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GART Gene Record

  • Summary
  • Interactions
  • Claims
  • GART 2618 Druggable Genome

    Alternate Names:

    2618
    PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE, PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE, PHOSPHORIBOSYLAMINOIMIDAZOLE SYNTHETASE
    GART
    AIRS
    GARS
    GARTF
    PAIS
    PGFT
    PRGS
    138440
    4163
    ENSG00000159131
    OTTHUMG00000065628
    P22102
    PUR2_HUMAN
    Glycinamide ribonucleotide synthetase
    Trifunctional purine biosynthetic protein adenosine-3
    GAR transformylase
    Phosphoribosylamine--glycine ligase
    Phosphoribosylformylglycinamidine cyclo-ligase
    5'-phosphoribosylglycinamide transformylase
    Phosphoribosyl-aminoimidazole synthetase
    Phosphoribosylglycinamide formyltransferase
    AIR synthase
    Phosphoribosylglycinamide synthetase
    T72042
    Glycinamide ribonucleotide formyltransferase
    T89918

    Gene Info:

    Target Subclass 6.3.4.13
    Target Main Class Enzymes
    Target Class Enzymes
    Target Subclass EC:6.3.4.13
    Target Subclass 6.3.3.1
    Target Subclass 2.1.2.2
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Pivot et al., 2001, Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck., Br. J. Cancer
    Kindler, 2002, Pemetrexed in pancreatic cancer., Semin. Oncol.
    Hanauske et al., 2001, Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors., Oncologist
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Adjei, 2001, Gemcitabine and Pemetrexed disodium in treating breast cancer., Oncology (Williston Park, N.Y.)
    Adjei, 2002, Pemetrexed in the treatment of selected solid tumors., Semin. Oncol.
    Giovannetti et al., 2005, Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells., Mol. Pharmacol.
    Schultz et al., Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells., Anticancer Res.
    Adjei, 2001, Gemcitabine and pemetrexed disodium combinations in vitro and in vivo., Lung Cancer
    Molina et al., 2003, The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy., Clin Lung Cancer
    Wang L et al., 2012, Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier., J Med Chem
  • PELITREXOL   GART

    Interaction Score: 20.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PEMETREXED   GART

    Interaction Score: 17.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Trial Name Alimta

    PMIDs:
    11531245 12571811 11524555 10592235 11252887 12023793 15795320 11848474 11742712 14596699


    Sources:
    TdgClinicalTrial TEND

  • LOMETREXOL   GART

    Interaction Score: 8.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22243528


    Sources:
    DTC

  • Ensembl: ENSG00000159131

    • Version: 101_38

    Alternate Names:
    GART Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P22102

    • Version: 01-August-2011

    Alternate Names:
    PUR2_HUMAN Uniprot Id
    P22102 Uniprot Accession
    2618 Entrez Gene Id

    Gene Info:
    Target Subclass 6.3.4.13
    Target Main Class Enzymes
    Target Subclass 6.3.3.1

    Publications:

  • TdgClinicalTrial: P22102

    • Version: January-2014

    Alternate Names:
    GART Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:6.3.4.13
    Target Subclass 6.3.3.1

    Publications:

  • DTC: GART

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wang L et al., 2012, Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier., J Med Chem

  • HingoraniCasas: ENSG00000159131

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000159131 Gene Symbol
    GART Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: PGFT

    • Version: chembl_23

    Alternate Names:
    GAR transformylase UNIPROT
    PRGS GENE_SYMBOL
    GART GENE_SYMBOL

    Gene Info:

    Publications:

  • TTD: Glycinamide ribonucleotide formyltransferase

    • Version: 2020.06.01

    Alternate Names:
    GART TTD Gene Abbreviation
    T89918 TTD Target ID

    Gene Info:

    Publications:

  • TTD: GAR transformylase

    • Version: 2020.06.01

    Alternate Names:
    GART TTD Gene Abbreviation
    T72042 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: GART

    • Version: 01-February-2022

    Alternate Names:
    Trifunctional purine biosynthetic protein adenosine-3 Gene Name
    P22102 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21