DGIdb - GLP1R Gene Record

GLP1R 2740 Druggable Genome

Alternate Names:

2740
GLUCAGON LIKE PEPTIDE 1 RECEPTOR
GLP1R
GLP-1
GLP-1-R
GLP-1R
138032
4324
ENSG00000112164
OTTHUMG00000014638
P43220
GLP-1 receptor
glucagon-like peptide 1 receptor
GLP1R_HUMAN
GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR) (GLP-1-R) (GLP-1R). [SOURCE:UNIPROT/SWISSPROT;ACC:P43220]
PA28725
T36075
-

Gene Info:

Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Interpro Name	GPCR, family 2, secretin-like
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Acc	IPR000832
Interpro Short Name	GPCR_2_secretin-like
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Target Subclass	Secretin
Target Subclass	GPCR
Target Main Class	Receptors
Transmembrane Helix Count	7
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Javorský M et al., 2016, A missense variant in GLP1R gene is associated with the glycaemic response to treatment with gliptins., Diabetes Obes Metab
Yu M et al., 2019, GLP1R variant is associated with response to exenatide in overweight Chinese Type 2 diabetes patients., Pharmacogenomics
Briones et al., 2006, Exenatide: a GLP-1 receptor agonist as novel therapy for Type 2 diabetes mellitus., Expert Opin Pharmacother
Diamant et al., 2004, [Analogs of glucagon-like peptide-1 (GLP-1): an old concept as a new treatment of patients with diabetes mellitus type 2]., Ned Tijdschr Geneeskd
Kolterman et al., 2005, Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus., Am J Health Syst Pharm
Wajchenberg, 2007, beta-cell failure in diabetes and preservation by clinical treatment., Endocr. Rev.
Mann et al., 2010, The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4., Br. J. Pharmacol.
Mack et al., 2006, Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures., Int J Obes (Lond)
Degn et al., 2004, Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia., Diabetes
Barnett, 2005, Exenatide., Drugs Today
Hargrove et al., 2007, Biological activity of AC3174, a peptide analog of exendin-4., Regul. Pept.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Lebovitz, Therapeutic options in development for management of diabetes: pharmacologic agents and new technologies., Endocr Pract
Geelhoed-Duijvestijn, 2007, Incretins: a new treatment option for type 2 diabetes?, Neth J Med
Larsen et al., 2008, Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats., Diabetes Obes Metab
Bock et al., 2003, The endocrine pancreas in non-diabetic rats after short-term and long-term treatment with the long-acting GLP-1 derivative NN2211., APMIS
Jensterle M et al., 2015, Genetic variability in GLP-1 receptor is associated with inter-individual differences in weight lowering potential of liraglutide in obese women with PCOS: a pilot study., Eur J Clin Pharmacol
Sanford, 2014, Dulaglutide: first global approval., Drugs
Trujillo et al., 2014, Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes., Ann Pharmacother
Lee YS et al., 2014, Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells., Metabolism
Durante C et al., 2011, XL184 (cabozantinib) for medullary thyroid carcinoma., Expert Opin Investig Drugs
Brandl EJ et al., 2014, Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain., Pharmacogenomics

EXENATIDE GLP1R

Interaction Score: 7.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Trial Name PC-DAC:Exendin-4

PMIDs:
30883264 16722815 15495988 15700891 17353295 20649595 16534527 15331551 16341288 17292977 11752352 16627399 17379930

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
LIRAGLUTIDE GLP1R

Interaction Score: 2.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name NN9924

Novel drug target Established target

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

PMIDs:
18333889 14678021 25991051

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB TTD
SEMAGLUTIDE GLP1R

Interaction Score: 1.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

PMIDs:
24140094 21314233

Sources:
ChemblInteractions TTD
ALBIGLUTIDE GLP1R

Interaction Score: 1.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

Trial Name albiglutide, GSK716155,Syncria

PMIDs:
25136065

Sources:
TdgClinicalTrial ChemblInteractions TTD
DULAGLUTIDE GLP1R

Interaction Score: 1.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

Trial Name LY-2189265

PMIDs:
25367716

Sources:
TdgClinicalTrial ChemblInteractions TTD
TASPOGLUTIDE GLP1R

Interaction Score: 1.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

Trial Name taspoglutide, ITM-077, R1583, BIM-51077

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
LIXISENATIDE GLP1R

Interaction Score: 0.82

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL597244 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1337519 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GLP-1 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL580207 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL589909 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL605708 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL603130 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL576809 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VILDAGLIPTIN GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27160388

Sources:
PharmGKB
CHEMBL548286 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1472891 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1422704 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL581865 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYROXAMINE MALEATE GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL592118 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL602012 GLP1R

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SITAGLIPTIN GLP1R

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27160388

Sources:
PharmGKB
CHEMBL606460 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL582286 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PEGAPAMODUTIDE GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MEPAZINE ACETATE GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL601400 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL585443 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL597251 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZPIPERYLON GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578515 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MOFEBUTAZONE GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL579956 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MAGNOLOL GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL586078 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL585444 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL589670 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1224483 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL588028 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL590686 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL590427 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLANFENUR GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1308346 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1520282 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1270168 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL532412 GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DESIPRAMINE HYDROCHLORIDE GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL603154 GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SAR425899 GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL532452 GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL590919 GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOASPEPTIDE A GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL524376 GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1256746 GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMCINAFIDE GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL587564 GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL586163 GLP1R

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL127579 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGITOXIGENIN GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CORONOPILIN GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPIONYLPROMAZINE HYDROCHLORIDE GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL601351 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578928 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METAPHIT METHANESULFONATE GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL602923 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENBENDAZOLE GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL317115 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL259805 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMORFRUTIN A GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL588683 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1439833 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OXYCARBOXIN GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENCLOMIPHENE GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL591598 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DULOXETINE HYDROCHLORIDE GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL604664 GLP1R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL261693 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1437888 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL260451 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1569494 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL405914 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1549738 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1509103 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL530609 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRAMLINTIDE GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL599100 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
6-AZAURIDINE GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL528791 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL584269 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL589245 GLP1R

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NORTRIPTYLINE HYDROCHLORIDE GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICLABENDAZOLE GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1390716 GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STROPHANTHIDIN GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1543865 GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALBUTEROL GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GERONTOXANTHONE H GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SCOULERINE GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL581152 GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL580340 GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL533082 GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1170485 GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FIDUXOSIN HYDROCHLORIDE GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL580076 GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1420370 GLP1R

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL591834 GLP1R

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL528181 GLP1R

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL581872 GLP1R

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1256697 GLP1R

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIHYDROXANTHOHUMOL GLP1R

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL580727 GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLFORSIN GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MITONAFIDE GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1466186 GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1327172 GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL604321 GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL259615 GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL607309 GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LASALOCID A SODIUM GLP1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAROXETINE HYDROCHLORIDE GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
2-METHOXYESTRADIOL GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL588038 GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL579318 GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOXYQUIN GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
INDOPROFEN GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AURIN GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL600734 GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYRITHIONE GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL591126 GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ANGUSTIBALIN GLP1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PINAFIDE GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL86464 GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL482050 GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL533602 GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KEPONE GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CETYLPYRIDINIUM BROMIDE GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOHEXIMIDE GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL584458 GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL493863 GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HELENALIN GLP1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ASTERRIC ACID GLP1R

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYRONIN Y GLP1R

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENTICLOR GLP1R

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIFLUOPERAZINE GLP1R

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HOMIDIUM BROMIDE GLP1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOZAPINE GLP1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24624910

Sources:
PharmGKB
CLOTRIMAZOLE GLP1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLANZAPINE GLP1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24624910

Sources:
PharmGKB
ETOPOSIDE GLP1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000112164
- Version: 101_38
Alternate Names:

GLP1R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P43220
- Version: 11-September-2012
Alternate Names:

P43220 Uniprot Accession

GLP1R Uniprot Gene Name

ENSG00000112164 Ensembl Gene Id

Gene Info:

Interpro Type Family

Uniprot Evidence 1: Evidence at protein level

Interpro Name GPCR, family 2, secretin-like

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P43220
- Version: January-2014
Alternate Names:

GLP1R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Secretin

Publications:
TEND: P43220
- Version: 01-August-2011
Alternate Names:

GLP1R Gene Symbol

ENSG00000112164 Ensembl Gene Id

P43220 Uniprot Accession

Gene Info:

Target Subclass Secretin

Target Subclass GPCR

Target Main Class Receptors

Publications:
RussLampel: ENSG00000112164
- Version: 26-July-2011
Alternate Names:

GLP1R Display Id

GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR) (GLP-1-R) (GLP-1R). [SOURCE:UNIPROT/SWISSPROT;ACC:P43220] Description

ENSG00000112164 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: GLP1R

Version: 18-August-2020

Alternate Names:

PA28725 PharmGKB ID

Gene Info:

Publications:

Javorský M et al., 2016, A missense variant in GLP1R gene is associated with the glycaemic response to treatment with gliptins., Diabetes Obes Metab

Brandl EJ et al., 2014, Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain., Pharmacogenomics

Yu M et al., 2019, GLP1R variant is associated with response to exenatide in overweight Chinese Type 2 diabetes patients., Pharmacogenomics

TTD: Glucagon-like peptide 1 receptor

Version: 2020.06.01

Alternate Names:

GLP1R TTD Gene Abbreviation

T36075 TTD Target ID

Gene Info:

Publications:

Chia CW et al., 2009, Role and development of GLP-1 receptor agonists in the management of diabetes., Diabetes Metab Syndr Obes

Willard FS et al., 2012, Small molecule drug discovery at the glucagon-like peptide-1 receptor., Exp Diabetes Res

Rader C, 2014, Chemically programmed antibodies., Trends Biotechnol

HingoraniCasas: ENSG00000112164
- Version: 31-May-2017
Alternate Names:

ENSG00000112164 Gene Symbol

GLP1R Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: GLP1R
- Version: chembl_23
Alternate Names:

GLP1R GENE_SYMBOL

Glucagon-like peptide 1 receptor UNIPROT

GLP-1 receptor UNIPROT

Gene Info:

Publications:
dGene: GLP1R
- Version: 27-Jun-2013
Alternate Names:

2740 Gene ID

- dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
DTC: GLP1R
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Glucagon-like peptide 1 receptor agonist
Trial Name	PC-DAC:Exendin-4

Trial Name	NN9924
Novel drug target	Established target
Mechanism of Interaction	Glucagon-like peptide 1 receptor agonist

P43220	Uniprot Accession
GLP1R	Uniprot Gene Name
ENSG00000112164	Ensembl Gene Id

GLP1R	Gene Symbol
ENSG00000112164	Ensembl Gene Id
P43220	Uniprot Accession

GLP1R	Display Id
GLUCAGON-LIKE PEPTIDE 1 RECEPTOR PRECURSOR (GLP-1 RECEPTOR) (GLP-1-R) (GLP-1R). [SOURCE:UNIPROT/SWISSPROT;ACC:P43220]	Description
ENSG00000112164	Ensembl Gene Id

GLP1R	GENE_SYMBOL
Glucagon-like peptide 1 receptor	UNIPROT
GLP-1 receptor	UNIPROT

GLP1R Gene Record

GLP1R 2740 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glucagon-like peptide 1 receptor agonist Trial Name PC-DAC:Exendin-4

PMIDs: 30883264 16722815 15495988 15700891 17353295 20649595 16534527 15331551 16341288 17292977 11752352 16627399 17379930

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name NN9924 Novel drug target Established target Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

PMIDs: 18333889 14678021 25991051

Sources: TdgClinicalTrial ChemblInteractions PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucagon-like peptide 1 receptor agonist Direct Interaction yes

PMIDs: 24140094 21314233

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucagon-like peptide 1 receptor agonist Direct Interaction yes Trial Name albiglutide, GSK716155,Syncria

PMIDs: 25136065

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucagon-like peptide 1 receptor agonist Direct Interaction yes Trial Name LY-2189265

PMIDs: 25367716

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucagon-like peptide 1 receptor agonist Direct Interaction yes Trial Name taspoglutide, ITM-077, R1583, BIM-51077

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Glucagon-like peptide 1 receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27160388

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Trial Name PC-DAC:Exendin-4

PMIDs:
30883264 16722815 15495988 15700891 17353295 20649595 16534527 15331551 16341288 17292977 11752352 16627399 17379930

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name NN9924

Novel drug target Established target

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

PMIDs:
18333889 14678021 25991051

Sources:
TdgClinicalTrial ChemblInteractions PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

PMIDs:
24140094 21314233

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

Trial Name albiglutide, GSK716155,Syncria

PMIDs:
25136065

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

Trial Name LY-2189265

PMIDs:
25367716

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

Trial Name taspoglutide, ITM-077, R1583, BIM-51077

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Glucagon-like peptide 1 receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
27160388

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
27160388

Sources:
PharmGKB

Interaction Types & Directionality:

n/a