2534 |
FYN PROTO-ONCOGENE, SRC FAMILY TYROSINE KINASE |
FYN |
SLK |
SYN |
p59-FYN |
137025 |
4037 |
ENSG00000010810 |
OTTHUMG00000016305 |
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (EC 2.7.1.112) (P59-FYN) (SYN) (SLK). [SOURCE:UNIPROT/SWISSPROT;ACC:P06241] |
P06241 |
TYROSINE-PROTEIN KINASE FYN |
FYN_HUMAN |
Src-like kinase |
Proto-oncogene c-Fyn |
Proto-oncogene Syn |
BE0000839 |
2026 |
NP_002028 |
NM_002037 |
Fyn tyrosine protein kinase |
T17980 |
Human Readable Name | DRUGGABLE GENOME |
Initial Gene Query | FYN |
Counted Citations from 1950-2000 | 2035 |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Interpro Type | Domain |
Interpro Acc | IPR001245 |
Human Readable Name | KINASE |
Uniprot Evidence | 1: Evidence at protein level |
Uniprot Status | Swiss-Prot |
Target Class | Enzymes |
Target Subclass | EC:2.7.10.2 |
Target Subclass | 2.7.10.2 |
Target Main Class | Enzymes |
GuideToPharmacology Gene Category Name | Src family |
GuideToPharmacology Gene Category ID | 619 |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
KINASE |
TYROSINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
ENZYME |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Tyrosine-protein kinase FYN inhibitor |
multitarget |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | dasatinib, BMS-354825,Sprycel |
Mechanism of Interaction | SRC inhibitor |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | SRC inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | SRC inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | ENMD-2076 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | SRC inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | SRC inhibitor |
FYN | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
FYN | Display Id |
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (EC 2.7.1.112) (P59-FYN) (SYN) (SLK). [SOURCE:UNIPROT/SWISSPROT;ACC:P06241] | Description |
ENSG00000010810 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
2534 | Entrez Gene ID |
Initial Gene Query | FYN |
Counted Citations from 1950-2000 | 2035 |
KINASE |
ENSG00000010810 | Ensembl Gene Id |
P06241 | Uniprot Accession |
2534 | Entrez Gene Id |
Target Subclass | 2.7.10.2 |
Target Main Class | Enzymes |
FYN | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.10.2 |
ENSG00000010810 | Ensembl Gene Id |
FYN | Uniprot Gene Name |
FYN_HUMAN | Uniprot Id |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Human Readable Name | DRUGGABLE GENOME |
KINASE, DRUGGABLE GENOME |
4037 | HUGO Gene ID |
4037 | HUGO Gene Symbol |
FYN proto-oncogene, Src family tyrosine kinase | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Src family |
GuideToPharmacology Gene Category ID | 619 |
ENZYME |
FYN | DrugBank Gene Name |
P06241 | UniProt Accession |
2534 | Entrez Gene Id |
ENSG00000010810 | Gene Symbol |
FYN | Ensembl Id |
DRUGGABLE GENOME |
FYN | Gene Symbol |
FYN | GENE_SYMBOL |
Tyrosine-protein kinase Fyn | UNIPROT |
Proto-oncogene Syn | UNIPROT |
Tyrosine-protein kinase Fyn | Gene Name |
P06241 | UniProt ID |
KINASE |
2534 | Gene ID |
SLK | dGene Synonym |
SYN | dGene Synonym |
KINASE, TYROSINE KINASE |
FYN | TTD Gene Abbreviation |
T17980 | TTD Target ID |
CELL SURFACE, TYROSINE KINASE, DRUG RESISTANCE |