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GPR12 Gene Record

  • Summary
  • Interactions
  • Claims
  • GPR12 2835 Druggable Genome

    Alternate Names:

    2835
    G PROTEIN-COUPLED RECEPTOR 12
    GPR12
    GPCR12
    GPCR21
    PPP1R84
    600752
    4466
    ENSG00000132975
    OTTHUMG00000016620
    P47775
    GPR12_HUMAN
    G-PROTEIN COUPLED RECEPTOR 12
    PROBABLE G-PROTEIN COUPLED RECEPTOR 12. [SOURCE:UNIPROT/SWISSPROT;ACC:P47775]
    <i>GPR12</i>
    86
    NM_005288
    NP_005279
    BE0009153

    Gene Info:

    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Class A Orphans
    GuideToPharmacology Gene Category ID 16
    (7 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Du L et al., 2008, Unusual C25 steroid isomers with bicyclo[4.4.1]A/B rings from a volcano ash-derived fungus Penicillium citrinum., J Nat Prod
    Brown KJ et al., 2017, Cannabidiol, a novel inverse agonist for GPR12., Biochem Biophys Res Commun
    Laprairie RB et al., 2015, Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor., Br J Pharmacol
  • NEOCYCLOCITRINOL C   GPR12

    Interaction Score: 18.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18656987


    Sources:
    DTC

  • CHEMBL496266   GPR12

    Interaction Score: 18.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18656987


    Sources:
    DTC

  • CYCLOCITRINOL   GPR12

    Interaction Score: 18.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18656987


    Sources:
    DTC

  • NEOCYCLOCITRINOL B   GPR12

    Interaction Score: 18.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18656987


    Sources:
    DTC

  • CANNABIDIOL   GPR12

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:

    PMIDs:
    28888984


    Sources:
    DrugBank

  • NABIXIMOLS   GPR12

    Interaction Score: 0.43

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:

    PMIDs:
    26218440


    Sources:
    DrugBank

  • Ensembl: ENSG00000132975

    • Version: 101_38

    Alternate Names:
    GPR12 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000132975

    • Version: 26-July-2011

    Alternate Names:
    GPR12 Display Id
    ENSG00000132975 Ensembl Gene Id
    PROBABLE G-PROTEIN COUPLED RECEPTOR 12. [SOURCE:UNIPROT/SWISSPROT;ACC:P47775] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P47775

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000132975 Ensembl Gene Id
    G-PROTEIN COUPLED RECEPTOR 12 Uniprot Protein Name
    GPR12_HUMAN Uniprot Id

    Gene Info:
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000276

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 2835

    • Version: 29-September-2020

    Alternate Names:
    4466 HUGO Gene ID
    4466 HUGO Gene Symbol
    G protein-coupled receptor 12 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Class A Orphans
    GuideToPharmacology Gene Category ID 16

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • DrugBank: BE0009153

    • Version: 5.1.7

    Alternate Names:
    GPR12 DrugBank Gene Name
    P47775 UniProt Accession
    2835 Entrez Gene Id

    Gene Info:

    Publications:
    Brown KJ et al., 2017, Cannabidiol, a novel inverse agonist for GPR12., Biochem Biophys Res Commun
    Laprairie RB et al., 2015, Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor., Br J Pharmacol

  • DTC: GPR12

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Du L et al., 2008, Unusual C25 steroid isomers with bicyclo[4.4.1]A/B rings from a volcano ash-derived fungus Penicillium citrinum., J Nat Prod

  • HingoraniCasas: ENSG00000132975

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000132975 Gene Symbol
    GPR12 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • IDG: GPR12

    • Version: 15-July-2019

    Alternate Names:
    GPR12 Gene Symbol

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • Pharos: GPR12

    • Version: 03-September-2020

    Alternate Names:
    G-protein coupled receptor 12 Gene Name
    P47775 UniProt ID

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: GPR12

    • Version: 27-Jun-2013

    Alternate Names:
    2835 Gene ID
    GPCR12 dGene Synonym
    GPCR21 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • GO: GPR12

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21