DGIdb - FYN Gene Record

FYN 2534 Druggable GenomeDrug Resistance

Alternate Names:

2534
FYN PROTO-ONCOGENE, SRC FAMILY TYROSINE KINASE
FYN
SLK
SYN
p59-FYN
137025
4037
ENSG00000010810
OTTHUMG00000016305
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (EC 2.7.1.112) (P59-FYN) (SYN) (SLK). [SOURCE:UNIPROT/SWISSPROT;ACC:P06241]
P06241
TYROSINE-PROTEIN KINASE FYN
FYN_HUMAN
Src-like kinase
Proto-oncogene c-Fyn
Proto-oncogene Syn
BE0000839
2026
NP_002028
NM_002037
Fyn tyrosine protein kinase
T17980

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Initial Gene Query	FYN
Counted Citations from 1950-2000	2035
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Type	Domain
Interpro Acc	IPR001245
Human Readable Name	KINASE
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Human Readable Name	TYROSINE KINASE
Target Class	Enzymes
Target Subclass	EC:2.7.10.2
Target Subclass	2.7.10.2
Target Main Class	Enzymes
GuideToPharmacology Gene Category Name	Src family
GuideToPharmacology Gene Category ID	619
GuideToPharmacology Gene Type	enzyme
Gene Biotype	PROTEIN_CODING

(14 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
TYROSINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME

Publications:

Lindauer et al., 2010, Dasatinib., Recent Results Cancer Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Yamamoto et al., 1991, Role of src-like protooncogenes in lymphocyte proliferation., Int. Symp. Princess Takamatsu Cancer Res. Fund
Mills et al., 1992, Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells., Int. Immunol.
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

TG100-801 FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

Publications:
BOSUTINIB FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:
ACALABRUTINIB FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:
ILORASERTIB FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction SRC inhibitor

Publications:
XL-228 FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction SRC inhibitor

Publications:
JNJ-26483327 FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosine-protein kinase FYN inhibitor

Publications:
PEXMETINIB FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:
IBRUTINIB FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:
ENMD-981693 FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

Publications:

DASATINIB FYN

Interaction Types & Directionality:

multitarget

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name dasatinib, BMS-354825,Sprycel

Mechanism of Interaction SRC inhibitor

Publications:

Lindauer et al., 2010, Dasatinib., Recent Results Cancer Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

HESPERADIN FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
FOSTAMATINIB FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
NINTEDANIB FYN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Publications:
ENMD-2076 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

Publications:

ALDESLEUKIN FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Yamamoto et al., 1991, Role of src-like protooncogenes in lymphocyte proliferation., Int. Symp. Princess Takamatsu Cancer Res. Fund

Mills et al., 1992, Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells., Int. Immunol.

chembl:CHEMBL379975 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
OSI-632 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
AZAKENPAULLONE FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
R-406 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
VANDETANIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TOZASERTIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
KENPAULLONE FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL120077 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CEDIRANIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL460990 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PAZOPANIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CYC-116 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL406845 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PD-0166285 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL546797 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
BARASERTIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ADAVOSERTIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL606964 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RG-1530 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL460989 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PF-00562271 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
AST-487 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TAE-684 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ENTRECTINIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
DOVITINIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CENISERTIB FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL202721 FYN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000010810
- Version: 101_38
Alternate Names:

FYN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000010810
- Version: 26-July-2011
Alternate Names:

FYN Display Id

PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (EC 2.7.1.112) (P59-FYN) (SYN) (SLK). [SOURCE:UNIPROT/SWISSPROT;ACC:P06241] Description

ENSG00000010810 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
BaderLabGenes: FYN
- Version: February-2014
Alternate Names:

2534 Entrez Gene ID

Gene Info:

Initial Gene Query FYN

Counted Citations from 1950-2000 2035

Gene Categories:

KINASE

Publications:
TEND: P06241
- Version: 01-August-2011
Alternate Names:

ENSG00000010810 Ensembl Gene Id

P06241 Uniprot Accession

2534 Entrez Gene Id

Gene Info:

Target Subclass 2.7.10.2

Target Main Class Enzymes

Publications:
TdgClinicalTrial: P06241
- Version: January-2014
Alternate Names:

FYN Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Publications:
GuideToPharmacologyGenes: 2026
- Version: 4-March-2015
Alternate Names:

FYN proto-oncogene, Src family tyrosine kinase HUGO Gene Name

4037 HUGO Gene ID

FYN Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name Src family

GuideToPharmacology Gene Category ID 619

GuideToPharmacology Gene Type enzyme

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
HopkinsGroom: P06241
- Version: 11-September-2012
Alternate Names:

ENSG00000010810 Ensembl Gene Id

FYN Uniprot Gene Name

FYN_HUMAN Uniprot Id

Gene Info:

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom

Human Readable Name DRUGGABLE GENOME

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

DrugBank: BE0000839

Version: 5.1.7

Alternate Names:

FYN DrugBank Gene Name

P06241 UniProt Accession

2534 Entrez Gene Id

Gene Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Lindauer et al., 2010, Dasatinib., Recent Results Cancer Res.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

NCI: FYN

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Mills et al., 1992, Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells., Int. Immunol.

Yamamoto et al., 1991, Role of src-like protooncogenes in lymphocyte proliferation., Int. Symp. Princess Takamatsu Cancer Res. Fund

Werdich et al., 2005, Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events., Angiogenesis

DTC: FYN
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
HingoraniCasas: ENSG00000010810
- Version: 31-May-2017
Alternate Names:

ENSG00000010810 Gene Symbol

FYN Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: FYN
- Version: 12-May-2016
Alternate Names:

FYN Gene Symbol

Gene Info:

Publications:
ChemblInteractions: FYN
- Version: chembl_23
Alternate Names:

FYN GENE_SYMBOL

Tyrosine-protein kinase Fyn UNIPROT

Proto-oncogene Syn UNIPROT

Gene Info:

Publications:
GuideToPharmacologyInteractions: ENSG00000010810
- Version: 20-July-2020
Alternate Names:

FYN proto-oncogene, Src family tyrosine kinase GuideToPharmacology Name

P06241 UniProtKB ID

Gene Info:

Publications:
TTD: Fyn tyrosine protein kinase
- Version: 2020.06.01
Alternate Names:

FYN TTD Gene Abbreviation

T17980 TTD Target ID

Gene Info:

Publications:
Pharos: FYN
- Version: 03-September-2020
Alternate Names:

Tyrosine-protein kinase Fyn Gene Name

P06241 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
dGene: FYN
- Version: 27-Jun-2013
Alternate Names:

2534 Gene ID

SLK dGene Synonym

SYN dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
GO: FYN
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE, DRUG RESISTANCE, TYROSINE KINASE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Direct Interaction	yes
Mechanism of Interaction	Tyrosine-protein kinase FYN inhibitor

Novel drug target	Established target
Trial Name	dasatinib, BMS-354825,Sprycel
Mechanism of Interaction	SRC inhibitor

FYN	Display Id
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN (EC 2.7.1.112) (P59-FYN) (SYN) (SLK). [SOURCE:UNIPROT/SWISSPROT;ACC:P06241]	Description
ENSG00000010810	Ensembl Gene Id

FYN proto-oncogene, Src family tyrosine kinase	HUGO Gene Name
4037	HUGO Gene ID
FYN	Gene Symbol

ENSG00000010810	Ensembl Gene Id
FYN	Uniprot Gene Name
FYN_HUMAN	Uniprot Id

FYN	DrugBank Gene Name
P06241	UniProt Accession
2534	Entrez Gene Id

FYN	GENE_SYMBOL
Tyrosine-protein kinase Fyn	UNIPROT
Proto-oncogene Syn	UNIPROT

FYN proto-oncogene, Src family tyrosine kinase	GuideToPharmacology Name
P06241	UniProtKB ID

FYN Gene Record

FYN 2534 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction SRC inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction SRC inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tyrosine-protein kinase FYN inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

Publications:

Interaction Types & Directionality: multitarget inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name dasatinib, BMS-354825,Sprycel Mechanism of Interaction SRC inhibitor

Publications: Lindauer et al., 2010, Dasatinib., Recent Results Cancer Res. Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ENMD-2076 Novel drug target Established target

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

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Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

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Interaction Types & Directionality: n/a

Interaction Info:

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Interaction Types & Directionality: n/a

Interaction Info:

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Interaction Types & Directionality: n/a

Interaction Info:

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Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction SRC inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction SRC inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosine-protein kinase FYN inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

Interaction Types & Directionality:

multitarget

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name dasatinib, BMS-354825,Sprycel

Mechanism of Interaction SRC inhibitor

Publications:

Lindauer et al., 2010, Dasatinib., Recent Results Cancer Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

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n/a

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n/a

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n/a

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n/a

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n/a

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n/a

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n/a

Interaction Types & Directionality:

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Interaction Types & Directionality:

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