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GHRL Gene Record

  • Summary
  • Interactions
  • Claims
  • GHRL 51738 Druggable Genome

    Alternate Names:

    51738
    GHRELIN AND OBESTATIN PREPROPEPTIDE
    GHRL
    MTLRP
    605353
    18129
    ENSG00000157017
    OTTHUMG00000155360
    Q9UBU3
    GHR
    Ghrelin
    T06850

    Gene Info:

    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor
    Target Class Miscellaneous
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Brzozowski et al., 2006, Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury., J. Pharmacol. Exp. Ther.
    Lambrinoudaki et al., 2008, Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene., Maturitas
    Otto et al., 2006, Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels., J. Endocrinol. Invest.
    Perez-Iglesias et al., 2008, Effect of antipsychotics on peptides involved in energy balance in drug-naive psychotic patients after 1 year of treatment., J Clin Psychopharmacol
    Paik et al., 2007, Marked suppression of ghrelin concentration by insulin in Prader-willi syndrome., J. Korean Med. Sci.
    Sibilia et al., 2008, Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk., Br. J. Pharmacol.
    Wang et al., 2007, Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet., Metab. Clin. Exp.
    Wang et al., 2006, LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications., Am. J. Physiol. Gastrointest. Liver Physiol.
    Xu et al., 2008, Ghrelin prevents doxorubicin-induced cardiotoxicity through TNF-alpha/NF-kappaB pathways and mitochondrial protective mechanisms., Toxicology
    Mundinger et al., 2006, Direct stimulation of ghrelin secretion by sympathetic nerves., Endocrinology
  • RELAMORELIN   GHRL

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PSYLLIUM SEED HUSKS   GHRL

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17998014


    Sources:
    NCI

  • MACIMORELIN   GHRL

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ARD-07
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ROFECOXIB   GHRL

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16868036


    Sources:
    NCI

  • ANAKINRA   GHRL

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16959954


    Sources:
    NCI

  • PIOGLITAZONE   GHRL

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16682836


    Sources:
    NCI

  • ETANERCEPT   GHRL

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18400355


    Sources:
    NCI

  • RALOXIFENE   GHRL

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18164562


    Sources:
    NCI

  • EPINEPHRINE   GHRL

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16527847


    Sources:
    NCI

  • INSULIN   GHRL

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17449920


    Sources:
    NCI

  • RISPERIDONE   GHRL

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18480685


    Sources:
    NCI

  • CELECOXIB   GHRL

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18414388


    Sources:
    NCI

  • Ensembl: ENSG00000157017

    • Version: 101_38

    Alternate Names:
    GHRL Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q9UBU3

    • Version: January-2014

    Alternate Names:
    GHR Gene Symbol
    GHRL Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor

    Publications:

  • NCI: GHRL

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Otto et al., 2006, Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels., J. Endocrinol. Invest.
    Wang et al., 2007, Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet., Metab. Clin. Exp.
    Collins et al., 2007, Modulation of apolipoprotein A1 and B, adiponectin, ghrelin, and growth hormone concentrations by plant sterols and exercise in previously sedentary humans., Can. J. Physiol. Pharmacol.

  • HingoraniCasas: ENSG00000157017

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000157017 Gene Symbol
    GHRL Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Ghrelin

    • Version: 2020.06.01

    Alternate Names:
    GHRL TTD Gene Abbreviation
    T06850 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21