DGIdb - G6PD Gene Record

G6PD 2539 Druggable Genome

Alternate Names:

2539
GLUCOSE-6-PHOSPHATE DEHYDROGENASE
G6PD
G6PD1
305900
4057
ENSG00000160211
OTTHUMG00000024237
PA28469
BE0001089
P11413
T63484
Glucose-6-phosphate 1-dehydrogenase

Gene Info:

Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol
Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf
Mercieca JE et al., 1982, Acute hemolytic anaemia due to phenazopyridine hydrochloride in G-6-PD deficient subject., Lancet
Tishler M et al., 1983, Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency., Acta Haematol
Owens RE et al., 2016, Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency., J Clin Rheumatol
Geraldino-Pardilla L et al., 2014, Methaemoglobinaemia and haemolysis following pegloticase infusion for refractory gout in a patient with a falsely negative glucose-6-phosphate dehydrogenase deficiency result., Rheumatology (Oxford)
Kaliman et al., 1999, Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress., Biochemistry Mosc.
Beydemir et al., 2002, Purification and characterization of glucose 6-phosphate dehydrogenase from sheep erythrocytes and inhibitory effects of some antibiotics on enzyme activity., J Enzyme Inhib Med Chem
Chan et al., 1975, Letter: Glucose-6-phosphate dehydrogenase deficiency and co-trimoxazole., Lancet
Janakiraman N et al., 1978, Hemolysis during BAL chelation therapy for high blood lead levels in two G6PD deficient children., Clin Pediatr (Phila)
Marsicano AR Jr et al., 1973, Fatal hemolysis from mafenide treatment of burns in a patient with glucose-6-phosphate dehydrogenase deficiency. Case report., Plast Reconstr Surg
Ozdemir et al., 2006, In vitro effects of some drugs on human red blood cell glucose-6-phosphate dehydrogenase enzyme activity., J Enzyme Inhib Med Chem
Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol
Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol
Borinstein SC et al., 2008, Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia., Pediatr Blood Cancer
Pansy J et al., 2014, Cyanosis in a male Nigerian infant with acute kidney injury: answers., Pediatr Nephrol
Bain BJ, 2010, A ghostly presence-G6PD deficiency., Am J Hematol
Cooling L, 2017, Brisk clinical response to erythrocytapheresis in a G6PD-deficient patient with rasburicase-induced methemoglobinemia., J Clin Apher
Zaramella P et al., 2013, Lethal effect of a single dose of rasburicase in a preterm newborn infant., Pediatrics
Relling MV et al., 2014, Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype., Clin Pharmacol Ther
Montgomery KW et al., 2017, A perfect storm: Tumor lysis syndrome with rasburicase-induced methemoglobinemia in a G6PD deficient adult., J Clin Apher
Patte C et al., 2002, Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Française d'Oncologie Pédiatrique LMB89 protocol., Ann Oncol
Bosly A et al., 2003, Rasburicase (recombinant urate oxidase) for the management of hyperuricemia in patients with cancer: report of an international compassionate use study., Cancer
Cheah CY et al., 2013, Rasburicase causing severe oxidative hemolysis and methemoglobinemia in a patient with previously unrecognized glucose-6-phosphate dehydrogenase deficiency., Acta Haematol
Akande M et al., 2017, Rasburicase-induced Hemolytic Anemia in an Adolescent With Unknown Glucose-6-Phosphate Dehydrogenase Deficiency., J Pediatr Pharmacol Ther
Roberts DA et al., 2015, Rasburicase-induced methemoglobinemia in two African-American female patients: an under-recognized and continued problem., Eur J Haematol
Ducros J et al., 1991, Hemolytic anemia due to G6PD deficiency and urate oxidase in a kidney-transplant patient., Clin Nephrol
Zhang B et al., 2014, Tumor lysis syndrome and acute anemia in an African-American man with chronic lymphocytic leukemia., Oxf Med Case Reports
Sonbol MB et al., 2013, Methemoglobinemia and hemolysis in a patient with G6PD deficiency treated with rasburicase., Am J Hematol
Oluwasanjo A et al., 2015, Rasburicase-induced methaemoglobinaemia and G6PD deficiency in an unusual suspect., Br J Haematol
Pui CH et al., 1997, Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies., Leukemia
Joly P et al., 2009, [A severe G6PD deficiency revealed during a chemotherapy protocol including rasburicase]., Ann Biol Clin (Paris)
Browning LA et al., 2005, Hemolysis and methemoglobinemia secondary to rasburicase administration., Ann Pharmacother
Ng JS et al., 2012, Methemoglobinemia induced by rasburicase in a pediatric patient: a case report and literature review., J Oncol Pharm Pract
Bhat P et al., 2008, Exchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient., Pediatr Blood Cancer
Vadhan-Raj S et al., 2012, A randomized trial of a single-dose rasburicase versus five-daily doses in patients at risk for tumor lysis syndrome., Ann Oncol
McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
Bontant T et al., 2014, Methaemoglobinaemia in a G6PD-deficient child treated with rasburicase., BMJ Case Rep
Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.
Pritchard JA et al., 1965, Severe anemia with hemolysis and megaloblastic erythropoiesis. A reaction to nitrofurantoin administered during pregnancy., JAMA
Lavelle KJ et al., 1976, Hyperlactatemia and hemolysis in G6PD deficiency after nitrofurantoin ingestion., Am J Med Sci
Syzdół P et al., 1991, [Recurrent acute renal failure during the course of hemolytic crisis in a patient with glucose-6-phosphate dehydrogenase deficiency]., Pol Tyg Lek
Cherian et al., 1989, Effect of busulfan on crystalline lens--glutathione, glutathione reductase and glucose-6-phosphate dehydrogenase., Indian J. Exp. Biol.
Cohen SM et al., 1968, Ulcerative colitis and erythrocyte G6PD deficiency. Salicylazosulfapyridine-provoked hemolysis., JAMA
Srivatsa et al., 2003, Does nimesulide induce haemolysis in glucose-6-phosphate dehydrogenase deficiency?, Acta Paediatr.
Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.
Sulo J et al., 2002, Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial., Lancet
Luzzatto L, 2010, The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics., Lancet
Alloueche A et al., 2004, Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial., Lancet
Altikat et al., In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase., Pol J Pharmacol
Carette C et al., 2011, Diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency: from one crisis to another., Diabetes Metab
Vinzio S et al., 2004, Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency., Diabetes Res Clin Pract
Meloni G et al., 1996, Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM., Br J Haematol
Yilmaz et al., 2004, The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats., Pharmacol. Res.
Tungsiripat M et al., 2008, Prevalence and significance of G6PD deficiency in patients of an urban HIV clinic., J Int Assoc Physicians AIDS Care (Chic)
Sansone S et al., 2010, Ciprofloxacin-induced acute haemolytic anaemia in a patient with glucose-6-phosphate dehydrogenase Mediterranean deficiency: a case report., Ann Hematol
Dash S et al., 1977, Combined G-6PD and 6-PGD deficiency in a Hindu boy., Acta Haematol
Ali NA et al., 1999, Haemolytic potential of three chemotherapeutic agents and aspirin in glucose-6-phosphate dehydrogenase deficiency., East Mediterr Health J
Amitai Y et al., 1996, Glucose-6-phosphate dehydrogenase deficiency severely restricts the biotransformation of daunorubicin in human erythrocytes., J Lab Clin Med
Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Ribaya JD et al., 1979, Interrelationships in rats among dietary vitamin B6, glycine and hydroxyproline. Effects of oxalate, glyoxylate, glycolate, and glycine on liver enzymes., J Nutr

RASBURICASE G6PD

Interaction Score: 4.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17387701 23989394 20196170 28370399 23209099 24787449 27119769 12075750 24372186 20701405 12942574 23860572 29290749 24750455 2019023 25988058 22573495 26033222 9369411 19654083 16204390 22190578 18561168 22015451 24915143 25115783

Sources:
FDA PharmGKB
PEGLOTICASE G6PD

Interaction Score: 3.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26906307 25224415

Sources:
FDA PharmGKB
PHENAZOPYRIDINE G6PD

Interaction Score: 1.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24372186 20701405 6125724 6410650

Sources:
PharmGKB
GLYCOLIC ACID G6PD

Interaction Score: 1.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
430210

Sources:
DrugBank
SULFANILAMIDE G6PD

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10793824

Sources:
PharmGKB
CHLORPROGUANIL G6PD

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12387962 20599264 15183620

Sources:
PharmGKB
SUCCIMER G6PD

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
CO-TRIMOXAZOLE G6PD

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
46571

Sources:
NCI
MAFENIDE G6PD

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4722683

Sources:
FDA PharmGKB
SULFADIAZINE G6PD

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24372186

Sources:
FDA PharmGKB
16.ALPHA.-BROMOEPIANDROSTERONE G6PD

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ARTICAINE G6PD

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Articaine,Epinephrine

PMIDs:
None found

Sources:
FDA
METABUTETHAMINE G6PD

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SITAMAQUINE G6PD

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
TAFENOQUINE G6PD

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
DAPSONE G6PD

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12387962 20599264 18349424 24372186 20701405 15183620

Sources:
FDA PharmGKB
NITROFURANTOIN G6PD

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
5897424 20701405 12659 1669155

Sources:
FDA PharmGKB
EPIANDROSTERONE G6PD

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ROPIVACAINE G6PD

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
CHLOROPROCAINE G6PD

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
PENICILLIN G POTASSIUM G6PD

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12530481

Sources:
NCI
MOXIFLOXACIN G6PD

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DIMERCAPROL G6PD

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
417891

Sources:
PharmGKB
MEPIVACAINE G6PD

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
TOLAZAMIDE G6PD

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
GLYBURIDE G6PD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21147013 20701405 15126005 8562390

Sources:
FDA PharmGKB
SULFISOXAZOLE G6PD

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Erythromycin,Sulfisoxazole

PMIDs:
None found

Sources:
FDA
TOLBUTAMIDE G6PD

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
GLIMEPIRIDE G6PD

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
NORFLOXACIN G6PD

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
GLIPIZIDE G6PD

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
AMODIAQUINE G6PD

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
NICORANDIL G6PD

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PERINDOPRIL G6PD

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SULFAMETHOXAZOLE G6PD

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sulfamethoxazole,Trimethoprim

PMIDs:
None found

Sources:
FDA
CARMUSTINE G6PD

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
539595

Sources:
PharmGKB
CIPROFLOXACIN G6PD

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20127091

Sources:
PharmGKB
CHLORPROPAMIDE G6PD

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
PRILOCAINE G6PD

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Prilocaine

PMIDs:
None found

Sources:
FDA PharmGKB
HYDROXYCHLOROQUINE G6PD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
QUININE G6PD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
407765

Sources:
PharmGKB
GLICLAZIDE G6PD

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ARTESUNATE G6PD

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METOCLOPRAMIDE G6PD

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
NIMESULIDE G6PD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12839301

Sources:
NCI
DABRAFENIB G6PD

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family BRAF inhibitor

Alteration G6PD:.

Alteration G6PD:S218F

PMIDs:
None found

Sources:
FDA PharmGKB CGI
CEFTRIAXONE G6PD

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
BUSULFAN G6PD

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2635153

Sources:
NCI
PROPRANOLOL G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10395986

Sources:
NCI
SODIUM BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
SULFASALAZINE G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4386139

Sources:
FDA PharmGKB
PRIMAQUINE G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
FLUTAMIDE G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
PROBENECID G6PD

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
TRIMETHOPRIM G6PD

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sulfamethoxazole,Trimethoprim

PMIDs:
None found

Sources:
FDA
TRIAMCINOLONE G6PD

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1197440

Sources:
NCI
OFLOXACIN G6PD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
OXYMETAZOLINE G6PD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Oxymetazoline,Tetracaine

PMIDs:
None found

Sources:
FDA
PREDNISOLONE G6PD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16324786

Sources:
NCI
TETRACAINE G6PD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Tetracaine

Combination therapy Oxymetazoline,Tetracaine

PMIDs:
None found

Sources:
FDA
PROTOPORPHYRIN G6PD

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9267885

Sources:
NCI
DIAZEPAM G6PD

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12020046

Sources:
NCI
OMEPRAZOLE G6PD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16570509

Sources:
NCI
PIOGLITAZONE G6PD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CHLOROQUINE G6PD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
LIDOCAINE G6PD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Prilocaine

Combination therapy Lidocaine,Tetracaine

PMIDs:
None found

Sources:
FDA
ERYTHROMYCIN G6PD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Erythromycin,Sulfisoxazole

PMIDs:
None found

Sources:
FDA
TRAMETINIB G6PD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
PRASTERONE G6PD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
EPINEPHRINE G6PD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Articaine,Epinephrine

PMIDs:
None found

Sources:
FDA
DAUNORUBICIN G6PD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8648264

Sources:
PharmGKB
EBSELEN G6PD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ARTENIMOL G6PD

Interaction Score: 0.02

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
26340163

Sources:
DrugBank
DOXORUBICIN G6PD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
539595

Sources:
PharmGKB
CISPLATIN G6PD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15225672

Sources:
NCI

Ensembl: ENSG00000160211
- Version: 101_38
Alternate Names:

G6PD Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: G6PD

Version: 18-August-2020

Alternate Names:

PA28469 PharmGKB ID

Gene Info:

Publications:

Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol

Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol

Zhang P et al., 2013, An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines., Am J Trop Med Hyg

DrugBank: BE0001089

Version: 5.1.7

Alternate Names:

G6PD DrugBank Gene Name

P11413 UniProt Accession

2539 Entrez Gene Id

Gene Info:

Publications:

Ribaya JD et al., 1979, Interrelationships in rats among dietary vitamin B6, glycine and hydroxyproline. Effects of oxalate, glyoxylate, glycolate, and glycine on liver enzymes., J Nutr

Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

NCI: G6PD

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol

Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.

Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.

HingoraniCasas: ENSG00000160211
- Version: 31-May-2017
Alternate Names:

ENSG00000160211 Gene Symbol

G6PD Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: G6PD
- Version: 19.3
Alternate Names:

ENSG00000160211 Ensembl Gene ID

G6PD1 Human Protein Atlas Gene Synonym

Glucose-6-phosphate dehydrogenase Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: G6PD
- Version: 03-September-2020
Alternate Names:

Glucose-6-phosphate 1-dehydrogenase Gene Name

P11413 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: G6PD
- Version: 11-November-2018
Alternate Names:

G6PD Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Glucose-6-phosphate dehydrogenase
- Version: 2020.06.01
Alternate Names:

G6PD TTD Gene Abbreviation

T63484 TTD Target ID

Gene Info:

Publications:
CGI: G6PD
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:
DTC: G6PD
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:
FDA: G6PD
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Drug family	BRAF inhibitor
Alteration	G6PD:.
Alteration	G6PD:S218F

Combination therapy	Lidocaine,Tetracaine
Combination therapy	Oxymetazoline,Tetracaine

Combination therapy	Lidocaine,Prilocaine
Combination therapy	Lidocaine,Tetracaine

G6PD	DrugBank Gene Name
P11413	UniProt Accession
2539	Entrez Gene Id

ENSG00000160211	Ensembl Gene ID
G6PD1	Human Protein Atlas Gene Synonym
Glucose-6-phosphate dehydrogenase	Human Protein Atlas Gene Description

Glucose-6-phosphate 1-dehydrogenase	Gene Name
P11413	UniProt ID

G6PD Gene Record

G6PD 2539 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17387701 23989394 20196170 28370399 23209099 24787449 27119769 12075750 24372186 20701405 12942574 23860572 29290749 24750455 2019023 25988058 22573495 26033222 9369411 19654083 16204390 22190578 18561168 22015451 24915143 25115783

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26906307 25224415

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24372186 20701405 6125724 6410650

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 430210

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10793824

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12387962 20599264 15183620

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 46571

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4722683

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24372186

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Articaine,Epinephrine

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12387962 20599264 18349424 24372186 20701405 15183620

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 5897424 20701405 12659 1669155

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17387701 23989394 20196170 28370399 23209099 24787449 27119769 12075750 24372186 20701405 12942574 23860572 29290749 24750455 2019023 25988058 22573495 26033222 9369411 19654083 16204390 22190578 18561168 22015451 24915143 25115783

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26906307 25224415

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24372186 20701405 6125724 6410650

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
430210

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10793824

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12387962 20599264 15183620

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
46571

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
4722683

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24372186

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Articaine,Epinephrine

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12387962 20599264 18349424 24372186 20701405 15183620

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
5897424 20701405 12659 1669155

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12530481

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
417891

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21147013 20701405 15126005 8562390

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a