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GGT1 Gene Record

  • Summary
  • Interactions
  • Claims
  • GGT1 2678 Druggable Genome

    Alternate Names:

    2678
    GAMMA-GLUTAMYLTRANSFERASE 1
    GGT1
    CD224
    D22S672
    D22S732
    GGT
    GGT 1
    GTG
    612346
    4250
    ENSG00000100031
    OTTHUMG00000030859
    P19440
    ENSG00000286070
    GGTD
    Glutathione hydrolase 1 proenzyme

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Helander et al., 1996, Carbohydrate-deficient transferrin and gamma-glutamyl transferase levels during disulfiram therapy., Alcohol. Clin. Exp. Res.
    van der Harst et al., 2005, Gentamicin nephrotoxicity--a comparison of in vitro findings with in vivo experiments in equines., Vet. Res. Commun.
    Edwards et al., 1987, Modulation of gamma-glutamyltranspeptidase in normal rat hepatocytes in culture by cell density, epidermal growth factor and agents which alter cell differentiation., Carcinogenesis
    Kocaoğlu et al., 1997, Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity., Arch. Immunol. Ther. Exp. (Warsz.)
    Ishii et al., 2001, Effects of renal sorbitol accumulation on urinary excretion of enzymes in hyperglycaemic rats., Ann. Clin. Biochem.
    el Yaagoubi et al., 1998, 5-Azacytidine modulates gamma-glutamyltransferase and glutathione levels in two human prostatic adenocarcinoma cell lines., Biochem. Mol. Biol. Int.
    Maggiore et al., 1982, [Effects of dithiocarbamate: "in vitro" and "in vivo" changes in gamma-glutamyltransferase induced by sodium diethyldithiocarbamate]., Quad Sclavo Diagn
    Yager et al., 1984, Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol., Cancer Res.
    Yager et al., 1986, Effects of ethinyl estradiol and tamoxifen on liver DNA turnover and new synthesis and appearance of gamma glutamyl transpeptidase-positive foci in female rats., Carcinogenesis
    Day et al., 1990, gamma-Glutamyltranspeptidase in rat bronchoalveolar lavage fluid as a probe of 4-ipomeanol and alpha-naphthylthiourea-induced pneumotoxicity., J Pharmacol Methods
    Tutor-Crespo et al., [A study of some indirect biochemical markers in the evaluation of enzymatic induction caused by antiepileptic drugs]., Rev Neurol
    Demori et al., 1995, Triiodothyronine decreases gammaglutamyltranspeptidase expression in cultured rat hepatocytes., Horm. Metab. Res.
    Bonneterre et al., 1987, Variations in lipoproteins during aminoglutethimide therapy., Breast Cancer Res. Treat.
    Holmes et al., 1983, Effect of cannabinoids on human Sertoli cell function in vitro., Arch. Androl.
    Morsi et al., 2006, Evaluation of tumour necrosis factor-alpha, soluble P-selectin, gamma-glutamyl transferase, glutathione S-transferase-pi and alpha-fetoprotein in patients with hepatocellular carcinoma before and during chemotherapy., Br. J. Biomed. Sci.
    Calandre et al., The effect of chronic phenytoin treatment on serum lipid profile in adult epileptic patients., Epilepsia
  • CHEMBL1743358   GGT1

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1976855


    Sources:
    NCI

  • CANNABINOL   GGT1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6140904


    Sources:
    NCI

  • MANNITOL   GGT1

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11471882


    Sources:
    NCI

  • AMINOGLUTETHIMIDE   GGT1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3427227


    Sources:
    NCI

  • DITIOCARB   GGT1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6135240


    Sources:
    NCI

  • MESTRANOL   GGT1

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6744303


    Sources:
    NCI

  • PIROXICAM   GGT1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9090444


    Sources:
    NCI

  • ADRIAMYCIN   GGT1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16871999


    Sources:
    NCI

  • DICLOFENAC   GGT1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9090444


    Sources:
    NCI

  • GENTAMICIN   GGT1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15736857


    Sources:
    NCI

  • PHENYTOIN   GGT1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1346382 12402220


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   GGT1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7642172


    Sources:
    NCI

  • AZACITIDINE   GGT1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9801800


    Sources:
    NCI

  • INDOMETHACIN   GGT1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9090444


    Sources:
    NCI

  • DISULFIRAM   GGT1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8904971


    Sources:
    NCI

  • CARBAMAZEPINE   GGT1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12402220


    Sources:
    NCI

  • TAMOXIFEN   GGT1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2877750


    Sources:
    NCI

  • DEXAMETHASONE   GGT1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2890444


    Sources:
    NCI

  • Ensembl: ENSG00000100031

    • Version: 101_38

    Alternate Names:
    GGT1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: GGT1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    van der Harst et al., 2005, Gentamicin nephrotoxicity--a comparison of in vitro findings with in vivo experiments in equines., Vet. Res. Commun.
    Kocaoğlu et al., 1997, Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity., Arch. Immunol. Ther. Exp. (Warsz.)
    Tutor-Crespo et al., [A study of some indirect biochemical markers in the evaluation of enzymatic induction caused by antiepileptic drugs]., Rev Neurol

  • HingoraniCasas: ENSG00000100031

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100031 Gene Symbol
    GGT1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: GGT1

    • Version: 19.3

    Alternate Names:
    ENSG00000100031 Ensembl Gene ID
    CD224 Human Protein Atlas Gene Synonym
    D22S672 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, ENZYME

    Publications:

  • dGene: GGT1

    • Version: 27-Jun-2013

    Alternate Names:
    2678 Gene ID
    CD224 dGene Synonym
    D22S672 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • Pharos: GGT1

    • Version: 01-February-2022

    Alternate Names:
    Glutathione hydrolase 1 proenzyme Gene Name
    P19440 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21