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G6PD Gene Record

  • Summary
  • Interactions
  • Claims
  • G6PD 2539 Druggable Genome

    Alternate Names:

    2539
    GLUCOSE-6-PHOSPHATE DEHYDROGENASE
    G6PD
    G6PD1
    305900
    4057
    ENSG00000160211
    OTTHUMG00000024237
    PA28469
    P11413
    T63484
    Glucose-6-phosphate 1-dehydrogenase

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Tishler M et al., 1983, Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency., Acta Haematol
    Mercieca JE et al., 1982, Acute hemolytic anaemia due to phenazopyridine hydrochloride in G-6-PD deficient subject., Lancet
    Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol
    Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf
    Owens RE et al., 2016, Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency., J Clin Rheumatol
    Geraldino-Pardilla L et al., 2014, Methaemoglobinaemia and haemolysis following pegloticase infusion for refractory gout in a patient with a falsely negative glucose-6-phosphate dehydrogenase deficiency result., Rheumatology (Oxford)
    Kaliman et al., 1999, Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress., Biochemistry Mosc.
    Beydemir et al., 2002, Purification and characterization of glucose 6-phosphate dehydrogenase from sheep erythrocytes and inhibitory effects of some antibiotics on enzyme activity., J Enzyme Inhib Med Chem
    Chan et al., 1975, Letter: Glucose-6-phosphate dehydrogenase deficiency and co-trimoxazole., Lancet
    Janakiraman N et al., 1978, Hemolysis during BAL chelation therapy for high blood lead levels in two G6PD deficient children., Clin Pediatr (Phila)
    Marsicano AR Jr et al., 1973, Fatal hemolysis from mafenide treatment of burns in a patient with glucose-6-phosphate dehydrogenase deficiency. Case report., Plast Reconstr Surg
    Ozdemir et al., 2006, In vitro effects of some drugs on human red blood cell glucose-6-phosphate dehydrogenase enzyme activity., J Enzyme Inhib Med Chem
    Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol
    Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol
    Pui CH et al., 1997, Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies., Leukemia
    Akande M et al., 2017, Rasburicase-induced Hemolytic Anemia in an Adolescent With Unknown Glucose-6-Phosphate Dehydrogenase Deficiency., J Pediatr Pharmacol Ther
    Cooling L, 2017, Brisk clinical response to erythrocytapheresis in a G6PD-deficient patient with rasburicase-induced methemoglobinemia., J Clin Apher
    Montgomery KW et al., 2017, A perfect storm: Tumor lysis syndrome with rasburicase-induced methemoglobinemia in a G6PD deficient adult., J Clin Apher
    Oluwasanjo A et al., 2015, Rasburicase-induced methaemoglobinaemia and G6PD deficiency in an unusual suspect., Br J Haematol
    Zhang B et al., 2014, Tumor lysis syndrome and acute anemia in an African-American man with chronic lymphocytic leukemia., Oxf Med Case Reports
    Bontant T et al., 2014, Methaemoglobinaemia in a G6PD-deficient child treated with rasburicase., BMJ Case Rep
    McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
    Relling MV et al., 2014, Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype., Clin Pharmacol Ther
    Roberts DA et al., 2015, Rasburicase-induced methemoglobinemia in two African-American female patients: an under-recognized and continued problem., Eur J Haematol
    Pansy J et al., 2014, Cyanosis in a male Nigerian infant with acute kidney injury: answers., Pediatr Nephrol
    Cheah CY et al., 2013, Rasburicase causing severe oxidative hemolysis and methemoglobinemia in a patient with previously unrecognized glucose-6-phosphate dehydrogenase deficiency., Acta Haematol
    Zaramella P et al., 2013, Lethal effect of a single dose of rasburicase in a preterm newborn infant., Pediatrics
    Sonbol MB et al., 2013, Methemoglobinemia and hemolysis in a patient with G6PD deficiency treated with rasburicase., Am J Hematol
    Ng JS et al., 2012, Methemoglobinemia induced by rasburicase in a pediatric patient: a case report and literature review., J Oncol Pharm Pract
    Vadhan-Raj S et al., 2012, A randomized trial of a single-dose rasburicase versus five-daily doses in patients at risk for tumor lysis syndrome., Ann Oncol
    Bain BJ, 2010, A ghostly presence-G6PD deficiency., Am J Hematol
    Ducros J et al., 1991, Hemolytic anemia due to G6PD deficiency and urate oxidase in a kidney-transplant patient., Clin Nephrol
    Joly P et al., 2009, [A severe G6PD deficiency revealed during a chemotherapy protocol including rasburicase]., Ann Biol Clin (Paris)
    Bhat P et al., 2008, Exchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient., Pediatr Blood Cancer
    Borinstein SC et al., 2008, Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia., Pediatr Blood Cancer
    Browning LA et al., 2005, Hemolysis and methemoglobinemia secondary to rasburicase administration., Ann Pharmacother
    Bosly A et al., 2003, Rasburicase (recombinant urate oxidase) for the management of hyperuricemia in patients with cancer: report of an international compassionate use study., Cancer
    Patte C et al., 2002, Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Française d'Oncologie Pédiatrique LMB89 protocol., Ann Oncol
    Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.
    Pritchard JA et al., 1965, Severe anemia with hemolysis and megaloblastic erythropoiesis. A reaction to nitrofurantoin administered during pregnancy., JAMA
    Syzdół P et al., 1991, [Recurrent acute renal failure during the course of hemolytic crisis in a patient with glucose-6-phosphate dehydrogenase deficiency]., Pol Tyg Lek
    Lavelle KJ et al., 1976, Hyperlactatemia and hemolysis in G6PD deficiency after nitrofurantoin ingestion., Am J Med Sci
    Cherian et al., 1989, Effect of busulfan on crystalline lens--glutathione, glutathione reductase and glucose-6-phosphate dehydrogenase., Indian J. Exp. Biol.
    Cohen SM et al., 1968, Ulcerative colitis and erythrocyte G6PD deficiency. Salicylazosulfapyridine-provoked hemolysis., JAMA
    Srivatsa et al., 2003, Does nimesulide induce haemolysis in glucose-6-phosphate dehydrogenase deficiency?, Acta Paediatr.
    Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.
    Alloueche A et al., 2004, Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial., Lancet
    Sulo J et al., 2002, Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial., Lancet
    Luzzatto L, 2010, The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics., Lancet
    Altikat et al., In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase., Pol J Pharmacol
    Carette C et al., 2011, Diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency: from one crisis to another., Diabetes Metab
    Vinzio S et al., 2004, Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency., Diabetes Res Clin Pract
    Meloni G et al., 1996, Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM., Br J Haematol
    Yilmaz et al., 2004, The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats., Pharmacol. Res.
    Tungsiripat M et al., 2008, Prevalence and significance of G6PD deficiency in patients of an urban HIV clinic., J Int Assoc Physicians AIDS Care (Chic)
    Sansone S et al., 2010, Ciprofloxacin-induced acute haemolytic anaemia in a patient with glucose-6-phosphate dehydrogenase Mediterranean deficiency: a case report., Ann Hematol
    Dash S et al., 1977, Combined G-6PD and 6-PGD deficiency in a Hindu boy., Acta Haematol
    Ali NA et al., 1999, Haemolytic potential of three chemotherapeutic agents and aspirin in glucose-6-phosphate dehydrogenase deficiency., East Mediterr Health J
    Amitai Y et al., 1996, Glucose-6-phosphate dehydrogenase deficiency severely restricts the biotransformation of daunorubicin in human erythrocytes., J Lab Clin Med
  • RASBURICASE   G6PD

    Interaction Score: 4.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9369411 29290749 28370399 27119769 26033222 25988058 25115783 24915143 24787449 24750455 24372186 23989394 23860572 23209099 22573495 22190578 22015451 20701405 20196170 2019023 19654083 18561168 17387701 16204390 12942574 12075750


    Sources:
    PharmGKB FDA

  • PHENAZOPYRIDINE   G6PD

    Interaction Score: 4.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6410650 6125724 24372186 20701405


    Sources:
    PharmGKB

  • PEGLOTICASE   G6PD

    Interaction Score: 3.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26906307 25224415


    Sources:
    PharmGKB FDA

  • MAFENIDE   G6PD

    Interaction Score: 2.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4722683


    Sources:
    PharmGKB FDA

  • SULFANILAMIDE   G6PD

    Interaction Score: 1.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10793824


    Sources:
    PharmGKB

  • CHLORPROGUANIL   G6PD

    Interaction Score: 1.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15183620 12387962 20599264


    Sources:
    PharmGKB

  • SUCCIMER   G6PD

    Interaction Score: 1.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • CO-TRIMOXAZOLE   G6PD

    Interaction Score: 1.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    46571


    Sources:
    NCI

  • SULFADIAZINE   G6PD

    Interaction Score: 1.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24372186


    Sources:
    PharmGKB FDA

  • ARTICAINE   G6PD

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Articaine,Epinephrine

    PMIDs:
    None found


    Sources:
    FDA

  • METABUTETHAMINE   G6PD

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SITAMAQUINE   G6PD

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • TAFENOQUINE   G6PD

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • DAPSONE   G6PD

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24372186 18349424 15183620 12387962 20701405 20599264


    Sources:
    PharmGKB FDA

  • NITROFURANTOIN   G6PD

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    5897424 20701405 1669155 12659


    Sources:
    PharmGKB FDA

  • MOXIFLOXACIN   G6PD

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ROPIVACAINE   G6PD

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • EPIANDROSTERONE   G6PD

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHLOROPROCAINE   G6PD

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • GLYBURIDE   G6PD

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21147013 15126005 8562390 20701405


    Sources:
    PharmGKB FDA

  • DIMERCAPROL   G6PD

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    417891


    Sources:
    PharmGKB

  • PENICILLIN G POTASSIUM   G6PD

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12530481


    Sources:
    NCI

  • NORFLOXACIN   G6PD

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MEPIVACAINE   G6PD

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TOLBUTAMIDE   G6PD

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • GLIPIZIDE   G6PD

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TOLAZAMIDE   G6PD

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • SULFISOXAZOLE   G6PD

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Erythromycin,Sulfisoxazole

    PMIDs:
    None found


    Sources:
    FDA

  • QUININE   G6PD

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    407765


    Sources:
    PharmGKB

  • GLIMEPIRIDE   G6PD

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • NICORANDIL   G6PD

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PERINDOPRIL   G6PD

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CIPROFLOXACIN   G6PD

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20127091


    Sources:
    PharmGKB

  • AMODIAQUINE   G6PD

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • OXYMETAZOLINE   G6PD

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Oxymetazoline,Tetracaine

    PMIDs:
    None found


    Sources:
    FDA

  • SULFAMETHOXAZOLE   G6PD

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Sulfamethoxazole,Trimethoprim

    PMIDs:
    None found


    Sources:
    FDA

  • CARMUSTINE   G6PD

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    539595


    Sources:
    PharmGKB

  • HYDROXYCHLOROQUINE   G6PD

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • CHLORPROPAMIDE   G6PD

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • PRILOCAINE   G6PD

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Lidocaine,Prilocaine

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • GLICLAZIDE   G6PD

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • NIMESULIDE   G6PD

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12839301


    Sources:
    NCI

  • CEFTRIAXONE   G6PD

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • METOCLOPRAMIDE   G6PD

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • ARTESUNATE   G6PD

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PROBENECID   G6PD

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • SULFASALAZINE   G6PD

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4386139


    Sources:
    PharmGKB FDA

  • PRIMAQUINE   G6PD

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • PROPRANOLOL   G6PD

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10395986


    Sources:
    NCI

  • BUSULFAN   G6PD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2635153


    Sources:
    NCI

  • FLUTAMIDE   G6PD

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • DABRAFENIB   G6PD

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TRIMETHOPRIM   G6PD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Sulfamethoxazole,Trimethoprim

    PMIDs:
    None found


    Sources:
    FDA

  • TETRACAINE   G6PD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Lidocaine,Tetracaine
    Combination therapy Oxymetazoline,Tetracaine

    PMIDs:
    None found


    Sources:
    FDA

  • OFLOXACIN   G6PD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CHLOROQUINE   G6PD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • TRIAMCINOLONE   G6PD

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1197440


    Sources:
    NCI

  • PREDNISOLONE   G6PD

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16324786


    Sources:
    NCI

  • PROTOPORPHYRIN   G6PD

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9267885


    Sources:
    NCI

  • DIAZEPAM   G6PD

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12020046


    Sources:
    NCI

  • PIOGLITAZONE   G6PD

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LIDOCAINE   G6PD

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Lidocaine,Prilocaine
    Combination therapy Lidocaine,Tetracaine

    PMIDs:
    None found


    Sources:
    FDA

  • OMEPRAZOLE   G6PD

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16570509


    Sources:
    NCI

  • PRASTERONE   G6PD

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ERYTHROMYCIN   G6PD

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Erythromycin,Sulfisoxazole

    PMIDs:
    None found


    Sources:
    FDA

  • TRAMETINIB   G6PD

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • EPINEPHRINE   G6PD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Articaine,Epinephrine

    PMIDs:
    None found


    Sources:
    FDA

  • DAUNORUBICIN   G6PD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8648264


    Sources:
    PharmGKB

  • EBSELEN   G6PD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXORUBICIN   G6PD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    539595


    Sources:
    PharmGKB

  • CISPLATIN   G6PD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15225672


    Sources:
    NCI

  • Ensembl: ENSG00000160211

    • Version: 101_38

    Alternate Names:
    G6PD Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: G6PD

    • Version: 18-August-2020

    Alternate Names:
    PA28469 PharmGKB ID

    Gene Info:

    Publications:
    Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol
    Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol
    Zhang P et al., 2013, An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines., Am J Trop Med Hyg

  • NCI: G6PD

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol
    Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.
    Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.

  • HingoraniCasas: ENSG00000160211

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000160211 Gene Symbol
    G6PD Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: G6PD

    • Version: 19.3

    Alternate Names:
    ENSG00000160211 Ensembl Gene ID
    G6PD1 Human Protein Atlas Gene Synonym
    Glucose-6-phosphate dehydrogenase Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Tempus: G6PD

    • Version: 11-November-2018

    Alternate Names:
    G6PD Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Glucose-6-phosphate dehydrogenase

    • Version: 2020.06.01

    Alternate Names:
    G6PD TTD Gene Abbreviation
    T63484 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: G6PD

    • Version: 01-February-2022

    Alternate Names:
    Glucose-6-phosphate 1-dehydrogenase Gene Name
    P11413 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • DTC: G6PD

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • FDA: G6PD

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21