DGIdb - G6PD Gene Record

G6PD 2539 Druggable Genome

Alternate Names:

2539
GLUCOSE-6-PHOSPHATE DEHYDROGENASE
G6PD
G6PD1
305900
4057
ENSG00000160211
OTTHUMG00000024237
PA28469
BE0001089
P11413
T63484
Glucose-6-phosphate 1-dehydrogenase

Gene Info:

Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Tishler M et al., 1983, Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency., Acta Haematol
Mercieca JE et al., 1982, Acute hemolytic anaemia due to phenazopyridine hydrochloride in G-6-PD deficient subject., Lancet
Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol
Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf
Owens RE et al., 2016, Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency., J Clin Rheumatol
Geraldino-Pardilla L et al., 2014, Methaemoglobinaemia and haemolysis following pegloticase infusion for refractory gout in a patient with a falsely negative glucose-6-phosphate dehydrogenase deficiency result., Rheumatology (Oxford)
Kaliman et al., 1999, Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress., Biochemistry Mosc.
Beydemir et al., 2002, Purification and characterization of glucose 6-phosphate dehydrogenase from sheep erythrocytes and inhibitory effects of some antibiotics on enzyme activity., J Enzyme Inhib Med Chem
Chan et al., 1975, Letter: Glucose-6-phosphate dehydrogenase deficiency and co-trimoxazole., Lancet
Janakiraman N et al., 1978, Hemolysis during BAL chelation therapy for high blood lead levels in two G6PD deficient children., Clin Pediatr (Phila)
Marsicano AR Jr et al., 1973, Fatal hemolysis from mafenide treatment of burns in a patient with glucose-6-phosphate dehydrogenase deficiency. Case report., Plast Reconstr Surg
Ozdemir et al., 2006, In vitro effects of some drugs on human red blood cell glucose-6-phosphate dehydrogenase enzyme activity., J Enzyme Inhib Med Chem
Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol
Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol
Pui CH et al., 1997, Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies., Leukemia
Akande M et al., 2017, Rasburicase-induced Hemolytic Anemia in an Adolescent With Unknown Glucose-6-Phosphate Dehydrogenase Deficiency., J Pediatr Pharmacol Ther
Cooling L, 2017, Brisk clinical response to erythrocytapheresis in a G6PD-deficient patient with rasburicase-induced methemoglobinemia., J Clin Apher
Montgomery KW et al., 2017, A perfect storm: Tumor lysis syndrome with rasburicase-induced methemoglobinemia in a G6PD deficient adult., J Clin Apher
Oluwasanjo A et al., 2015, Rasburicase-induced methaemoglobinaemia and G6PD deficiency in an unusual suspect., Br J Haematol
Zhang B et al., 2014, Tumor lysis syndrome and acute anemia in an African-American man with chronic lymphocytic leukemia., Oxf Med Case Reports
Bontant T et al., 2014, Methaemoglobinaemia in a G6PD-deficient child treated with rasburicase., BMJ Case Rep
McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
Relling MV et al., 2014, Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype., Clin Pharmacol Ther
Roberts DA et al., 2015, Rasburicase-induced methemoglobinemia in two African-American female patients: an under-recognized and continued problem., Eur J Haematol
Pansy J et al., 2014, Cyanosis in a male Nigerian infant with acute kidney injury: answers., Pediatr Nephrol
Cheah CY et al., 2013, Rasburicase causing severe oxidative hemolysis and methemoglobinemia in a patient with previously unrecognized glucose-6-phosphate dehydrogenase deficiency., Acta Haematol
Zaramella P et al., 2013, Lethal effect of a single dose of rasburicase in a preterm newborn infant., Pediatrics
Sonbol MB et al., 2013, Methemoglobinemia and hemolysis in a patient with G6PD deficiency treated with rasburicase., Am J Hematol
Ng JS et al., 2012, Methemoglobinemia induced by rasburicase in a pediatric patient: a case report and literature review., J Oncol Pharm Pract
Vadhan-Raj S et al., 2012, A randomized trial of a single-dose rasburicase versus five-daily doses in patients at risk for tumor lysis syndrome., Ann Oncol
Bain BJ, 2010, A ghostly presence-G6PD deficiency., Am J Hematol
Ducros J et al., 1991, Hemolytic anemia due to G6PD deficiency and urate oxidase in a kidney-transplant patient., Clin Nephrol
Joly P et al., 2009, [A severe G6PD deficiency revealed during a chemotherapy protocol including rasburicase]., Ann Biol Clin (Paris)
Bhat P et al., 2008, Exchange transfusion as treatment for rasburicase induced methemoglobinemia in a glucose-6-phosphate dehydrogenase deficient patient., Pediatr Blood Cancer
Borinstein SC et al., 2008, Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia., Pediatr Blood Cancer
Browning LA et al., 2005, Hemolysis and methemoglobinemia secondary to rasburicase administration., Ann Pharmacother
Bosly A et al., 2003, Rasburicase (recombinant urate oxidase) for the management of hyperuricemia in patients with cancer: report of an international compassionate use study., Cancer
Patte C et al., 2002, Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Française d'Oncologie Pédiatrique LMB89 protocol., Ann Oncol
Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.
Pritchard JA et al., 1965, Severe anemia with hemolysis and megaloblastic erythropoiesis. A reaction to nitrofurantoin administered during pregnancy., JAMA
Syzdół P et al., 1991, [Recurrent acute renal failure during the course of hemolytic crisis in a patient with glucose-6-phosphate dehydrogenase deficiency]., Pol Tyg Lek
Lavelle KJ et al., 1976, Hyperlactatemia and hemolysis in G6PD deficiency after nitrofurantoin ingestion., Am J Med Sci
Cherian et al., 1989, Effect of busulfan on crystalline lens--glutathione, glutathione reductase and glucose-6-phosphate dehydrogenase., Indian J. Exp. Biol.
Cohen SM et al., 1968, Ulcerative colitis and erythrocyte G6PD deficiency. Salicylazosulfapyridine-provoked hemolysis., JAMA
Srivatsa et al., 2003, Does nimesulide induce haemolysis in glucose-6-phosphate dehydrogenase deficiency?, Acta Paediatr.
Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.
Alloueche A et al., 2004, Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial., Lancet
Sulo J et al., 2002, Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial., Lancet
Luzzatto L, 2010, The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics., Lancet
Altikat et al., In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase., Pol J Pharmacol
Carette C et al., 2011, Diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency: from one crisis to another., Diabetes Metab
Vinzio S et al., 2004, Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency., Diabetes Res Clin Pract
Meloni G et al., 1996, Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM., Br J Haematol
Yilmaz et al., 2004, The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats., Pharmacol. Res.
Tungsiripat M et al., 2008, Prevalence and significance of G6PD deficiency in patients of an urban HIV clinic., J Int Assoc Physicians AIDS Care (Chic)
Sansone S et al., 2010, Ciprofloxacin-induced acute haemolytic anaemia in a patient with glucose-6-phosphate dehydrogenase Mediterranean deficiency: a case report., Ann Hematol
Dash S et al., 1977, Combined G-6PD and 6-PGD deficiency in a Hindu boy., Acta Haematol
Ali NA et al., 1999, Haemolytic potential of three chemotherapeutic agents and aspirin in glucose-6-phosphate dehydrogenase deficiency., East Mediterr Health J
Amitai Y et al., 1996, Glucose-6-phosphate dehydrogenase deficiency severely restricts the biotransformation of daunorubicin in human erythrocytes., J Lab Clin Med
Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Ribaya JD et al., 1979, Interrelationships in rats among dietary vitamin B6, glycine and hydroxyproline. Effects of oxalate, glyoxylate, glycolate, and glycine on liver enzymes., J Nutr

ARTENIMOL G6PD

Interaction Types & Directionality:

ligand

Interaction Info:

Publications:

Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol
GLYCOLIC ACID G6PD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Ribaya JD et al., 1979, Interrelationships in rats among dietary vitamin B6, glycine and hydroxyproline. Effects of oxalate, glyoxylate, glycolate, and glycine on liver enzymes., J Nutr
SULFAMETHOXAZOLE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sulfamethoxazole,Trimethoprim

Publications:
PRILOCAINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Prilocaine

Publications:
OXYMETAZOLINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Oxymetazoline,Tetracaine

Publications:
DABRAFENIB G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family BRAF inhibitor

Alteration G6PD:.

Alteration G6PD:S218F

Publications:
ERYTHROMYCIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Erythromycin,Sulfisoxazole

Publications:
TETRACAINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Tetracaine

Combination therapy Oxymetazoline,Tetracaine

Publications:
EPINEPHRINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Articaine,Epinephrine

Publications:
ARTICAINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Articaine,Epinephrine

Publications:
SULFISOXAZOLE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Erythromycin,Sulfisoxazole

Publications:
TRIMETHOPRIM G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sulfamethoxazole,Trimethoprim

Publications:
LIDOCAINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Prilocaine

Combination therapy Lidocaine,Tetracaine

Publications:

PHENAZOPYRIDINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Tishler M et al., 1983, Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency., Acta Haematol

Mercieca JE et al., 1982, Acute hemolytic anaemia due to phenazopyridine hydrochloride in G-6-PD deficient subject., Lancet

Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol

PEGLOTICASE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Owens RE et al., 2016, Hemolytic Anemia Induced by Pegloticase Infusion in a Patient With G6PD Deficiency., J Clin Rheumatol

Geraldino-Pardilla L et al., 2014, Methaemoglobinaemia and haemolysis following pegloticase infusion for refractory gout in a patient with a falsely negative glucose-6-phosphate dehydrogenase deficiency result., Rheumatology (Oxford)

PROPRANOLOL G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kaliman et al., 1999, Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress., Biochemistry Mosc.

PENICILLIN G POTASSIUM G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Beydemir et al., 2002, Purification and characterization of glucose 6-phosphate dehydrogenase from sheep erythrocytes and inhibitory effects of some antibiotics on enzyme activity., J Enzyme Inhib Med Chem

SULFADIAZINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol
CO-TRIMOXAZOLE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chan et al., 1975, Letter: Glucose-6-phosphate dehydrogenase deficiency and co-trimoxazole., Lancet
DIMERCAPROL G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Janakiraman N et al., 1978, Hemolysis during BAL chelation therapy for high blood lead levels in two G6PD deficient children., Clin Pediatr (Phila)
MAFENIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Marsicano AR Jr et al., 1973, Fatal hemolysis from mafenide treatment of burns in a patient with glucose-6-phosphate dehydrogenase deficiency. Case report., Plast Reconstr Surg
OMEPRAZOLE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ozdemir et al., 2006, In vitro effects of some drugs on human red blood cell glucose-6-phosphate dehydrogenase enzyme activity., J Enzyme Inhib Med Chem
DOXORUBICIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol
PROTOPORPHYRIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol

RASBURICASE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Pui CH et al., 1997, Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies., Leukemia

Akande M et al., 2017, Rasburicase-induced Hemolytic Anemia in an Adolescent With Unknown Glucose-6-Phosphate Dehydrogenase Deficiency., J Pediatr Pharmacol Ther

Cooling L, 2017, Brisk clinical response to erythrocytapheresis in a G6PD-deficient patient with rasburicase-induced methemoglobinemia., J Clin Apher

TRIAMCINOLONE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.

NITROFURANTOIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Pritchard JA et al., 1965, Severe anemia with hemolysis and megaloblastic erythropoiesis. A reaction to nitrofurantoin administered during pregnancy., JAMA

Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf

Syzdół P et al., 1991, [Recurrent acute renal failure during the course of hemolytic crisis in a patient with glucose-6-phosphate dehydrogenase deficiency]., Pol Tyg Lek

BUSULFAN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Cherian et al., 1989, Effect of busulfan on crystalline lens--glutathione, glutathione reductase and glucose-6-phosphate dehydrogenase., Indian J. Exp. Biol.
SULFASALAZINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Cohen SM et al., 1968, Ulcerative colitis and erythrocyte G6PD deficiency. Salicylazosulfapyridine-provoked hemolysis., JAMA
NIMESULIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Srivatsa et al., 2003, Does nimesulide induce haemolysis in glucose-6-phosphate dehydrogenase deficiency?, Acta Paediatr.
PREDNISOLONE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.

CHLORPROGUANIL G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Alloueche A et al., 2004, Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial., Lancet

Sulo J et al., 2002, Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial., Lancet

Luzzatto L, 2010, The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics., Lancet

DIAZEPAM G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Altikat et al., In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase., Pol J Pharmacol

GLYBURIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Carette C et al., 2011, Diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency: from one crisis to another., Diabetes Metab

Vinzio S et al., 2004, Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency., Diabetes Res Clin Pract

Meloni G et al., 1996, Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM., Br J Haematol

CISPLATIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Yilmaz et al., 2004, The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats., Pharmacol. Res.

DAPSONE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol

Tungsiripat M et al., 2008, Prevalence and significance of G6PD deficiency in patients of an urban HIV clinic., J Int Assoc Physicians AIDS Care (Chic)

Alloueche A et al., 2004, Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial., Lancet

CIPROFLOXACIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sansone S et al., 2010, Ciprofloxacin-induced acute haemolytic anaemia in a patient with glucose-6-phosphate dehydrogenase Mediterranean deficiency: a case report., Ann Hematol
QUININE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Dash S et al., 1977, Combined G-6PD and 6-PGD deficiency in a Hindu boy., Acta Haematol
SULFANILAMIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ali NA et al., 1999, Haemolytic potential of three chemotherapeutic agents and aspirin in glucose-6-phosphate dehydrogenase deficiency., East Mediterr Health J
DAUNORUBICIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Amitai Y et al., 1996, Glucose-6-phosphate dehydrogenase deficiency severely restricts the biotransformation of daunorubicin in human erythrocytes., J Lab Clin Med
CARMUSTINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol
SODIUM BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
CHLOROQUINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
OFLOXACIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHLORPROPAMIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TAFENOQUINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PERINDOPRIL G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PIOGLITAZONE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PROBENECID G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHLOROPROCAINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
METOCLOPRAMIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SITAMAQUINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
NICORANDIL G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TOLAZAMIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
EPIANDROSTERONE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GLIPIZIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TRAMETINIB G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
NORFLOXACIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CEFTRIAXONE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GLIMEPIRIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ROPIVACAINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SUCCIMER G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TOLBUTAMIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PRASTERONE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MEPIVACAINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ARTESUNATE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
FLUTAMIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
METABUTETHAMINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MOXIFLOXACIN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GLICLAZIDE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
AMODIAQUINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
EBSELEN G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PRIMAQUINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
HYDROXYCHLOROQUINE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
16.ALPHA.-BROMOEPIANDROSTERONE G6PD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000160211
- Version: 101_38
Alternate Names:

G6PD Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: G6PD

Version: 18-August-2020

Alternate Names:

PA28469 PharmGKB ID

Gene Info:

Publications:

Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol

Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol

Zhang P et al., 2013, An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines., Am J Trop Med Hyg

DrugBank: BE0001089

Version: 5.1.7

Alternate Names:

G6PD DrugBank Gene Name

P11413 UniProt Accession

2539 Entrez Gene Id

Gene Info:

Publications:

Ribaya JD et al., 1979, Interrelationships in rats among dietary vitamin B6, glycine and hydroxyproline. Effects of oxalate, glyoxylate, glycolate, and glycine on liver enzymes., J Nutr

Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

NCI: G6PD

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol

Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.

Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.

HingoraniCasas: ENSG00000160211
- Version: 31-May-2017
Alternate Names:

ENSG00000160211 Gene Symbol

G6PD Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: G6PD
- Version: 19.3
Alternate Names:

ENSG00000160211 Ensembl Gene ID

G6PD1 Human Protein Atlas Gene Synonym

Glucose-6-phosphate dehydrogenase Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: G6PD
- Version: 03-September-2020
Alternate Names:

Glucose-6-phosphate 1-dehydrogenase Gene Name

P11413 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: G6PD
- Version: 11-November-2018
Alternate Names:

G6PD Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Glucose-6-phosphate dehydrogenase
- Version: 2020.06.01
Alternate Names:

G6PD TTD Gene Abbreviation

T63484 TTD Target ID

Gene Info:

Publications:
CGI: G6PD
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:
DTC: G6PD
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:
FDA: G6PD
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Drug family	BRAF inhibitor
Alteration	G6PD:.
Alteration	G6PD:S218F

Combination therapy	Lidocaine,Tetracaine
Combination therapy	Oxymetazoline,Tetracaine

Combination therapy	Lidocaine,Prilocaine
Combination therapy	Lidocaine,Tetracaine

G6PD	DrugBank Gene Name
P11413	UniProt Accession
2539	Entrez Gene Id

ENSG00000160211	Ensembl Gene ID
G6PD1	Human Protein Atlas Gene Synonym
Glucose-6-phosphate dehydrogenase	Human Protein Atlas Gene Description

Glucose-6-phosphate 1-dehydrogenase	Gene Name
P11413	UniProt ID

G6PD Gene Record

G6PD 2539 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: ligand

Interaction Info:

Publications: Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Ribaya JD et al., 1979, Interrelationships in rats among dietary vitamin B6, glycine and hydroxyproline. Effects of oxalate, glyoxylate, glycolate, and glycine on liver enzymes., J Nutr

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Sulfamethoxazole,Trimethoprim

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Lidocaine,Prilocaine

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Oxymetazoline,Tetracaine

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Drug family BRAF inhibitor Alteration G6PD:. Alteration G6PD:S218F

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Erythromycin,Sulfisoxazole

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Lidocaine,Tetracaine Combination therapy Oxymetazoline,Tetracaine

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Articaine,Epinephrine

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Articaine,Epinephrine

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Erythromycin,Sulfisoxazole

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Sulfamethoxazole,Trimethoprim

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Lidocaine,Prilocaine Combination therapy Lidocaine,Tetracaine

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kaliman et al., 1999, Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress., Biochemistry Mosc.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Beydemir et al., 2002, Purification and characterization of glucose 6-phosphate dehydrogenase from sheep erythrocytes and inhibitory effects of some antibiotics on enzyme activity., J Enzyme Inhib Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chan et al., 1975, Letter: Glucose-6-phosphate dehydrogenase deficiency and co-trimoxazole., Lancet

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Janakiraman N et al., 1978, Hemolysis during BAL chelation therapy for high blood lead levels in two G6PD deficient children., Clin Pediatr (Phila)

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Marsicano AR Jr et al., 1973, Fatal hemolysis from mafenide treatment of burns in a patient with glucose-6-phosphate dehydrogenase deficiency. Case report., Plast Reconstr Surg

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ozdemir et al., 2006, In vitro effects of some drugs on human red blood cell glucose-6-phosphate dehydrogenase enzyme activity., J Enzyme Inhib Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

ligand

Publications:

Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Ribaya JD et al., 1979, Interrelationships in rats among dietary vitamin B6, glycine and hydroxyproline. Effects of oxalate, glyoxylate, glycolate, and glycine on liver enzymes., J Nutr

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sulfamethoxazole,Trimethoprim

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Prilocaine

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Oxymetazoline,Tetracaine

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family BRAF inhibitor

Alteration G6PD:.

Alteration G6PD:S218F

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Erythromycin,Sulfisoxazole

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Tetracaine

Combination therapy Oxymetazoline,Tetracaine

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Articaine,Epinephrine

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Articaine,Epinephrine

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Erythromycin,Sulfisoxazole

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Sulfamethoxazole,Trimethoprim

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Lidocaine,Prilocaine

Combination therapy Lidocaine,Tetracaine

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Kaliman et al., 1999, Regulation of delta-aminolevulinate synthase activity during the development of oxidative stress., Biochemistry Mosc.

Interaction Types & Directionality:

n/a

Publications:

Beydemir et al., 2002, Purification and characterization of glucose 6-phosphate dehydrogenase from sheep erythrocytes and inhibitory effects of some antibiotics on enzyme activity., J Enzyme Inhib Med Chem

Interaction Types & Directionality:

n/a

Publications:

Luzzatto L et al., 2014, G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications., Br J Haematol

Interaction Types & Directionality:

n/a

Publications:

Chan et al., 1975, Letter: Glucose-6-phosphate dehydrogenase deficiency and co-trimoxazole., Lancet

Interaction Types & Directionality:

n/a

Publications:

Janakiraman N et al., 1978, Hemolysis during BAL chelation therapy for high blood lead levels in two G6PD deficient children., Clin Pediatr (Phila)

Interaction Types & Directionality:

n/a

Publications:

Marsicano AR Jr et al., 1973, Fatal hemolysis from mafenide treatment of burns in a patient with glucose-6-phosphate dehydrogenase deficiency. Case report., Plast Reconstr Surg

Interaction Types & Directionality:

n/a

Publications:

Ozdemir et al., 2006, In vitro effects of some drugs on human red blood cell glucose-6-phosphate dehydrogenase enzyme activity., J Enzyme Inhib Med Chem

Interaction Types & Directionality:

n/a

Publications:

Sagone AL Jr et al., 1979, The effect of BCNU and adriamycin on normal and G6PD deficient erythrocytes., Am J Hematol

Interaction Types & Directionality:

n/a

Publications:

Malina et al., Glutathione as a cytoprotective antioxidant in erythrocytes of the newborn: the role of G6PD and zinc protoporphyrin: a hypothesis., Pediatr Hematol Oncol

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Im et al., 1975, Effects of intralesional injection of triamcinolone on glucose-6-phosphate dehydrogenase and alanine aminotransferase activity in keloids., Plast. Reconstr. Surg.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Cherian et al., 1989, Effect of busulfan on crystalline lens--glutathione, glutathione reductase and glucose-6-phosphate dehydrogenase., Indian J. Exp. Biol.

Interaction Types & Directionality:

n/a

Publications:

Cohen SM et al., 1968, Ulcerative colitis and erythrocyte G6PD deficiency. Salicylazosulfapyridine-provoked hemolysis., JAMA

Interaction Types & Directionality:

n/a

Publications:

Srivatsa et al., 2003, Does nimesulide induce haemolysis in glucose-6-phosphate dehydrogenase deficiency?, Acta Paediatr.

Interaction Types & Directionality:

n/a

Publications:

Yilmaz et al., 2006, Effects of additional Vitamin E and selenium supply on G6PDH activity in rats treated with high doses of glucocorticoid., Neurosci. Lett.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Altikat et al., In vitro effects of some anesthetic drugs on enzymatic activity of human red blood cell glucose 6-phosphate dehydrogenase., Pol J Pharmacol

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Yilmaz et al., 2004, The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats., Pharmacol. Res.

Interaction Types & Directionality:

n/a