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GCLM Gene Record

  • Summary
  • Interactions
  • Claims
  • GCLM 2730

    Alternate Names:

    2730
    GLUTAMATE-CYSTEINE LIGASE MODIFIER SUBUNIT
    GCLM
    GLCLR
    601176
    4312
    ENSG00000023909
    OTTHUMG00000010562
    Glutamate--cysteine ligase regulatory subunit
    P48507

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    ENZYME

    Publications:

    Iida et al., 1999, Co-expression of gamma-glutamylcysteine synthetase sub-units in response to cisplatin and doxorubicin in human cancer cells., Int. J. Cancer
    Brooks et al., 2001, Potent induction of phase 2 enzymes in human prostate cells by sulforaphane., Cancer Epidemiol. Biomarkers Prev.
    Urata et al., 1999, Melatonin induces gamma-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells., Free Radic. Biol. Med.
  • SULFORAPHANE   GCLM

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11535546


    Sources:
    NCI

  • MELATONIN   GCLM

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10515588


    Sources:
    NCI

  • CISPLATIN   GCLM

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10399958


    Sources:
    NCI

  • Ensembl: ENSG00000023909

    • Version: 101_38

    Alternate Names:
    GCLM Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: GCLM

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Hamilton et al., 2003, Interaction of glucose and long chain fatty acids (C18) on antioxidant defences and free radical damage in porcine vascular smooth muscle cells in vitro., Diabetologia
    Ben-Dor et al., 2005, Carotenoids activate the antioxidant response element transcription system., Mol. Cancer Ther.
    Iida et al., 1999, Co-expression of gamma-glutamylcysteine synthetase sub-units in response to cisplatin and doxorubicin in human cancer cells., Int. J. Cancer

  • Pharos: GCLM

    • Version: 01-February-2022

    Alternate Names:
    Glutamate--cysteine ligase regulatory subunit Gene Name
    P48507 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21