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GCG Gene Record

  • Summary
  • Interactions
  • Claims
  • GCG 2641 Druggable Genome

    Alternate Names:

    2641
    GLUCAGON
    GCG
    GLP-1
    GLP1
    GLP2
    GRPP
    138030
    4191
    ENSG00000115263
    OTTHUMG00000153892
    PA28606
    T44919

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    HORMONE ACTIVITY
    DRUGGABLE GENOME

    Publications:

    Ciampelli et al., 1998, Opioid blockade effect on insulin beta-cells secretory patterns in polycystic ovary syndrome. Oral glucose load versus intravenous glucagon bolus., Horm. Res.
    Potter et al., 1980, Acute pretreatment with pyrazole and ethanol: effects on glucose-induced changes in insulin and glucagon., Pharmacology
    Ipp et al., 1980, Morphine-induced hyperglycemia: role of insulin and glucagon., Endocrinology
    Montrose-Rafizadeh et al., 1999, Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells., Endocrinology
    Coulie et al., 1998, 5-Hydroxytryptamine-1 receptor activation inhibits endocrine pancreatic secretion in humans., Am. J. Physiol.
    Choi et al., 1993, Factors affecting myocardial 2-[F-18]fluoro-2-deoxy-D-glucose uptake in positron emission tomography studies of normal humans., Eur J Nucl Med
    Christ et al., 1993, The glucagon-insulin antagonism in the regulation of cytosolic protein binding to the 3' end of phosphoenolpyruvate carboxykinase mRNA in cultured rat hepatocytes. Possible involvement in the stabilization of the mRNA., Eur. J. Biochem.
    Passariello et al., 1982, A possible role of gamma-aminobutyric acid in the control of the endocrine pancreas., J. Clin. Endocrinol. Metab.
    Brandl EJ et al., 2014, Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain., Pharmacogenomics
    Rinaman et al., 2002, GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Dammann et al., 1994, Effects of pantoprazole on endocrine function in healthy male volunteers., Aliment. Pharmacol. Ther.
    McGrowder et al., 2001, Effects of S-nitroso-N-acetyl-penicillamine administration on glucose tolerance and plasma levels of insulin and glucagon in the dog., Nitric Oxide
  • COTADUTIDE   GCG

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • EFINOPEGDUTIDE   GCG

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CORDYCEPIN   GCG

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8354260


    Sources:
    NCI

  • LORNOXICAM   GCG

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10067836


    Sources:
    NCI

  • PYRAZOLE   GCG

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6992153


    Sources:
    NCI

  • FLUDEOXYGLUCOSE-F18   GCG

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8491223


    Sources:
    NCI

  • SAR425899   GCG

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PENICILLAMINE   GCG

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11485378


    Sources:
    NCI

  • PANTOPRAZOLE   GCG

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7865648


    Sources:
    NCI

  • NALTREXONE   GCG

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9623517


    Sources:
    NCI

  • OXYTOCIN   GCG

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12069935


    Sources:
    NCI

  • BACLOFEN   GCG

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7042732


    Sources:
    NCI

  • SUMATRIPTAN   GCG

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9486164


    Sources:
    NCI

  • MORPHINE   GCG

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6993188


    Sources:
    NCI

  • CLOZAPINE   GCG

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24624910


    Sources:
    PharmGKB

  • OLANZAPINE   GCG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24624910


    Sources:
    PharmGKB

  • Ensembl: ENSG00000115263

    • Version: 101_38

    Alternate Names:
    GCG Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: GCG

    • Version: 18-August-2020

    Alternate Names:
    PA28606 PharmGKB ID

    Gene Info:

    Publications:
    Brandl EJ et al., 2014, Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain., Pharmacogenomics

  • NCI: GCG

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Potter et al., 1980, Acute pretreatment with pyrazole and ethanol: effects on glucose-induced changes in insulin and glucagon., Pharmacology
    Montrose-Rafizadeh et al., 1999, Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells., Endocrinology
    Itoh et al., 1982, Adrenergic modulation of pancreatic somatostatin, insulin, and glucagon secretion: evidence for differential sensitivity of islet A, B, and D cells., Metab. Clin. Exp.

  • HingoraniCasas: ENSG00000115263

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000115263 Gene Symbol
    GCG Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Glucagon

    • Version: 2020.06.01

    Alternate Names:
    GCG TTD Gene Abbreviation
    T44919 TTD Target ID

    Gene Info:

    Publications:

  • GO: GCG

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    HORMONE ACTIVITY

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21