DGIdb - FCGR1A Gene Record

FCGR1A 2209 Druggable Genome

Alternate Names:

2209
FC FRAGMENT OF IGG RECEPTOR IA
FCGR1A
CD64
CD64A
FCRI
IGFR1
146760
3613
ENSG00000150337
OTTHUMG00000012089
FCG1
FcgammaRIa
FCGR1
High affinity immunoglobulin gamma Fc receptor I
Fc-gamma RI
Fc-gamma RIA
CD_antigen=CD64
IgG Fc receptor I
BE0000710
P12314

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Simms et al., 1991, Monokines released during short-term Fc gamma receptor phagocytosis up-regulate polymorphonuclear leukocytes and monocyte-phagocytic function., J. Immunol.
Hofmann HP et al., 2016, Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator etanercept (Enbrel(®))., Expert Opin Biol Ther
Arora T et al., 2009, Differences in binding and effector functions between classes of TNF antagonists., Cytokine
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
White AL et al., 2013, FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs., Cancer Immunol Immunother
Dudek S et al., 2019, Human Fcγ receptors compete for TGN1412 binding that determines the antibody's effector function., Eur J Immunol
Curnow, Clinical experience with CD64-directed immunotherapy. An overview., Cancer Immunol. Immunother.
Wang Y et al., 2004, Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro., Angiogenesis
Hiatt A et al., 2014, Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy., Proc Natl Acad Sci U S A
Negri et al., 1995, In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab')2 bispecific monoclonal antibody., Br. J. Cancer
Hudkins RL et al., 2012, Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent., J Med Chem
Seimetz D et al., 2010, Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy., Cancer Treat Rev
Nagai Y et al., 2019, Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys., Xenobiotica
Tamura K et al., 2019, Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study., Lancet Oncol

TRASTUZUMAB DERUXTECAN FCGR1A

Interaction Score: 6.55

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

PMIDs:
30351177 31047803

Sources:
DrugBank
MDX-447 FCGR1A

Interaction Score: 6.55

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction High affinity immunoglobulin gamma Fc receptor I other

Direct Interaction yes

PMIDs:
9435876

Sources:
NCI ChemblInteractions
NATALIZUMAB FCGR1A

Interaction Score: 2.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31002172 17139284 17016423

Sources:
DrugBank
PALIVIZUMAB FCGR1A

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 24711420

Sources:
DrugBank
MDX-210 FCGR1A

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction High affinity immunoglobulin gamma Fc receptor I other

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALEMTUZUMAB FCGR1A

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23543215 17139284 17016423

Sources:
DrugBank
CATUMAXOMAB FCGR1A

Interaction Score: 1.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20347527

Sources:
DrugBank
ETANERCEPT FCGR1A

Interaction Score: 0.87

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
27463856 19128982 17139284 17016423

Sources:
DrugBank
SARILUMAB FCGR1A

Interaction Score: 0.73

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
DACLIZUMAB FCGR1A

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1828823

Sources:
DrugBank
CEP-11981 FCGR1A

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22148921

Sources:
DTC
BEVACIZUMAB FCGR1A

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423 15886877

Sources:
DrugBank
CETUXIMAB FCGR1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7547242

Sources:
DrugBank

Ensembl: ENSG00000150337
- Version: 101_38
Alternate Names:

FCGR1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

DrugBank: BE0000710

Version: 5.1.7

Alternate Names:

FCGR1A DrugBank Gene Name

P12314 UniProt Accession

2209 Entrez Gene Id

Gene Info:

Publications:

Hofmann HP et al., 2016, Characterization and non-clinical assessment of the proposed etanercept biosimilar GP2015 with originator etanercept (Enbrel(®))., Expert Opin Biol Ther

Arora T et al., 2009, Differences in binding and effector functions between classes of TNF antagonists., Cytokine

Negri et al., 1995, In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab')2 bispecific monoclonal antibody., Br. J. Cancer

NCI: FCGR1A

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Curnow, Clinical experience with CD64-directed immunotherapy. An overview., Cancer Immunol. Immunother.

Cassatella et al., 1991, Interferon-gamma transcriptionally modulates the expression of the genes for the high affinity IgG-Fc receptor and the 47-kDa cytosolic component of NADPH oxidase in human polymorphonuclear leukocytes., J. Biol. Chem.

DTC: FCGR1A

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Hudkins RL et al., 2012, Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agent., J Med Chem

HingoraniCasas: ENSG00000150337
- Version: 31-May-2017
Alternate Names:

ENSG00000150337 Gene Symbol

FCGR1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: FCG1
- Version: chembl_23
Alternate Names:

FCGR1 GENE_SYMBOL

IGFR1 GENE_SYMBOL

FCGR1A GENE_SYMBOL

Gene Info:

Publications:

Mechanism of Interaction	High affinity immunoglobulin gamma Fc receptor I other
Direct Interaction	yes

FCGR1A	DrugBank Gene Name
P12314	UniProt Accession
2209	Entrez Gene Id

FCGR1A Gene Record

FCGR1A 2209 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info:

PMIDs: 30351177 31047803

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction High affinity immunoglobulin gamma Fc receptor I other Direct Interaction yes

PMIDs: 9435876

Sources: NCI ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31002172 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 24711420

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction High affinity immunoglobulin gamma Fc receptor I other Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23543215 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 20347527

Sources: DrugBank

Interaction Types & Directionality: ligand

Interaction Info:

PMIDs: 27463856 19128982 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1828823

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22148921

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423 15886877

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7547242

Sources: DrugBank

Ensembl: ENSG00000150337

Alternate Names: FCGR1A Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

DrugBank: BE0000710

Alternate Names: FCGR1A DrugBank Gene Name P12314 UniProt Accession 2209 Entrez Gene Id

Gene Info:

NCI: FCGR1A

Alternate Names:

Gene Info:

DTC: FCGR1A

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000150337

Alternate Names: ENSG00000150337 Gene Symbol FCGR1A Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: FCG1

Alternate Names: FCGR1 GENE_SYMBOL IGFR1 GENE_SYMBOL FCGR1A GENE_SYMBOL

Gene Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

PMIDs:
30351177 31047803

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction High affinity immunoglobulin gamma Fc receptor I other

Direct Interaction yes

PMIDs:
9435876

Sources:
NCI ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
31002172 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 24711420

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction High affinity immunoglobulin gamma Fc receptor I other

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23543215 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
20347527

Sources:
DrugBank

Interaction Types & Directionality:

ligand

PMIDs:
27463856 19128982 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

other/unknown

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
1828823

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
22148921

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423 15886877

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
7547242

Sources:
DrugBank

Alternate Names:

FCGR1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

FCGR1A DrugBank Gene Name

P12314 UniProt Accession

2209 Entrez Gene Id

Alternate Names:

ENSG00000150337 Gene Symbol

FCGR1A Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

FCGR1 GENE_SYMBOL

IGFR1 GENE_SYMBOL

FCGR1A GENE_SYMBOL