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FOLH1 Gene Record

  • Summary
  • Interactions
  • Claims
  • FOLH1 2346 Druggable Genome

    Alternate Names:

    2346
    FOLATE HYDROLASE 1
    FOLH1
    FGCP
    FOLH
    GCP2
    GCPII
    NAALAD1
    NAALAdase
    PSM
    PSMA
    mGCP
    600934
    3788
    ENSG00000086205
    OTTHUMG00000166625
    Q04609
    Membrane glutamate carboxypeptidase
    Glutamate carboxypeptidase II
    Folylpoly-gamma-glutamate carboxypeptidase
    Cell growth-inhibiting gene 27 protein
    Glutamate carboxypeptidase 2
    NAALADase I
    N-acetylated-alpha-linked acidic dipeptidase I
    Prostate-specific membrane antigen
    Pteroylpoly-gamma-glutamate carboxypeptidase
    FOLH1_HUMAN
    PA28205
    T97071
    GIG27

    Gene Info:

    Target Main Class Enzymes
    Transmembrane Helix Count 1
    Target Subclass 3.4.17
    CancerCommons Reported Gene Name PSMA
    Target Class Enzymes
    Target Subclass EC:3.4.17
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Gregorakis et al., 1998, Prostate-specific membrane antigen: current and future utility., Semin. Urol. Oncol.
    Sodee et al., 1998, Prostate cancer and prostate bed SPECT imaging with ProstaScint: semiquantitative correlation with prostatic biopsy results., Prostate
    Sodee et al., 2005, Update on fused capromab pendetide imaging of prostate cancer., Clin Prostate Cancer
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Smith-Jones et al., 2000, In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen., Cancer Res.
    Dorababu P et al., 2012, Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL., Pharmacogenomics
    Pinto et al., 1996, Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells., Clin. Cancer Res.
    Slusher et al., 2000, Suramin potently inhibits the enzymatic activity of PSM., Prostate
    Wright et al., 1996, Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy., Urology
  • CAPROMAB   FOLH1

    Interaction Score: 44.97

    Interaction Types & Directionality:
    antibody (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9508077 9792131 15882479 11752352 11016653


    Sources:
    TdgClinicalTrial TEND TTD

  • MLN-591RL   FOLH1

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MLN-2704   FOLH1

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MDX-070   FOLH1

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate carboxypeptidase II other
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MIPSAGARGIN   FOLH1

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TECHNETIUM TC-99M TROFOLASTAT CHLORIDE   FOLH1

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ANDROSTANOLONE   FOLH1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8753752


    Sources:
    NCI

  • SURAMIN   FOLH1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10861758


    Sources:
    NCI

  • MERCAPTOPURINE   FOLH1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22838948


    Sources:
    PharmGKB

  • METHOTREXATE   FOLH1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9816319 22838948


    Sources:
    NCI PharmGKB

  • DOCETAXEL   FOLH1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Reported Cancer Type Prostate

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial CancerCommons

  • Ensembl: ENSG00000086205

    • Version: 101_38

    Alternate Names:
    FOLH1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q04609

    • Version: 01-August-2011

    Alternate Names:
    FOLH1_HUMAN Uniprot Id
    Q04609 Uniprot Accession
    ENSG00000086205 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Transmembrane Helix Count 1
    Target Subclass 3.4.17

    Publications:

  • TdgClinicalTrial: Q04609

    • Version: January-2014

    Alternate Names:
    FOLH1 Gene Symbol
    PSMA Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.17

    Publications:

  • CancerCommons: FOLH1

    • Version: 25-July-2013

    Alternate Names:
    2346 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name PSMA

    Publications:

  • PharmGKB: FOLH1

    • Version: 18-August-2020

    Alternate Names:
    PA28205 PharmGKB ID

    Gene Info:

    Publications:
    Dorababu P et al., 2012, Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL., Pharmacogenomics

  • NCI: FOLH1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Slusher et al., 2000, Suramin potently inhibits the enzymatic activity of PSM., Prostate
    Wright et al., 1996, Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy., Urology
    Noss et al., 2002, Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer., Gene

  • HingoraniCasas: ENSG00000086205

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000086205 Gene Symbol
    FOLH1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: FOLH

    • Version: chembl_23

    Alternate Names:
    NAALAD1 GENE_SYMBOL
    PSM GENE_SYMBOL
    PSMA GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: FOLH1

    • Version: 01-February-2022

    Alternate Names:
    FOLH GO Gene Synonym
    NAALAD1 GO Gene Synonym
    PSM GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, PROTEASE

    Publications:

  • dGene: FOLH1

    • Version: 27-Jun-2013

    Alternate Names:
    2346 Gene ID
    FGCP dGene Synonym
    FOLH dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Glutamate carboxypeptidase II

    • Version: 2020.06.01

    Alternate Names:
    GCPII TTD Gene Abbreviation
    T97071 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: FOLH1

    • Version: 01-February-2022

    Alternate Names:
    Glutamate carboxypeptidase 2 Gene Name
    Q04609 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • ClearityFoundationClinicalTrial: FOLH1

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21