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GABRA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • GABRA1 2554 Druggable Genome

    Alternate Names:

    2554
    GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR ALPHA1 SUBUNIT
    GABRA1
    ECA4
    EIEE19
    EJM
    EJM5
    137160
    4075
    ENSG00000022355
    OTTHUMG00000163586
    GABA(A) receptor subunit alpha-1
    Gamma-aminobutyric acid receptor subunit alpha-1
    P14867
    GBRA1_HUMAN
    GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-1 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P14867]
    GABRD
    PA28489
    GABA(A) receptor alpha-1
    T51487
    gamma-aminobutyric acid type A receptor subunit alpha1
    DEE19

    Gene Info:

    Human Readable Name ION CHANNEL
    Interpro Short Name Neur_chan_lig-bd
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Neurotransmitter-gated ion-channel
    Interpro Acc IPR006202
    Interpro Name Neurotransmitter-gated ion-channel ligand-binding
    Interpro Type Domain
    Interpro Acc IPR006201
    Interpro Short Name Neur_channel
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Target Subclass Channels
    Target Subclass Ligand_gated_ion_channels
    Target Subclass cys-loop
    Target Main Class Receptors
    Transmembrane Helix Count 4
    Target Class Receptors
    Target Subclass TC:1.A.9
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.
    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Feigenspan et al., 2004, Electrophysiological properties of mouse horizontal cell GABAA receptors., J. Neurophysiol.
    Davies et al., 2001, Pressure-sensitive and -insensitive coupling in gamma-aminobutyric acid(A) receptors., Psychopharmacology (Berl.)
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Rahman et al., 2006, GABA-site antagonism and pentobarbital actions do not depend on the alpha-subunit type in the recombinant rat GABA receptor., Acta Physiol (Oxf)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Steinbach et al., 2001, Modulation of GABA(A) receptor channel gating by pentobarbital., J. Physiol. (Lond.)
    Koltchine et al., 1996, Chimeric GABAA/glycine receptors: expression and barbiturate pharmacology., Neuropharmacology
    Verster et al., 2004, Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature., CNS Drug Rev
    McCracken et al., 2010, A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics., J. Pharmacol. Exp. Ther.
    Seo et al., 2010, Genetic reduction of GABA(A) receptor gamma2 subunit expression potentiates the immobilizing action of isoflurane., Neurosci. Lett.
    Braga et al., 2009, Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 (GluR5) kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons., J. Pharmacol. Exp. Ther.
    Nowakowska et al., 2009, Memory improving and antidepressant effects of topiramate in rats., Arzneimittelforschung
    Garnett WR, 2000, Clinical pharmacology of topiramate: a review., Epilepsia
    Chung JY et al., 2014, Efficacy of zonisamide in migraineurs with nonresponse to topiramate., Biomed Res Int
    de Fiebre et al., 1992, Classical genetic analyses of responses to sedative-hypnotic drugs in crosses derived from long-sleep and short-sleep mice., Alcohol. Clin. Exp. Res.
    Lahti et al., 1983, Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine., Neuropharmacology
    Sethy et al., 1984, Determination of biological activity of adinazolam and its metabolites., J. Pharm. Pharmacol.
    Amin et al., 1997, Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors., Mol. Pharmacol.
    Wingrove et al., 2002, Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors., Eur. J. Pharmacol.
    Whitwam et al., 1995, Pharmacology of flumazenil., Acta Anaesthesiol Scand Suppl
    Iorio et al., 1984, Selective affinity of 1-N-trifluoroethyl benzodiazepines for cerebellar type 1 receptor sites., Life Sci.
    Wamsley et al., 1985, Autoradiographic demonstration of the selectivity of two 1-N-trifluoroethyl benzodiazepines for the BZD-1 receptors in the rat brain., Pharmacol. Biochem. Behav.
    Rho et al., 1997, Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate., J. Pharmacol. Exp. Ther.
    Gonzalez et al., 2009, Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies., J. Pharmacol. Exp. Ther.
    Greenblatt et al., 2001, Divergence of volatile anesthetic effects in inhibitory neurotransmitter receptors., Anesthesiology
    Franks, 2006, Molecular targets underlying general anaesthesia., Br. J. Pharmacol.
    Grasshoff et al., 2006, Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats., Br J Anaesth
    Olsen et al., 2011, GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation., Can J Anaesth
    Roden et al., 2010, Altered GABA(A) receptor subunit expression and pharmacology in human Angelman syndrome cortex., Neurosci. Lett.
    Nutt et al., 2010, Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics., J. Psychopharmacol. (Oxford)
    Hanson et al., 2008, Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different., J. Med. Chem.
    Wadworth AN et al., 1993, Zopiclone. A review of its pharmacological properties and therapeutic efficacy as an hypnotic., Drugs Aging
    Dixon CL et al., 2015, Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity., Br J Pharmacol
    Döble A et al., 1995, The mechanism of action of zopiclone., Eur Psychiatry
    Husain SS et al., 2006, Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels., J Med Chem
    Husain SS et al., 2010, p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels., J Med Chem
    Martin et al., 2009, Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade., Anesthesiology
    Desai et al., 2009, Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity., Anesthesiology
    Pritchett et al., 1990, Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology., J. Neurochem.
    Smith et al., 2001, Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux., Mol. Pharmacol.
    Vlainić et al., 2009, Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam., Neuropharmacology
    Tan KR et al., 2011, Hooked on benzodiazepines: GABAA receptor subtypes and addiction., Trends Neurosci
    Sramka M et al., 1975, Surgical complication of posterior hypothalamotomy., Confin Neurol
    Billard et al., 1988, Selective affinity of the benzodiazepines quazepam and 2-oxo-quazepam for BZ1 binding site and demonstration of 3H-2-oxo-quazepam as a BZ1 selective radioligand., Life Sci.
    Meldrum et al., 1986, Benzodiazepine receptors and their relationship to the treatment of epilepsy., Epilepsia
    Nakatsuka et al., 1985, Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity., Life Sci.
    Franks NP et al., 1994, Molecular and cellular mechanisms of general anaesthesia., Nature
    Qi ZH et al., 2007, Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits., J Biol Chem
    Baburin et al., 2008, Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits., Br. J. Pharmacol.
    Mandrioli et al., 2008, Benzodiazepine metabolism: an analytical perspective., Curr. Drug Metab.
    Derry et al., 2004, Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding., J. Neurochem.
    Terzano et al., 2003, New drugs for insomnia: comparative tolerability of zopiclone, zolpidem and zaleplon., Drug Saf
    Sanger et al., 1999, Discriminative stimulus effects of drugs acting at GABA(A) receptors: differential profiles and receptor selectivity., Pharmacol. Biochem. Behav.
    Patat et al., 2001, Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent., Hum Psychopharmacol
    Barbera et al., 2005, Benefit-risk assessment of zaleplon in the treatment of insomnia., Drug Saf
    Agmo et al., 1998, Interactions between dopamine and GABA in the control of ambulatory activity and neophobia in the mouse., Pharmacol. Biochem. Behav.
    Grech et al., 1993, Pentobarbital-like discriminative stimulus effects of direct GABA agonists in rats., Psychopharmacology (Berl.)
    Fadda et al., 1985, Suppression by progabide of ethanol withdrawal syndrome in rats., Eur. J. Pharmacol.
    Ramerstorfer et al., 2010, The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes., Eur. J. Pharmacol.
    Sanger, 2004, The pharmacology and mechanisms of action of new generation, non-benzodiazepine hypnotic agents., CNS Drugs
    Skerritt et al., 1983, Enhancement of GABA binding by benzodiazepines and related anxiolytics., Eur. J. Pharmacol.
    Zhou BT et al., 2012, Effects of SCN1A and GABA receptor genetic polymorphisms on carbamazepine tolerability and efficacy in Chinese patients with partial seizures: 2-year longitudinal clinical follow-up., CNS Neurosci Ther
    Grasshoff et al., 2008, Depression of spinal network activity by thiopental: shift from phasic to tonic GABA(A) receptor-mediated inhibition., Neuropharmacology
    Sugimura et al., 2002, Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice., Pharmacol. Biochem. Behav.
    Moody et al., 1988, The imidazobenzodiazepine Ro 15-4513 antagonizes methoxyflurane anesthesia., Life Sci.
    Moody et al., 1988, Modulation of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex by inhalation anesthetics., J. Neurochem.
    Krasowski et al., 2000, The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations., Br. J. Pharmacol.
    Braestrup et al., 1978, Pharmacological characterization of benzodiazepine receptors in the brain., Eur. J. Pharmacol.
    Miller et al., 1987, Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam., J. Neurochem.
    Giersch et al., 2010, Atypical behavioural effects of lorazepam: clues to the design of novel therapies?, Pharmacol. Ther.
    Hedera P et al., 2013, Pharmacotherapy of essential tremor., J Cent Nerv Syst Dis
    Cutrer et al., Attenuation by butalbital of capsaicin-induced c-fos-like immunoreactivity in trigeminal nucleus caudalis., Headache
    Nishikawa K et al., 2002, Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations., Neuropharmacology
    Nishikawa K et al., 2003, The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: effects of TM2 mutations in the alpha and beta subunits., Anesthesiology
    Richter et al., 2010, Intrinsic activation of GABA(A) receptors suppresses epileptiform activity in the cerebral cortex of immature mice., Epilepsia
    Law et al., 2008, Gaba receptor insecticide non-competitive antagonists may bind at allosteric modulator sites., Int. J. Neurosci.
    Macdonald et al., 1986, Anticonvulsant drugs: mechanisms of action., Adv Neurol
    Peters et al., 1988, Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids., Br. J. Pharmacol.
    Miller et al., 1988, Acute barbiturate administration increases benzodiazepine receptor binding in vivo., Psychopharmacology (Berl.)
    Kirkness et al., 1986, The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Purification and characterization of the receptor complex from cerebral cortex and cerebellum., Biochem. J.
    Zaugg J et al., 2011, Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice., J Nat Prod
    Podhorna et al., 2000, Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice., Behav Pharmacol
    Tanaka et al., 2008, Comparison of short- and long-acting benzodiazepine-receptor agonists with different receptor selectivity on motor coordination and muscle relaxation following thiopental-induced anesthesia in mice., J. Pharmacol. Sci.
    Smeyatsky et al., 1992, The treatment of sleep disorders., S. Afr. Med. J.
    Skerritt et al., 1983, Interactions of some anaesthetic, convulsant, and anticonvulsant drugs at GABA-benzodiazepine receptor-ionophore complexes in rat brain synaptosomal membranes., Neurochem. Res.
    Tomlin et al., 1999, Preparation of barbiturate optical isomers and their effects on GABA(A) receptors., Anesthesiology
    Earl et al., 2011, Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors., J. Pharmacol. Exp. Ther.
    Davies, 2003, The role of GABAA receptors in mediating the effects of alcohol in the central nervous system., J Psychiatry Neurosci
    Santhakumar et al., 2007, Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition., Alcohol
    Petersen JG et al., 2014, Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists., Eur J Med Chem
    Carta et al., 2006, The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system., Neuropharmacology
    Mascia et al., 2007, Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes., Eur. J. Pharmacol.
    Keppel Hesselink JM, 2017, Phenytoin: a step by step insight into its multiple mechanisms of action-80 years of mechanistic studies in neuropharmacology., J Neurol
    Anzini M et al., 2011, New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds., J Med Chem
  • METHOHEXITAL   GABRA1

    Interaction Score: 4.76

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9014160 17016423 17139284 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • AMOBARBITAL   GABRA1

    Interaction Score: 4.08

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    14579514 10209232 11264449 11752352 10487207


    Sources:
    TTD

  • BARBITAL   GABRA1

    Interaction Score: 3.4

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    14579514 10209232 11264449 10487207


    Sources:
    TTD

  • PROGABIDE   GABRA1

    Interaction Score: 2.38

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    9443561 7831422 17016423 17139284 2985405


    Sources:
    TdgClinicalTrial TEND

  • INDIPLON   GABRA1

    Interaction Score: 2.04

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA receptor alpha-1 subunit positive allosteric modulator
    Direct Interaction yes
    Trial Name Indiplon

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • THIAMYLAL   GABRA1

    Interaction Score: 1.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    18619475 11264449 14579514 10209232 10487207 11900777 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ZALEPLON   GABRA1

    Interaction Score: 1.7

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator
    Trial Name AZ-007, Staccato zaleplon

    PMIDs:
    12608888 10515302 12404558 15783240 17016423 17139284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PICROTOXIN   GABRA1

    Interaction Score: 1.36

    Interaction Types & Directionality:
    antagonist (inhibitory)
    blocker (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752352 17016423 17139284 20491873 18446586


    Sources:
    TdgClinicalTrial TEND TTD

  • BICUCULLINE   GABRA1

    Interaction Score: 1.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17875639


    Sources:
    DTC

  • ZOPICLONE   GABRA1

    Interaction Score: 0.95

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    20303942 15291009 19942638 6135616 18973287


    Sources:
    TdgClinicalTrial TEND

  • SECOBARBITAL   GABRA1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2850060 11264449 2906155 3006661 14579514 10209232 11752352 10487207 17016423 17139284


    Sources:
    TdgClinicalTrial TEND TTD

  • ZOLPIDEM   GABRA1

    Interaction Score: 0.75

    Interaction Types & Directionality:
    agonist (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Trial Name OX-22, zolpidem sublingual,Edluar, Sublinox
    Novel drug target Established target
    Trial Name zolpidem,Intermezzo

    PMIDs:
    2157817 17016423 17139284 11306694 19345234 21353710 1093783


    Sources:
    TdgClinicalTrial TEND TTD

  • HEXOBARBITAL   GABRA1

    Interaction Score: 0.75

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 14579514 10209232 11752352 10487207 10360871 17016423 17139284


    Sources:
    TdgClinicalTrial TEND TTD

  • ISOPIMARIC ACID   GABRA1

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21793559


    Sources:
    DTC

  • BUTETHAL   GABRA1

    Interaction Score: 0.68

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 14579514 10209232 11752352 10487207 17016423 17139284


    Sources:
    TdgClinicalTrial TEND TTD

  • SANDARACOPIMARIC ACID   GABRA1

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21793559


    Sources:
    DTC

  • MEPHOBARBITAL   GABRA1

    Interaction Score: 0.68

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    14579514 10209232 11752352 21194017 11264449 10487207 20692323 17016423 17139284


    Sources:
    TdgClinicalTrial TEND TTD

  • PENTOBARBITAL   GABRA1

    Interaction Score: 0.51

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

    PMIDs:
    11264449 15240758 11605100 14579514 10209232 16866778 11752352 10487207 17016423 17139284 11744750


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ETOMIDATE   GABRA1

    Interaction Score: 0.44

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    16884293 20704351 19809285 17016423 17139284 11752352 19741491


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • THIOPENTAL   GABRA1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    14579514 10209232 18619475 11264449 10487207


    Sources:
    TdgClinicalTrial TEND

  • THIOCOLCHICOSIDE   GABRA1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    16806306 17234181


    Sources:
    TTD

  • BUTALBITAL   GABRA1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11279945 11264449 14579514 10209232 11752352 10487207 17016423 17139284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CHEMBL2170369   GABRA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21751815


    Sources:
    DTC

  • ISONIPECOTIC ACID   GABRA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25038482


    Sources:
    DTC

  • METHARBITAL   GABRA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

    PMIDs:
    11264449 14579514 10209232 11752352 10487207 17016423 17139284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • BUTABARBITAL   GABRA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    10209232 11264449


    Sources:
    TdgClinicalTrial TEND TTD

  • QUAZEPAM   GABRA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

    PMIDs:
    2892106 11752352 17016423 17139284 3017690 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • TALBUTAL   GABRA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

    PMIDs:
    11264449 14579514 10209232 11752352 10487207 17016423 17139284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • HALAZEPAM   GABRA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11752352 17016423 17139284 6738302 2867566 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • METHYPRYLON   GABRA1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name -

    PMIDs:
    17016423 17139284 11752352 1352660


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • NITRAZEPAM   GABRA1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10877119 11752090 11752352 18603831 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial TEND TTD

  • PRAZEPAM   GABRA1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11752352 17016423 17139284 9145922 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ESZOPICLONE   GABRA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name Lunesta

    PMIDs:
    19942638 18973287 8241608 25817320 19698408


    Sources:
    TdgClinicalTrial ChemblInteractions

  • MEPROBAMATE   GABRA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel agonist
    Trial Name -

    PMIDs:
    9067327 19244096 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • PRIMIDONE   GABRA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11264449 14579514 10209232 11752352 10487207 17016423 17139284 24385718


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • METHOXYFLURANE   GABRA1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    2845216 2459308 10683198 11752352 17016423 17139284


    Sources:
    ChemblInteractions TTD

  • CLOTIAZEPAM   GABRA1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18604239 18855614 29950725 23038269


    Sources:
    TdgClinicalTrial TEND

  • ADINAZOLAM   GABRA1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    6320036 6148400 29950725 23038269


    Sources:
    TdgClinicalTrial TEND

  • ZOLPIDEM TARTRATE   GABRA1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CLOBAZAM   GABRA1

    Interaction Score: 0.23

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name Clobazam
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • TEMAZEPAM   GABRA1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    20138190 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • FLUMAZENIL   GABRA1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel allosteric antagonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11864636 17016423 8693922


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ESTAZOLAM   GABRA1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    639854 2889803 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • CLONAZEPAM   GABRA1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Trial Name JZP-8
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • CINOLAZEPAM   GABRA1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9145922 29950725 23038269


    Sources:
    TdgClinicalTrial TEND

  • FLURAZEPAM   GABRA1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial TEND

  • CHLORDIAZEPOXIDE   GABRA1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    6135616 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • LORAZEPAM   GABRA1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • OXAZEPAM   GABRA1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DIAZEPAM   GABRA1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name diazepam rectal gel

    PMIDs:
    15009644 11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • CHEMBL1518572   GABRA1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ISOFLURANE   GABRA1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    20826568 17016423 17139284 20097266


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PHENOBARBITAL   GABRA1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 14579514 2871724 10209232 10487207 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • BROMAZEPAM   GABRA1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456 29950725 23038269


    Sources:
    TdgClinicalTrial TEND

  • TRIAZOLAM   GABRA1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    allosteric modulator
    potentiator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name ARX-03, sufentanil + triazolam NanoTab

    PMIDs:
    11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ALPRAZOLAM   GABRA1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    14978513 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • TOPIRAMATE   GABRA1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes
    Trial Name topiramate controlled release,Trokesa

    PMIDs:
    19417176 19998575 17016423 17139284 10768303 25101297


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • BREXANOLONE   GABRA1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CLORAZEPIC ACID   GABRA1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial TEND

  • ENFLURANE   GABRA1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator

    PMIDs:
    11465594 16402123 16973644


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ETHCHLORVYNOL   GABRA1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    1585214


    Sources:
    ChemblInteractions TTD

  • SEVOFLURANE   GABRA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name -

    PMIDs:
    17016423 17139284 7509043


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • HALOTHANE   GABRA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    positive modulator (activating)
    other/unknown

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    17016423 17139284 11897112 12960553


    Sources:
    ChemblInteractions

  • FLUDIAZEPAM   GABRA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2857046


    Sources:
    TdgClinicalTrial TEND

  • DESFLURANE   GABRA1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    11752090 18384456


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • MIDAZOLAM   GABRA1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11752090 18384456 29950725 23038269


    Sources:
    TdgClinicalTrial TEND

  • GABOXADOL   GABRA1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; agonist GABA site agonist
    Direct Interaction yes
    Trial Name gaboxadol

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • AZIETOMIDATE   GABRA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16884293


    Sources:
    DTC

  • GLUTETHIMIDE   GABRA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    positive modulator (activating)
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    6318143


    Sources:
    ChemblInteractions

  • GANAXOLONE   GABRA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Ganaxolone
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • RESEQUINIL   GABRA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; benzodiazepine site inverse agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LOREDIPLON   GABRA1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; benzodiazepine site positive allosteric modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ADIPIPLON   GABRA1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Trial Name NG2-73
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ALCOHOL   GABRA1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    21262851 12921221 11752352 17591544 17016423 17139284


    Sources:
    TTD

  • TRICLOFOS SODIUM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CLORAZEPATE DIPOTASSIUM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METHOHEXITAL SODIUM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENTOBARBITAL SODIUM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUTABARBITAL SODIUM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SECOBARBITAL SODIUM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PF-06372865   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHLORDIAZEPOXIDE HYDROCHLORIDE   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THIOPENTAL SODIUM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MIDAZOLAM HYDROCHLORIDE   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THIAMYLAL SODIUM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OCINAPLON   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Trial Name ocinaplon
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • REMIMAZOLAM   GABRA1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name CNS-7056
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PHENYTOIN   GABRA1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28349209


    Sources:
    PharmGKB

  • CARBAMAZEPINE   GABRA1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22591328


    Sources:
    PharmGKB

  • ACAMPROSATE CALCIUM   GABRA1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPOFOL   GABRA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000022355

    • Version: 101_38

    Alternate Names:
    GABRA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000022355

    • Version: 26-July-2011

    Alternate Names:
    GAMMA-AMINOBUTYRIC-ACID RECEPTOR ALPHA-1 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P14867] Description
    GABRA1 Display Id
    ENSG00000022355 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P14867

    • Version: 01-August-2011

    Alternate Names:
    2554 Entrez Gene Id
    GBRA1_HUMAN Uniprot Id
    ENSG00000022355 Ensembl Gene Id

    Gene Info:
    Target Subclass Channels
    Target Subclass Ligand_gated_ion_channels
    Target Subclass cys-loop

    Publications:

  • HopkinsGroom: P14867

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000022355 Ensembl Gene Id
    GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 Uniprot Protein Name
    2554 Entrez Gene Id

    Gene Info:
    Human Readable Name ION CHANNEL
    Interpro Short Name Neur_chan_lig-bd
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P14867

    • Version: January-2014

    Alternate Names:
    GABRA1 Gene Symbol
    GABRD Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.9

    Publications:

  • PharmGKB: GABRA1

    • Version: 18-August-2020

    Alternate Names:
    PA28489 PharmGKB ID

    Gene Info:

    Publications:
    Zhou BT et al., 2012, Effects of SCN1A and GABA receptor genetic polymorphisms on carbamazepine tolerability and efficacy in Chinese patients with partial seizures: 2-year longitudinal clinical follow-up., CNS Neurosci Ther

  • DTC: GABRA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Husain SS et al., 2006, Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels., J Med Chem
    Anzini M et al., 2011, New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds., J Med Chem
    Zaugg J et al., 2011, Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice., J Nat Prod

  • HingoraniCasas: ENSG00000022355

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000022355 Gene Symbol
    GABRA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GABRA1

    • Version: chembl_23

    Alternate Names:
    GABRA1 GENE_SYMBOL
    Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT
    GABA(A) receptor subunit alpha-1 UNIPROT

    Gene Info:

    Publications:

  • TTD: GABA(A) receptor alpha-1

    • Version: 2020.06.01

    Alternate Names:
    GABRA1 TTD Gene Abbreviation
    T51487 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: GABRA1

    • Version: 01-February-2022

    Alternate Names:
    Gamma-aminobutyric acid receptor subunit alpha-1 Gene Name
    P14867 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21