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GNRH1 Gene Record

  • Summary
  • Interactions
  • Claims
  • GNRH1 2796 Druggable Genome

    Alternate Names:

    2796
    GONADOTROPIN RELEASING HORMONE 1
    GNRH1
    GNRH
    GRH
    LHRH
    LNRH
    152760
    4419
    ENSG00000147437
    OTTHUMG00000163852
    LEUTINIZING-HORMONE-RELEASING HORMONE
    P01148
    T18950

    Gene Info:

    Target Class Ligand
    Target Subclass Ligand
    Target Subclass GnRH
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    HORMONE ACTIVITY
    DRUGGABLE GENOME

    Publications:

    Dharap et al., 2005, Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide., Proc. Natl. Acad. Sci. U.S.A.
    Hunter et al., 1989, Luteinizing hormone responses to luteinizing hormone releasing hormone (LHRH) in acute mania and the effects of lithium on LHRH and thyrotrophin releasing hormone tests in volunteers., Psychol Med
    Kumar et al., 1994, Effect of chronic DDC treatment on LHRH and substance P amidation processes in the rat., Brain Res. Bull.
    Johnson et al., 1984, Effects of aminoglutethimide on luteinizing hormone and steroid secretion, and ovulation in the hen, Gallus domesticus., Endocrinology
    Merchenthaler et al., 1980, Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats., Cell Tissue Res.
    Tena-Sempere et al., 2004, Mechanisms for altered reproductive function in female rats following neonatal administration of raloxifene., Eur. J. Endocrinol.
    Lasdun et al., 1989, Inhibition of endopeptidase 24.15 slows the in vivo degradation of luteinizing hormone-releasing hormone., J. Pharmacol. Exp. Ther.
  • CHEMBL208519   GNRH1

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ZALCITABINE   GNRH1

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7507399


    Sources:
    NCI

  • AMINOGLUTETHIMIDE   GNRH1

    Interaction Score: 1.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6373241


    Sources:
    NCI

  • DITIOCARB   GNRH1

    Interaction Score: 1.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7507399


    Sources:
    NCI

  • DAPSONE   GNRH1

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16123131


    Sources:
    NCI

  • GOSERELIN   GNRH1

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CAPTOPRIL   GNRH1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2681686


    Sources:
    NCI

  • LEUPROLIDE   GNRH1

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RESERPINE   GNRH1

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6996825


    Sources:
    NCI

  • RALOXIFENE   GNRH1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15012627


    Sources:
    NCI

  • LITHIUM   GNRH1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2498919


    Sources:
    NCI

  • Ensembl: ENSG00000147437

    • Version: 101_38

    Alternate Names:
    GNRH1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P01148

    • Version: January-2014

    Alternate Names:
    GNRH1 Gene Symbol

    Gene Info:
    Target Class Ligand
    Target Subclass Ligand
    Target Subclass GnRH

    Publications:

  • NCI: GNRH1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Dharap et al., 2005, Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide., Proc. Natl. Acad. Sci. U.S.A.
    Kumar et al., 1994, Effect of chronic DDC treatment on LHRH and substance P amidation processes in the rat., Brain Res. Bull.
    Tena-Sempere et al., 2004, Mechanisms for altered reproductive function in female rats following neonatal administration of raloxifene., Eur. J. Endocrinol.

  • HingoraniCasas: ENSG00000147437

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000147437 Gene Symbol
    GNRH1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: GNRH1

    • Version: 01-February-2022

    Alternate Names:
    GNRH GO Gene Synonym
    GRH GO Gene Synonym
    LHRH GO Gene Synonym

    Gene Info:

    Gene Categories:
    HORMONE ACTIVITY

    Publications:

  • TTD: Leutinizing-hormone-releasing hormone

    • Version: 2020.06.01

    Alternate Names:
    GNRH1 TTD Gene Abbreviation
    T18950 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21