DGIdb - GPR35 Gene Record

GPR35 2859 Druggable Genome

Alternate Names:

2859
G PROTEIN-COUPLED RECEPTOR 35
GPR35
602646
4492
ENSG00000178623
OTTHUMG00000133356
GPR35_HUMAN
Q9HC97
PROBABLE G-PROTEIN COUPLED RECEPTOR 35. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9HC97]
G-PROTEIN COUPLED RECEPTOR 35
102
<i>GPR35</i>
-
NP_005292
NM_005301
BE0005562

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Name	GPCR, rhodopsin-like, 7TM
Interpro Acc	IPR000276
Uniprot Evidence	2: Evidence at transcript level
Interpro Type	Family
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Class A Orphans
GuideToPharmacology Gene Category ID	16

(5 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Deng H et al., 2012, Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists., Bioorg Med Chem Lett
Deng H et al., 2011, Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists., J Med Chem
Yang et al., 2012, GPR35 is a target of the loop diuretic drugs bumetanide and furosemide., Pharmacology
Divorty N et al., 2018, The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice., Am J Hypertens
Divorty N et al., 2015, G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease., Front Pharmacol
Zhao P et al., 2010, Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity., Mol Pharmacol

PYRANTEL GPR35

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20826425

Sources:
DrugBank
CHEMBL107513 GPR35

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1708510 GPR35

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21950657

Sources:
DTC
LODOXAMIDE GPR35

Interaction Score: 3.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology
TOLCAPONE GPR35

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRANSTORINE GPR35

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20826425

Sources:
DrugBank
FUROSEMIDE GPR35

Interaction Score: 1.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
22236570 29860395 25805994

Sources:
DrugBank GuideToPharmacology
CHEMBL394883 GPR35

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZAPRINAST GPR35

Interaction Score: 1.0

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
22572579

Sources:
DTC GuideToPharmacology
2,4-DINITROPHENOL GPR35

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NIFLUMIC ACID GPR35

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1256291 GPR35

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUMETANIDE GPR35

Interaction Score: 0.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
BAICALEIN GPR35

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LUTEOLIN GPR35

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MYRICETIN GPR35

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN GPR35

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000178623
- Version: 101_38
Alternate Names:

GPR35 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q9HC97
- Version: 11-September-2012
Alternate Names:

G-PROTEIN COUPLED RECEPTOR 35 Uniprot Protein Name

GPR35 Uniprot Gene Name

ENSG00000178623 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Short Name 7TM_GPCR_Rhodpsn

Interpro Name GPCR, rhodopsin-like, 7TM

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000178623
- Version: 26-July-2011
Alternate Names:

GPR35 Display Id

PROBABLE G-PROTEIN COUPLED RECEPTOR 35. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9HC97] Description

ENSG00000178623 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 2859
- Version: 29-September-2020
Alternate Names:

4492 HUGO Gene ID

4492 HUGO Gene Symbol

G protein-coupled receptor 35 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Class A Orphans

GuideToPharmacology Gene Category ID 16

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

DrugBank: BE0005562

Version: 5.1.7

Alternate Names:

GPR35 DrugBank Gene Name

Q9HC97 UniProt Accession

2859 Entrez Gene Id

Gene Info:

Publications:

Yang et al., 2012, GPR35 is a target of the loop diuretic drugs bumetanide and furosemide., Pharmacology

Divorty N et al., 2018, The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice., Am J Hypertens

Divorty N et al., 2015, G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease., Front Pharmacol

DTC: GPR35

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Deng H et al., 2011, Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists., J Med Chem

Deng H et al., 2012, Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000178623
- Version: 31-May-2017
Alternate Names:

ENSG00000178623 Gene Symbol

GPR35 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: GPR35
- Version: 27-Jun-2013
Alternate Names:

2859 Gene ID

- dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
GO: GPR35
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Agonist

G-PROTEIN COUPLED RECEPTOR 35	Uniprot Protein Name
GPR35	Uniprot Gene Name
ENSG00000178623	Ensembl Gene Id

GPR35	Display Id
PROBABLE G-PROTEIN COUPLED RECEPTOR 35. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9HC97]	Description
ENSG00000178623	Ensembl Gene Id

4492	HUGO Gene ID
4492	HUGO Gene Symbol
G protein-coupled receptor 35	HUGO Gene Name

GPR35	DrugBank Gene Name
Q9HC97	UniProt Accession
2859	Entrez Gene Id

GPR35 Gene Record

GPR35 2859 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20826425

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21950657

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Agonist

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20826425

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False

PMIDs: 22236570 29860395 25805994

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False

PMIDs: 22572579

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Ensembl: ENSG00000178623

Alternate Names: GPR35 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q9HC97

Alternate Names: G-PROTEIN COUPLED RECEPTOR 35 Uniprot Protein Name GPR35 Uniprot Gene Name ENSG00000178623 Ensembl Gene Id

Interaction Types & Directionality:

n/a

PMIDs:
20826425

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21950657

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20826425

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
22236570 29860395 25805994

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
22572579

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

GPR35 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

G-PROTEIN COUPLED RECEPTOR 35 Uniprot Protein Name

GPR35 Uniprot Gene Name

ENSG00000178623 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Short Name 7TM_GPCR_Rhodpsn

Interpro Name GPCR, rhodopsin-like, 7TM

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

GPR35 Display Id

PROBABLE G-PROTEIN COUPLED RECEPTOR 35. [SOURCE:UNIPROT/SWISSPROT;ACC:Q9HC97] Description

ENSG00000178623 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

4492 HUGO Gene ID

4492 HUGO Gene Symbol

G protein-coupled receptor 35 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Class A Orphans

GuideToPharmacology Gene Category ID 16

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

GPR35 DrugBank Gene Name

Q9HC97 UniProt Accession

2859 Entrez Gene Id

Alternate Names:

ENSG00000178623 Gene Symbol

GPR35 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

2859 Gene ID

- dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR