers ethanol tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species., Appl. Microbiol. Biotechnol.

Walshe et al., 2007, Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation., Cancer Res.

Sheridan et al., 2007, Decreased selenoprotein expression alters the immune response during influenza virus infection in mice., J. Nutr.

DrugBank: BE0000816

Version: 5.1.7

Alternate Names:

GPX1 DrugBank Gene Name

P07203 UniProt Accession

2876 Entrez Gene Id

Gene Info:

Publications:

Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

Destro-Bisol et al., 1989, Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in central western Africa: a tentative hypothesis on the interaction between GPX12 and Hb beta S allelic products., Am. J. Phys. Anthropol.

Liddell et al., 2006, Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity., J. Neurosci. Res.

NCI: GPX1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Agrawal et al., 2006, Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis., Gene Ther.
HingoraniCasas: ENSG00000233276
- Version: 31-May-2017
Alternate Names:

ENSG00000233276 Gene Symbol

GPX1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: GPX1
- Version: 27-Jun-2013
Alternate Names:

2876 Gene ID

GPXD dGene Synonym

GSHPX1 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE INHIBITOR

Publications:

GPX1_HUMAN	Uniprot Id
GPX1	Uniprot Gene Name
ENSG00000233276	Ensembl Gene Id

GPX1	Display Id
GLUTATHIONE PEROXIDASE 1 (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P07203]	Description
ENSG00000197582	Ensembl Gene Id

GPX1	DrugBank Gene Name
Q6NSD4	UniProt Accession
2876	Entrez Gene Id

2876	Gene ID
GPXD	dGene Synonym
GSHPX1	dGene Synonym

GPX1 Gene Record

GPX1 2876 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

GLUTATHIONE GPX1

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 2742004 17387467 17510403 16721761 17513408 17561443 15679624 17139284 17016423 17297093

Sources: DrugBank

CANNABIDIOL GPX1

Interaction Types & Directionality: stimulator (activating)

Interaction Info:

PMIDs: 26264914

Sources: DrugBank

NABIXIMOLS GPX1

Interaction Types & Directionality: stimulator (activating)

Interaction Info:

PMIDs: 26264914

Sources: DrugBank

Ensembl: ENSG00000233276

Alternate Names: GPX1 Ensembl Gene Name

Gene Info: Gene Biotype POLYMORPHIC_PSEUDOGENE

Publications:

HopkinsGroom: P07203

Alternate Names: GPX1_HUMAN Uniprot Id GPX1 Uniprot Gene Name ENSG00000233276 Ensembl Gene Id

Gene Info: Interpro Type Family Interpro Short Name Glutathione_peroxidase Interpro Name Glutathione peroxidase

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000197582

Alternate Names: GPX1 Display Id GLUTATHIONE PEROXIDASE 1 (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P07203] Description ENSG00000197582 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

DrugBank: BE0002287

Alternate Names: GPX1 DrugBank Gene Name Q6NSD4 UniProt Accession 2876 Entrez Gene Id

Gene Info:

DrugBank: BE0000816

Alternate Names: GPX1 DrugBank Gene Name P07203 UniProt Accession 2876 Entrez Gene Id

Gene Info:

NCI: GPX1

Alternate Names:

Gene Info:

Publications: Agrawal et al., 2006, Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis., Gene Ther.

HingoraniCasas: ENSG00000233276

Alternate Names: ENSG00000233276 Gene Symbol GPX1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

dGene: GPX1

Alternate Names: 2876 Gene ID GPXD dGene Synonym GSHPX1 dGene Synonym

Gene Info:

Gene Categories: PROTEASE INHIBITOR

Publications:

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
2742004 17387467 17510403 16721761 17513408 17561443 15679624 17139284 17016423 17297093

Sources:
DrugBank

Interaction Types & Directionality:

stimulator (activating)

PMIDs:
26264914

Sources:
DrugBank

Interaction Types & Directionality:

stimulator (activating)

PMIDs:
26264914

Sources:
DrugBank

Alternate Names:

GPX1 Ensembl Gene Name

Gene Info:

Gene Biotype POLYMORPHIC_PSEUDOGENE

Alternate Names:

GPX1_HUMAN Uniprot Id

GPX1 Uniprot Gene Name

ENSG00000233276 Ensembl Gene Id

Gene Info:

Interpro Type Family

Interpro Short Name Glutathione_peroxidase

Interpro Name Glutathione peroxidase

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GPX1 Display Id

GLUTATHIONE PEROXIDASE 1 (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P07203] Description

ENSG00000197582 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GPX1 DrugBank Gene Name

Q6NSD4 UniProt Accession

2876 Entrez Gene Id

Alternate Names:

GPX1 DrugBank Gene Name

P07203 UniProt Accession

2876 Entrez Gene Id

Publications:

Agrawal et al., 2006, Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis., Gene Ther.

Alternate Names:

ENSG00000233276 Gene Symbol

GPX1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

2876 Gene ID

GPXD dGene Synonym

GSHPX1 dGene Synonym

Gene Categories:

PROTEASE INHIBITOR