DGIdb - GCG Gene Record

GCG 2641 Druggable Genome

Alternate Names:

2641
GLUCAGON
GCG
GLP-1
GLP1
GLP2
GRPP
138030
4191
ENSG00000115263
OTTHUMG00000153892
PA28606
T44919

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

HORMONE ACTIVITY
DRUGGABLE GENOME

Publications:

Ciampelli et al., 1998, Opioid blockade effect on insulin beta-cells secretory patterns in polycystic ovary syndrome. Oral glucose load versus intravenous glucagon bolus., Horm. Res.
Potter et al., 1980, Acute pretreatment with pyrazole and ethanol: effects on glucose-induced changes in insulin and glucagon., Pharmacology
Ipp et al., 1980, Morphine-induced hyperglycemia: role of insulin and glucagon., Endocrinology
Montrose-Rafizadeh et al., 1999, Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells., Endocrinology
Coulie et al., 1998, 5-Hydroxytryptamine-1 receptor activation inhibits endocrine pancreatic secretion in humans., Am. J. Physiol.
Choi et al., 1993, Factors affecting myocardial 2-[F-18]fluoro-2-deoxy-D-glucose uptake in positron emission tomography studies of normal humans., Eur J Nucl Med
Christ et al., 1993, The glucagon-insulin antagonism in the regulation of cytosolic protein binding to the 3' end of phosphoenolpyruvate carboxykinase mRNA in cultured rat hepatocytes. Possible involvement in the stabilization of the mRNA., Eur. J. Biochem.
Passariello et al., 1982, A possible role of gamma-aminobutyric acid in the control of the endocrine pancreas., J. Clin. Endocrinol. Metab.
Brandl EJ et al., 2014, Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain., Pharmacogenomics
Rinaman et al., 2002, GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Dammann et al., 1994, Effects of pantoprazole on endocrine function in healthy male volunteers., Aliment. Pharmacol. Ther.
McGrowder et al., 2001, Effects of S-nitroso-N-acetyl-penicillamine administration on glucose tolerance and plasma levels of insulin and glucagon in the dog., Nitric Oxide

COTADUTIDE GCG

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
EFINOPEGDUTIDE GCG

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CORDYCEPIN GCG

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8354260

Sources:
NCI
LORNOXICAM GCG

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10067836

Sources:
NCI
PYRAZOLE GCG

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6992153

Sources:
NCI
FLUDEOXYGLUCOSE-F18 GCG

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8491223

Sources:
NCI
SAR425899 GCG

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PENICILLAMINE GCG

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11485378

Sources:
NCI
PANTOPRAZOLE GCG

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7865648

Sources:
NCI
NALTREXONE GCG

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9623517

Sources:
NCI
OXYTOCIN GCG

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12069935

Sources:
NCI
BACLOFEN GCG

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7042732

Sources:
NCI
SUMATRIPTAN GCG

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9486164

Sources:
NCI
MORPHINE GCG

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6993188

Sources:
NCI
CLOZAPINE GCG

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24624910

Sources:
PharmGKB
OLANZAPINE GCG

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24624910

Sources:
PharmGKB

Ensembl: ENSG00000115263
- Version: 101_38
Alternate Names:

GCG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: GCG
- Version: 18-August-2020
Alternate Names:

PA28606 PharmGKB ID

Gene Info:

Publications:

Brandl EJ et al., 2014, Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain., Pharmacogenomics

NCI: GCG

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Potter et al., 1980, Acute pretreatment with pyrazole and ethanol: effects on glucose-induced changes in insulin and glucagon., Pharmacology

Montrose-Rafizadeh et al., 1999, Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells., Endocrinology

Itoh et al., 1982, Adrenergic modulation of pancreatic somatostatin, insulin, and glucagon secretion: evidence for differential sensitivity of islet A, B, and D cells., Metab. Clin. Exp.

HingoraniCasas: ENSG00000115263
- Version: 31-May-2017
Alternate Names:

ENSG00000115263 Gene Symbol

GCG Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Glucagon
- Version: 2020.06.01
Alternate Names:

GCG TTD Gene Abbreviation

T44919 TTD Target ID

Gene Info:

Publications:
GO: GCG
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

HORMONE ACTIVITY

Publications:

GCG Gene Record

GCG 2641 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8354260

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10067836

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6992153

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8491223

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11485378

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7865648

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9623517

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12069935

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7042732

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9486164

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6993188

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24624910

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24624910

Sources: PharmGKB

Ensembl: ENSG00000115263

Alternate Names: GCG Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: GCG

Alternate Names: PA28606 PharmGKB ID

Gene Info:

Publications: Brandl EJ et al., 2014, Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain., Pharmacogenomics

NCI: GCG

Alternate Names:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8354260

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10067836

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6992153

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8491223

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
11485378

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7865648

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9623517

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12069935

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7042732

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9486164

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6993188

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24624910

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24624910

Sources:
PharmGKB

Alternate Names:

GCG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA28606 PharmGKB ID

Publications:

Brandl EJ et al., 2014, Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain., Pharmacogenomics

Alternate Names:

ENSG00000115263 Gene Symbol

GCG Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GCG TTD Gene Abbreviation

T44919 TTD Target ID

Gene Categories:

HORMONE ACTIVITY