-
GLRA1 2741 Druggable Genome
Alternate Names:
2741 GLYCINE RECEPTOR ALPHA 1 GLRA1 HKPX1 STHE 138491 4326 ENSG00000145888 OTTHUMG00000130121 GLYCINE RECEPTOR ALPHA-1 CHAIN PRECURSOR (GLYCINE RECEPTOR 48 KDA SUBUNIT) (STRYCHNINE BINDING SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P23415] BE0000433 P23415 GLRA1_HUMAN Glycine receptor strychnine-binding subunit Glycine receptor 48 kDa subunit Glycine receptor subunit alpha-1 BE0004857 glycine receptor α1 subunit Strychnine-binding glycine receptor T50269 NP_000162 NM_000171 423 BE0009666 Gene Info:
Human Readable Name DRUGGABLE GENOME Target Main Class Receptors Transmembrane Helix Count 3 Target Subclass Channels Target Subclass Ligand_gated_ion_channels Target Subclass cys-loop Target Class Receptors Target Subclass TC:1.A.9.3.1 Uniprot Status Swiss-Prot Interpro Type Family Human Readable Name ION CHANNEL Interpro Short Name Neur_channel Interpro Acc IPR006202 Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR006201 Interpro Type Domain Interpro Short Name Neur_chan_lig-bd Interpro Name Neurotransmitter-gated ion-channel ligand-binding Interpro Name Neurotransmitter-gated ion-channel Gene Biotype PROTEIN_CODING GuideToPharmacology Gene Category Name Glycine receptors GuideToPharmacology Gene Category ID 73 Gene Categories: Category Details
ION CHANNEL EXTERNAL SIDE OF PLASMA MEMBRANE DRUGGABLE GENOME Publications:
-
Interaction Score: 3.44
-
Interaction Score: 1.29
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Details of Interaction weak inhibition Endogenous Drug? False -
Interaction Score: 1.15
-
Interaction Score: 0.86
-
Interaction Score: 0.65
-
Interaction Score: 0.57
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.43
Interaction Types & Directionality:
allosteric modulator Interaction Info:
Specific Action of the Ligand Potentiation Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.43
Interaction Types & Directionality:
blocker (inhibitory) Interaction Info:
Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False -
Interaction Types & Directionality:
blocker (inhibitory) Interaction Info:
Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.4
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Trial Name - Novel drug target Established target Mechanism of Interaction Glycine receptor (alpha-1/beta) positive modulator -
Interaction Score: 0.37
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Novel drug target Established target Trial Name - Direct Interaction yes -
Interaction Types & Directionality:
agonist (activating) potentiator Interaction Info:
Mechanism of Interaction Glycine receptor (alpha-1/beta) positive modulator Direct Interaction yes Trial Name - -
Interaction Score: 0.35
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Trial Name - Novel drug target Established target Mechanism of Interaction Glycine receptor (alpha-1/beta) positive modulator -
Interaction Score: 0.33
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Mechanism of Interaction Glycine receptor (alpha-1/beta) agonist Direct Interaction yes -
Interaction Score: 0.22
Interaction Types & Directionality:
blocker (inhibitory) antagonist (inhibitory) Interaction Info:
Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand None -
Interaction Types & Directionality:
allosteric modulator Interaction Info:
Mechanism of Interaction Glycine receptor (alpha-1/beta) positive modulator Direct Interaction yes -
Interaction Score: 0.19
-
Interaction Score: 0.17
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.17
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.12
-
Interaction Score: 0.11
Interaction Types & Directionality:
allosteric modulator Interaction Info:
Specific Action of the Ligand Potentiation Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.08
-
Interaction Score: 0.04
-
Interaction Score: 0.04
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.03
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.02
-
- Version: 101_38
Alternate Names:
GLRA1 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
-
- Version: 26-July-2011
Alternate Names:
GLRA1 Display Id GLYCINE RECEPTOR ALPHA-1 CHAIN PRECURSOR (GLYCINE RECEPTOR 48 KDA SUBUNIT) (STRYCHNINE BINDING SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P23415] Description ENSG00000145888 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
-
Alternate Names:
GLRA1 Gene Symbol P23415 Uniprot Accession 2741 Entrez Gene Id Gene Info:
Transmembrane Helix Count 3 Target Subclass Channels Target Subclass Ligand_gated_ion_channels Publications:
-
- Version: January-2014
Alternate Names:
GLRA1 Gene Symbol Gene Info:
Target Class Receptors Target Subclass TC:1.A.9.3.1 Publications:
-
- Version: 11-September-2012
Alternate Names:
GLRA1_HUMAN Uniprot Id ENSG00000145888 Ensembl Gene Id P23415 Uniprot Accession Gene Info:
Uniprot Status Swiss-Prot Interpro Type Family Human Readable Name ION CHANNEL Gene Categories:
ION CHANNEL, DRUGGABLE GENOME Publications:
-
- Version: 29-September-2020
Alternate Names:
4326 HUGO Gene ID 4326 HUGO Gene Symbol glycine receptor alpha 1 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Glycine receptors GuideToPharmacology Gene Category ID 73 Gene Categories:
ION CHANNEL Publications:
-
Alternate Names:
GLRA1 DrugBank Gene Name P23415 UniProt Accession 2741 Entrez Gene Id Gene Info:
Publications:
-
Alternate Names:
GLRA1 DrugBank Gene Name P23415 UniProt Accession 2741 Entrez Gene Id Gene Info:
-
Alternate Names:
GLRA1 DrugBank Gene Name P23415 UniProt Accession 2741 Entrez Gene Id Gene Info:
Publications:
-
Alternate Names:
Gene Info:
-
- Version: chembl_23
Alternate Names:
GLRA1 GENE_SYMBOL Glycine receptor subunit alpha-1 UNIPROT Glycine receptor 48 kDa subunit UNIPROT Gene Info:
Publications:
-
- Version: 31-May-2017
Alternate Names:
ENSG00000145888 Gene Symbol GLRA1 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
-
Alternate Names:
Glycine receptor subunit alpha-1 Gene Name P23415 UniProt ID Gene Info:
Gene Categories:
ION CHANNEL Publications:
-
- Version: 2020.06.01
Alternate Names:
GLRA1 TTD Gene Abbreviation T50269 TTD Target ID Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
EXTERNAL SIDE OF PLASMA MEMBRANE Publications: