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GDNF Gene Record

  • Summary
  • Interactions
  • Claims
  • GDNF 2668 Druggable Genome

    Alternate Names:

    2668
    GLIAL CELL DERIVED NEUROTROPHIC FACTOR
    GDNF
    ATF
    ATF1
    ATF2
    HFB1-GDNF
    HSCR3
    600837
    4232
    ENSG00000168621
    OTTHUMG00000090809
    P39905
    BE0002486
    PA28644
    Glial cell line-derived neurotrophic factor
    T79160

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Shao et al., 2006, Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells., J Psychiatry Neurosci
    Wang XC et al., 2014, Association of 2 neurotrophic factor polymorphisms with efficacy of paroxetine in patients with major depressive disorder in a Chinese population., Ther Drug Monit
    Ohta et al., 2003, Effects of dopamine agonists bromocriptine, pergolide, cabergoline, and SKF-38393 on GDNF, NGF, and BDNF synthesis in cultured mouse astrocytes., Life Sci.
    McAlhany et al., 1999, Ethanol decreases Glial-Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum., Alcohol. Clin. Exp. Res.
    Suzuki et al., 2000, Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity., Gene Ther.
    Nandini CD et al., 2004, Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors., J Biol Chem
  • LIATERMIN   GDNF

    Interaction Score: 8.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHONDROITIN SULFATE   GDNF

    Interaction Score: 4.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15385557


    Sources:
    DrugBank

  • GENTAMICIN   GDNF

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10871754


    Sources:
    NCI

  • BROMOCRIPTINE   GDNF

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12770616


    Sources:
    NCI

  • PAROXETINE   GDNF

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24577123


    Sources:
    PharmGKB

  • CLOZAPINE   GDNF

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16496033


    Sources:
    NCI

  • ALCOHOL   GDNF

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10550003


    Sources:
    NCI

  • Ensembl: ENSG00000168621

    • Version: 101_38

    Alternate Names:
    GDNF Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: GDNF

    • Version: 18-August-2020

    Alternate Names:
    PA28644 PharmGKB ID

    Gene Info:

    Publications:
    Wang XC et al., 2014, Association of 2 neurotrophic factor polymorphisms with efficacy of paroxetine in patients with major depressive disorder in a Chinese population., Ther Drug Monit

  • DrugBank: BE0002486

    • Version: 5.1.7

    Alternate Names:
    GDNF DrugBank Gene Name
    P39905 UniProt Accession
    2668 Entrez Gene Id

    Gene Info:

    Publications:
    Nandini CD et al., 2004, Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors., J Biol Chem

  • NCI: GDNF

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ohta et al., 2003, Effects of dopamine agonists bromocriptine, pergolide, cabergoline, and SKF-38393 on GDNF, NGF, and BDNF synthesis in cultured mouse astrocytes., Life Sci.
    Kawamoto et al., 2003, Hearing and hair cells are protected by adenoviral gene therapy with TGF-beta1 and GDNF., Mol. Ther.
    Ozden et al., 2004, Neuroprotective properties of different anesthetics on axotomized rat retinal ganglion cells in vivo., J. Neurotrauma

  • HingoraniCasas: ENSG00000168621

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000168621 Gene Symbol
    GDNF Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: GDNF

    • Version: 03-September-2020

    Alternate Names:
    Glial cell line-derived neurotrophic factor Gene Name
    P39905 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • TTD: Glial cell line-derived neurotrophic factor

    • Version: 2020.06.01

    Alternate Names:
    GDNF TTD Gene Abbreviation
    T79160 TTD Target ID

    Gene Info:

    Publications:

  • GO: GDNF

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21