2565 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR GAMMA1 SUBUNIT |
GABRG1 |
137166 |
4086 |
ENSG00000163285 |
OTTHUMG00000128609 |
GABA(A) receptor subunit gamma-1 |
Gamma-aminobutyric acid receptor subunit gamma-1 |
Q8N1C3 |
GBRG1_HUMAN |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR GAMMA-1 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8N1C3] |
gamma-aminobutyric acid type A receptor subunit gamma1 |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Human Readable Name | ION CHANNEL |
Interpro Acc | IPR006202 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR006201 |
Interpro Short Name | Neur_channel |
Interpro Type | Domain |
Uniprot Evidence | 2: Evidence at transcript level |
Interpro Short Name | Neur_chan_lig-bd |
Uniprot Status | Swiss-Prot |
Interpro Type | Family |
Interpro Name | Neurotransmitter-gated ion-channel |
Target Subclass | cys-loop |
Transmembrane Helix Count | 4 |
Target Subclass | Channels |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Direct Interaction | yes |
potentiator |
Trial Name | - |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | NRL-01 |
positive modulator (activating) |
potentiator |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | Clobazam |
potentiator |
Novel drug target | Established target |
Trial Name | - |
positive modulator (activating) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
inverse agonist (inhibitory) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site inverse agonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site positive allosteric modulator |
Direct Interaction | yes |
potentiator |
Trial Name | - |
Novel drug target | Established target |
partial agonist (activating) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site partial agonist |
Direct Interaction | yes |
Trial Name | NG2-73 |
n/a |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Trial Name | alprazolam,Xanax, Xanax XR |
Novel drug target | Established target |
Trial Name | AZ-002, Staccato alprazolam |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Novel drug target | Established target |
Trial Name | gaboxadol |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | EHT 0202 |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | ocinaplon |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | CNS-7056 |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
GABRG1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000163285 | Ensembl Gene Id |
GBRG1_HUMAN | Uniprot Id |
2565 | Entrez Gene Id |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Human Readable Name | ION CHANNEL |
Interpro Acc | IPR006202 |
ION CHANNEL, DRUGGABLE GENOME |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR GAMMA-1 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8N1C3] | Description |
GABRG1 | Display Id |
ENSG00000163285 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
GABRG1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
ENSG00000163285 | Ensembl Gene Id |
GBRG1_HUMAN | Uniprot Id |
2565 | Entrez Gene Id |
Target Subclass | cys-loop |
Transmembrane Helix Count | 4 |
Target Subclass | Channels |
GABRG1 | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit gamma-1 | UNIPROT |
GABA(A) receptor subunit gamma-1 | UNIPROT |
ENSG00000163285 | Gene Symbol |
GABRG1 | Ensembl Id |
DRUGGABLE GENOME |
Gamma-aminobutyric acid receptor subunit gamma-1 | Gene Name |
Q8N1C3 | UniProt ID |
ION CHANNEL |