• Interaction Score: 2.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy AEB071 + CGM097
    Indication/Tumor Type uveal melanoma
    Response Type predicted – sensitive

    PMIDs:
    27507190


    Sources:
    JAX-CKB

  • Interaction Score: 1.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Clinical Status early trials
    Pathway activation
    Variant Effect gain-of-function

  • Interaction Score: 1.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type uveal melanoma
    Response Type sensitive
    Approval Status Preclinical - Cell culture

    PMIDs:
    22515704


    Sources:
    JAX-CKB

  • Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy MEK162 + AEB071
    Indication/Tumor Type uveal melanoma
    Response Type sensitive


    Sources:
    JAX-CKB

  • Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28103611


    Sources:
    CIViC

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy AEB071 + CGM097
    Approval Status Preclinical - Pdx & cell culture
    Response Type predicted – sensitive


    Sources:
    JAX-CKB

  • Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy AEB071 + Everolimus
    Indication/Tumor Type uveal melanoma
    Response Type predicted – sensitive

    PMIDs:
    27507190


    Sources:
    JAX-CKB

  • Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type uveal melanoma
    Response Type sensitive
    Approval Status Preclinical - Cell culture

    PMIDs:
    22733540


    Sources:
    JAX-CKB

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family HDAC inhibitor
    Alteration GNA11:Q209L,Q209P

    PMIDs:
    None found


    Sources:
    CGI