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GPX1 Gene Record

  • Summary
  • Interactions
  • Claims
  • GPX1 2876 Druggable Genome

    Alternate Names:

    2876
    GLUTATHIONE PEROXIDASE 1
    GPX1
    GPXD
    GSHPX1
    138320
    4553
    ENSG00000233276
    OTTHUMG00000156837
    ENSG00000197582
    GLUTATHIONE PEROXIDASE 1 (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P07203]
    BE0000816
    P07203
    GPX1_HUMAN
    BE0002287
    Q6NSD4

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Short Name Glutathione_peroxidase
    Interpro Name Glutathione peroxidase
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000889
    Gene Biotype POLYMORPHIC_PSEUDOGENE
    (4 More Sources)

    Gene Categories: Category Details

    PROTEASE INHIBITOR
    DRUGGABLE GENOME

    Publications:

    Destro-Bisol et al., 1989, Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in central western Africa: a tentative hypothesis on the interaction between GPX1*2 and Hb beta *S allelic products., Am. J. Phys. Anthropol.
    Du et al., 2007, N-Acetyltransferase Mpr1 confers ethanol tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species., Appl. Microbiol. Biotechnol.
    Walshe et al., 2007, Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation., Cancer Res.
    Liddell et al., 2006, Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity., J. Neurosci. Res.
    Sheridan et al., 2007, Decreased selenoprotein expression alters the immune response during influenza virus infection in mice., J. Nutr.
    Chattopadhyay et al., 2007, Differential expression profiles of antioxidant enzymes and glutathione redox status in hyperthyroid rats: a temporal analysis., Comp. Biochem. Physiol. C Toxicol. Pharmacol.
    Ursini et al., 2005, Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples., Int. J. Androl.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Sordillo et al., 2007, Shifts in thioredoxin reductase activity and oxidant status in mononuclear cells obtained from transition dairy cattle., J. Dairy Sci.
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
  • GLUTATHIONE   GPX1

    Interaction Score: 5.34

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    2742004 17387467 17510403 16721761 17513408 17561443 15679624 17139284 17016423 17297093


    Sources:
    DrugBank

  • CANNABIDIOL   GPX1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • NABIXIMOLS   GPX1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • Ensembl: ENSG00000233276

    • Version: 101_38

    Alternate Names:
    GPX1 Ensembl Gene Name

    Gene Info:
    Gene Biotype POLYMORPHIC_PSEUDOGENE

    Publications:

  • HopkinsGroom: P07203

    • Version: 11-September-2012

    Alternate Names:
    GPX1_HUMAN Uniprot Id
    GPX1 Uniprot Gene Name
    ENSG00000233276 Ensembl Gene Id

    Gene Info:
    Interpro Type Family
    Interpro Short Name Glutathione_peroxidase
    Interpro Name Glutathione peroxidase

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000197582

    • Version: 26-July-2011

    Alternate Names:
    GPX1 Display Id
    GLUTATHIONE PEROXIDASE 1 (EC 1.11.1.9) (GSHPX-1) (CELLULAR GLUTATHIONE PEROXIDASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P07203] Description
    ENSG00000197582 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DrugBank: BE0002287

    • Version: 5.1.7

    Alternate Names:
    GPX1 DrugBank Gene Name
    Q6NSD4 UniProt Accession
    2876 Entrez Gene Id

    Gene Info:

    Publications:
    Du et al., 2007, N-Acetyltransferase Mpr1 confers ethanol tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species., Appl. Microbiol. Biotechnol.
    Walshe et al., 2007, Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation., Cancer Res.
    Sheridan et al., 2007, Decreased selenoprotein expression alters the immune response during influenza virus infection in mice., J. Nutr.

  • DrugBank: BE0000816

    • Version: 5.1.7

    Alternate Names:
    GPX1 DrugBank Gene Name
    P07203 UniProt Accession
    2876 Entrez Gene Id

    Gene Info:

    Publications:
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Destro-Bisol et al., 1989, Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in central western Africa: a tentative hypothesis on the interaction between GPX1*2 and Hb beta *S allelic products., Am. J. Phys. Anthropol.
    Liddell et al., 2006, Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity., J. Neurosci. Res.

  • NCI: GPX1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Agrawal et al., 2006, Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis., Gene Ther.

  • HingoraniCasas: ENSG00000233276

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000233276 Gene Symbol
    GPX1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: GPX1

    • Version: 27-Jun-2013

    Alternate Names:
    2876 Gene ID
    GPXD dGene Synonym
    GSHPX1 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE INHIBITOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21