2563 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR DELTA SUBUNIT |
GABRD |
EIG10 |
EJM7 |
GEFSP5 |
137163 |
4084 |
ENSG00000187730 |
OTTHUMG00000041064 |
O14764 |
GBRD_HUMAN |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT DELTA |
GABA(A) receptor subunit delta |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR DELTA SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:O14764] |
GABA(A) receptor delta |
T27376 |
gamma-aminobutyric acid type A receptor subunit delta |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Target Subclass | Channels |
Target Subclass | Ligand_gated_ion_channels |
Transmembrane Helix Count | 4 |
Target Main Class | Receptors |
Target Subclass | cys-loop |
Uniprot Status | Swiss-Prot |
Interpro Type | Domain |
Interpro Acc | IPR006201 |
Interpro Type | Family |
Interpro Acc | IPR006202 |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Neur_chan_lig-bd |
Interpro Name | Neurotransmitter-gated ion-channel |
Interpro Short Name | Neur_channel |
Human Readable Name | DRUGGABLE GENOME |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Human Readable Name | ION CHANNEL |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | - |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
Novel drug target | Established target |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
potentiator |
Novel drug target | Established target |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | diazepam rectal gel |
positive modulator (activating) |
Trial Name | Clobazam |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Trial Name | JZP-8 |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Trial Name | AZ-002, Staccato alprazolam |
Novel drug target | Established target |
Trial Name | alprazolam,Xanax, Xanax XR |
n/a |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
n/a |
Trial Name | CNS-7056 |
Novel drug target | Established target |
n/a |
Trial Name | ocinaplon |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
Direct Interaction | yes |
n/a |
Trial Name | NG2-73 |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
GABRD | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
GABRD | Display Id |
ENSG00000187730 | Ensembl Gene Id |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR DELTA SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:O14764] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
GABRD | Gene Symbol |
ENSG00000187730 | Ensembl Gene Id |
GBRD_HUMAN | Uniprot Id |
Target Subclass | Channels |
Target Subclass | Ligand_gated_ion_channels |
Transmembrane Helix Count | 4 |
GABRD | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
GBRD_HUMAN | Uniprot Id |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT DELTA | Uniprot Protein Name |
GABRD | Uniprot Gene Name |
Uniprot Status | Swiss-Prot |
Interpro Type | Domain |
Interpro Acc | IPR006201 |
ION CHANNEL, DRUGGABLE GENOME |
GABRD | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit delta | UNIPROT |
GABA(A) receptor subunit delta | UNIPROT |
ENSG00000187730 | Gene Symbol |
GABRD | Ensembl Id |
DRUGGABLE GENOME |
GABRD | TTD Gene Abbreviation |
T27376 | TTD Target ID |
Gamma-aminobutyric acid receptor subunit delta | Gene Name |
O14764 | UniProt ID |
ION CHANNEL |