DGIdb - FOLR2 Gene Record

FOLR2 2350 Druggable Genome

Alternate Names:

2350
FOLATE RECEPTOR BETA
FOLR2
BETA-HFR
FBP
FBP/PL-1
FR-BETA
FR-P3
136425
3793
ENSG00000165457
OTTHUMG00000150394
FOLR1
FRbeta

Gene Info:

Gene Biotype	PROTEIN_CODING

(0 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME

Publications:

Golani LK et al., 2014, Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter., J Med Chem
Wlodarczyk et al., 2006, Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos., Neurotoxicology
Boyles et al., 2006, Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions., Environ. Health Perspect.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Dixit et al., Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells., Bioconjug. Chem.
Wang L et al., 2010, Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry., J Med Chem

FOLIC ACID FOLR2

Interaction Score: 61.83

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
25234128 16620997 17035141 11752352 16704197

Sources:
DTC
LOMETREXOL FOLR2

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20085328

Sources:
DTC

Ensembl: ENSG00000165457
- Version: 101_38
Alternate Names:

FOLR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

DTC: FOLR2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Golani LK et al., 2014, Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter., J Med Chem

Wang L et al., 2010, Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry., J Med Chem

HingoraniCasas: ENSG00000165457
- Version: 31-May-2017
Alternate Names:

ENSG00000165457 Gene Symbol

FOLR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: FOLR2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications: