DGIdb - GART Gene Record

GART 2618 Druggable Genome

Alternate Names:

2618
PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE, PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE, PHOSPHORIBOSYLAMINOIMIDAZOLE SYNTHETASE
GART
AIRS
GARS
GARTF
PAIS
PGFT
PRGS
138440
4163
ENSG00000159131
OTTHUMG00000065628
P22102
PUR2_HUMAN
Glycinamide ribonucleotide synthetase
Trifunctional purine biosynthetic protein adenosine-3
GAR transformylase
Phosphoribosylamine--glycine ligase
Phosphoribosylformylglycinamidine cyclo-ligase
5'-phosphoribosylglycinamide transformylase
Phosphoribosyl-aminoimidazole synthetase
Phosphoribosylglycinamide formyltransferase
AIR synthase
Phosphoribosylglycinamide synthetase
T72042
Glycinamide ribonucleotide formyltransferase
T89918

Gene Info:

Target Subclass	6.3.4.13
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:6.3.4.13
Target Subclass	6.3.3.1
Target Subclass	2.1.2.2
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Pivot et al., 2001, Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck., Br. J. Cancer
Kindler, 2002, Pemetrexed in pancreatic cancer., Semin. Oncol.
Hanauske et al., 2001, Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors., Oncologist
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Adjei, 2001, Gemcitabine and Pemetrexed disodium in treating breast cancer., Oncology (Williston Park, N.Y.)
Adjei, 2002, Pemetrexed in the treatment of selected solid tumors., Semin. Oncol.
Giovannetti et al., 2005, Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells., Mol. Pharmacol.
Schultz et al., Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells., Anticancer Res.
Adjei, 2001, Gemcitabine and pemetrexed disodium combinations in vitro and in vivo., Lung Cancer
Molina et al., 2003, The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy., Clin Lung Cancer
Wang L et al., 2012, Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier., J Med Chem

PELITREXOL GART

Interaction Score: 20.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PEMETREXED GART

Interaction Score: 17.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Trial Name Alimta

PMIDs:
11531245 12571811 11524555 10592235 11252887 12023793 15795320 11848474 11742712 14596699

Sources:
TdgClinicalTrial TEND
LOMETREXOL GART

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22243528

Sources:
DTC

Ensembl: ENSG00000159131
- Version: 101_38
Alternate Names:

GART Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P22102
- Version: 01-August-2011
Alternate Names:

PUR2_HUMAN Uniprot Id

P22102 Uniprot Accession

2618 Entrez Gene Id

Gene Info:

Target Subclass 6.3.4.13

Target Main Class Enzymes

Target Subclass 6.3.3.1

Publications:
TdgClinicalTrial: P22102
- Version: January-2014
Alternate Names:

GART Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:6.3.4.13

Target Subclass 6.3.3.1

Publications:

DTC: GART

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wang L et al., 2012, Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier., J Med Chem

HingoraniCasas: ENSG00000159131
- Version: 31-May-2017
Alternate Names:

ENSG00000159131 Gene Symbol

GART Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PGFT
- Version: chembl_23
Alternate Names:

GAR transformylase UNIPROT

PRGS GENE_SYMBOL

GART GENE_SYMBOL

Gene Info:

Publications:
TTD: Glycinamide ribonucleotide formyltransferase
- Version: 2020.06.01
Alternate Names:

GART TTD Gene Abbreviation

T89918 TTD Target ID

Gene Info:

Publications:
TTD: GAR transformylase
- Version: 2020.06.01
Alternate Names:

GART TTD Gene Abbreviation

T72042 TTD Target ID

Gene Info:

Publications:
Pharos: GART
- Version: 01-February-2022
Alternate Names:

Trifunctional purine biosynthetic protein adenosine-3 Gene Name

P22102 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Trial Name	-
Novel drug target	Established target
Trial Name	Alimta

PUR2_HUMAN	Uniprot Id
P22102	Uniprot Accession
2618	Entrez Gene Id

Trifunctional purine biosynthetic protein adenosine-3	Gene Name
P22102	UniProt ID

GART Gene Record

GART 2618 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PELITREXOL GART

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

PEMETREXED GART

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Trial Name Alimta

PMIDs: 11531245 12571811 11524555 10592235 11252887 12023793 15795320 11848474 11742712 14596699

Sources: TdgClinicalTrial TEND

LOMETREXOL GART

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22243528

Sources: DTC

Ensembl: ENSG00000159131

Alternate Names: GART Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P22102

Alternate Names: PUR2_HUMAN Uniprot Id P22102 Uniprot Accession 2618 Entrez Gene Id

Gene Info: Target Subclass 6.3.4.13 Target Main Class Enzymes Target Subclass 6.3.3.1

Publications:

TdgClinicalTrial: P22102

Alternate Names: GART Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:6.3.4.13 Target Subclass 6.3.3.1

Publications:

DTC: GART

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000159131

Alternate Names: ENSG00000159131 Gene Symbol GART Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: PGFT

Alternate Names: GAR transformylase UNIPROT PRGS GENE_SYMBOL GART GENE_SYMBOL

Gene Info:

Publications:

TTD: Glycinamide ribonucleotide formyltransferase

Alternate Names: GART TTD Gene Abbreviation T89918 TTD Target ID

Gene Info:

Publications:

TTD: GAR transformylase

Alternate Names: GART TTD Gene Abbreviation T72042 TTD Target ID

Gene Info:

Publications:

Pharos: GART

Alternate Names: Trifunctional purine biosynthetic protein adenosine-3 Gene Name P22102 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Trial Name Alimta

PMIDs:
11531245 12571811 11524555 10592235 11252887 12023793 15795320 11848474 11742712 14596699

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
22243528

Sources:
DTC

Alternate Names:

GART Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PUR2_HUMAN Uniprot Id

P22102 Uniprot Accession

2618 Entrez Gene Id

Gene Info:

Target Subclass 6.3.4.13

Target Main Class Enzymes

Target Subclass 6.3.3.1

Alternate Names:

GART Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:6.3.4.13

Target Subclass 6.3.3.1

Alternate Names:

ENSG00000159131 Gene Symbol

GART Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GAR transformylase UNIPROT

PRGS GENE_SYMBOL

GART GENE_SYMBOL

Alternate Names:

GART TTD Gene Abbreviation

T89918 TTD Target ID

Alternate Names:

GART TTD Gene Abbreviation

T72042 TTD Target ID

Alternate Names:

Trifunctional purine biosynthetic protein adenosine-3 Gene Name

P22102 UniProt ID

Gene Categories:

ENZYME