2557 |
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR ALPHA4 SUBUNIT |
GABRA4 |
137141 |
4078 |
ENSG00000109158 |
OTTHUMG00000099431 |
P48169 |
GABRB2 |
GBRA4_HUMAN |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-4 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P48169] |
GABA(A) receptor subunit alpha-4 |
Gamma-aminobutyric acid receptor subunit alpha-4 |
gamma-aminobutyric acid type A receptor subunit alpha4 |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Channels |
Transmembrane Helix Count | 4 |
Target Subclass | cys-loop |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | Neur_chan_lig-bd |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Interpro Name | Neurotransmitter-gated ion-channel |
Interpro Acc | IPR006201 |
Interpro Acc | IPR006202 |
Human Readable Name | ION CHANNEL |
Interpro Short Name | Neur_channel |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Trial Name | - |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
n/a |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | - |
positive modulator (activating) |
potentiator |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
potentiator |
Trial Name | - |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
potentiator |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | ARX-03, sufentanil + triazolam NanoTab |
agonist (activating) |
Novel drug target | Established target |
Trial Name | gaboxadol |
Mechanism of Interaction | GABA-A receptor; agonist GABA site agonist |
potentiator |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | Clobazam |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | - |
positive modulator (activating) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | JZP-8 |
positive modulator (activating) |
potentiator |
Novel drug target | Established target |
Trial Name | - |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site positive allosteric modulator |
Direct Interaction | yes |
inverse agonist (inhibitory) |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site inverse agonist |
Direct Interaction | yes |
n/a |
Trial Name | Ganaxolone |
Novel drug target | Established target |
potentiator |
Trial Name | - |
Novel drug target | Established target |
partial agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; benzodiazepine site partial agonist |
Trial Name | NG2-73 |
n/a |
Trial Name | - |
Novel drug target | Established target |
positive modulator (activating) |
Trial Name | alprazolam,Xanax, Xanax XR |
Novel drug target | Established target |
Trial Name | AZ-002, Staccato alprazolam |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel agonist |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | CNS-7056 |
n/a |
Trial Name | ocinaplon |
Novel drug target | Established target |
n/a |
Trial Name | - |
Novel drug target | Established target |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel allosteric antagonist |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | GABA-A receptor; anion channel positive modulator |
Direct Interaction | yes |
GABRA4 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
GABRA4 | Gene Symbol |
GABRB2 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9 |
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-4 | Uniprot Protein Name |
GABRA4 | Uniprot Gene Name |
GBRA4_HUMAN | Uniprot Id |
Interpro Short Name | Neur_chan_lig-bd |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
ION CHANNEL, DRUGGABLE GENOME |
GBRA4_HUMAN | Uniprot Id |
2557 | Entrez Gene Id |
P48169 | Uniprot Accession |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Channels |
GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-4 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P48169] | Description |
GABRA4 | Display Id |
ENSG00000109158 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
GABRA4 | GENE_SYMBOL |
Gamma-aminobutyric acid receptor subunit alpha-4 | UNIPROT |
GABA(A) receptor subunit alpha-4 | UNIPROT |
ENSG00000109158 | Gene Symbol |
GABRA4 | Ensembl Id |
DRUGGABLE GENOME |
Gamma-aminobutyric acid receptor subunit alpha-4 | Gene Name |
P48169 | UniProt ID |
ION CHANNEL |