2558 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR ALPHA5 SUBUNIT |
GABRA5 |
137142 |
4079 |
ENSG00000186297 |
OTTHUMG00000171824 |
GABA(A) receptor subunit alpha-5 |
Gamma-aminobutyric acid receptor subunit alpha-5 |
P31644 |
GBRA5_HUMAN |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-5 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P31644] |
408 |
NP_000801 |
NM_000810 |
GABA<sub>A</sub> receptor α5 subunit |
BE0000471 |
GABA(A) receptor alpha-5 |
T26368 |
gamma-aminobutyric acid type A receptor subunit alpha5 |
Interpro Type | Domain |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR006201 |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR006202 |
Interpro Short Name | Neur_channel |
Uniprot Status | Swiss-Prot |
Interpro Type | Family |
Human Readable Name | ION CHANNEL |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Interpro Name | Neurotransmitter-gated ion-channel |
Interpro Short Name | Neur_chan_lig-bd |
GuideToPharmacology Gene Category Name | GABA<sub>A</sub> receptors |
GuideToPharmacology Gene Category ID | 72 |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Channels |
Transmembrane Helix Count | 4 |
Target Subclass | cys-loop |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Gene Biotype | PROTEIN_CODING |
TRANSPORTER |
ION CHANNEL |
DRUGGABLE GENOME |
allosteric modulator |
Details of the Assay for Interaction | Binding affinity determined in a radioligand displacement assay: test compound competition for [<sup>3</sup>H]flumazenil at α5β3γ2 GABA<sub>A</sub> channels transiently expressed in HEK293 cells. |
Specific Action of the Ligand | Negative |
Endogenous Drug? | False |
allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Specific Binding Site for Interaction | benzodiazepine site |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Novel drug target | Established target |
Trial Name | - |
allosteric modulator |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
agonist (activating) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | Lunesta |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
allosteric modulator |
Specific Binding Site for Interaction | benzodiazepine site |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | - |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | - |
n/a |
Trial Name | Ganaxolone |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Trial Name | diazepam rectal gel |
Novel drug target | Established target |
Trial Name | NRL-01 |
positive modulator (activating) |
allosteric modulator |
potentiator |
Novel drug target | Established target |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; agonist GABA site agonist |
Direct Interaction | yes |
Trial Name | gaboxadol |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
potentiator |
Novel drug target | Established target |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
allosteric modulator |
Specific Binding Site for Interaction | benzodiazepine site |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Novel drug target | Established target |
antagonist (inhibitory) |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
allosteric modulator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | AZ-002, Staccato alprazolam |
positive modulator (activating) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | JZP-8 |
antagonist (inhibitory) |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site positive allosteric modulator |
inverse agonist (inhibitory) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site inverse agonist |
Direct Interaction | yes |
agonist (activating) |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
allosteric modulator |
Trial Name | ocinaplon |
Novel drug target | Established target |
Specific Binding Site for Interaction | benzodiazepine site |
n/a |
Novel drug target | Established target |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
partial agonist (activating) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site partial agonist |
Direct Interaction | yes |
Trial Name | NG2-73 |
n/a |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Specific Binding Site for Interaction | GABA site |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Trial Name | CNS-7056 |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | - |
blocker (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | None |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
GABRA5 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000186297 | Ensembl Gene Id |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-5 | Uniprot Protein Name |
GBRA5_HUMAN | Uniprot Id |
Interpro Type | Domain |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR006201 |
ION CHANNEL, DRUGGABLE GENOME |
GABRA5 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
2558 | Entrez Gene Id |
ENSG00000186297 | Ensembl Gene Id |
GBRA5_HUMAN | Uniprot Id |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Channels |
GABRA5 | Display Id |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-5 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P31644] | Description |
ENSG00000186297 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
4079 | HUGO Gene ID |
4079 | HUGO Gene Symbol |
gamma-aminobutyric acid type A receptor subunit alpha5 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | GABA<sub>A</sub> receptors |
GuideToPharmacology Gene Category ID | 72 |
ION CHANNEL |
GABRA5 | DrugBank Gene Name |
P31644 | UniProt Accession |
2558 | Entrez Gene Id |
ENSG00000186297 | Gene Symbol |
GABRA5 | Ensembl Id |
DRUGGABLE GENOME |
GABRA5 | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit alpha-5 | UNIPROT |
GABA(A) receptor subunit alpha-5 | UNIPROT |
Gamma-aminobutyric acid receptor subunit alpha-5 | Gene Name |
P31644 | UniProt ID |
ION CHANNEL |
GABRA5 | TTD Gene Abbreviation |
T26368 | TTD Target ID |
TRANSPORTER |