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FASN Gene Record

  • Summary
  • Interactions
  • Claims
  • FASN 2194 Druggable Genome

    Alternate Names:

    2194
    FATTY ACID SYNTHASE
    FASN
    FAS
    OA-519
    SDR27X1
    600212
    3594
    ENSG00000169710
    OTTHUMG00000178527
    P49327
    FATTY ACID SYNTHASE (EC 2.3.1.85) [INCLUDES: [ACYL-CARRIER-PROTEIN] S- ACETYLTRANSFERASE (EC 2.3.1.38); [ACYL-CARRIER-PROTEIN] S- MALONYLTRANSFERASE (EC 2.3.1.39); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE (EC 2.3.1.41); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] R
    3-HYDROXYPALMITOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE
    FAS_HUMAN
    T16514

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.3.1.85
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE
    Interpro Name Short-chain dehydrogenase/reductase SDR
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Short Name DH_sc/Rdtase_SDR
    Interpro Acc IPR002198
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    SHORT CHAIN DEHYDROGENASE REDUCTASE
    ENZYME

    Publications:

    Heiligtag et al., 2002, Key role of mitochondria in cerulenin-mediated apoptosis., Cell Death Differ.
    Ronnett et al., 2005, Fatty acid metabolism as a target for obesity treatment., Physiol. Behav.
    Lupu et al., 2006, Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?, Curr Pharm Biotechnol
    Li et al., 2001, Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53., Cancer Res.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Flavin et al., 2010, Fatty acid synthase as a potential therapeutic target in cancer., Future Oncol
    Oskouian et al., 1999, YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae., Mol. Gen. Genet.
    Menendez et al., 2005, Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity., Int. J. Cancer
    Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci
    Xiong et al., 1998, Identification of thyroid hormone response elements in the human fatty acid synthase promoter., Proc. Natl. Acad. Sci. U.S.A.
    Purohit et al., 2006, Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase., J. Org. Chem.
    Knowles et al., 2004, A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2., J. Biol. Chem.
    Menendez et al., 2005, Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene., Ann. Oncol.
    Kridel et al., 2004, Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity., Cancer Res.
    Kremer et al., 2005, Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol., Mol. Microbiol.
    Joles et al., 1995, Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion., Kidney Int.
  • CERULENIN   FASN

    Interaction Score: 23.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    12181752 15878185 17168665 11245456 11752352 20373869 10102370


    Sources:
    TTD

  • CHEMBL578883   FASN

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORGLUMIDE SODIUM   FASN

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PRETOMANID   FASN

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL577862   FASN

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ORLISTAT   FASN

    Interaction Score: 2.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name orlistat,Xenical
    Novel drug target Established target

    PMIDs:
    16749788 15138278 15870086 15026345 11752352 16091048


    Sources:
    TdgClinicalTrial

  • CHEMBL1255647   FASN

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL604664   FASN

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL585030   FASN

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DNQX   FASN

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL586937   FASN

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ADRIAMYCIN   FASN

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7723242


    Sources:
    NCI

  • PENTABROMOPHENOL   FASN

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LIOTHYRONINE SODIUM   FASN

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9770474


    Sources:
    NCI

  • CHEMBL523200   FASN

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FENTICLOR   FASN

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PYROGALLOL RED   FASN

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RISPERIDONE   FASN

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17052361


    Sources:
    NCI

  • CLOZAPINE   FASN

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17052361


    Sources:
    NCI

  • HEXACHLOROPHENE   FASN

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PACLITAXEL   FASN

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15657900


    Sources:
    NCI

  • Ensembl: ENSG00000169710

    • Version: 101_38

    Alternate Names:
    FASN Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000169710

    • Version: 26-July-2011

    Alternate Names:
    FASN Display Id
    FATTY ACID SYNTHASE (EC 2.3.1.85) [INCLUDES: [ACYL-CARRIER-PROTEIN] S- ACETYLTRANSFERASE (EC 2.3.1.38); [ACYL-CARRIER-PROTEIN] S- MALONYLTRANSFERASE (EC 2.3.1.39); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE (EC 2.3.1.41); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] R Description
    ENSG00000169710 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P49327

    • Version: 11-September-2012

    Alternate Names:
    FAS_HUMAN Uniprot Id
    2194 Entrez Gene Id
    3-HYDROXYPALMITOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE Uniprot Protein Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE
    Interpro Name Short-chain dehydrogenase/reductase SDR

    Gene Categories:
    DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

    Publications:

  • TdgClinicalTrial: P49327

    • Version: January-2014

    Alternate Names:
    FASN Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.3.1.85

    Publications:

  • TTD: Fatty acid synthase

    • Version: 2020.06.01

    Alternate Names:
    FASN TTD Gene Abbreviation
    T16514 TTD Target ID

    Gene Info:

    Publications:
    Oslob JD et al., 2012, Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation., ACS Med Chem Lett

  • NCI: FASN

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci
    De Schrijver et al., 2003, RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells., Cancer Res.
    Eder et al., 2003, Effects of dietary thermoxidized fats on expression and activities of hepatic lipogenic enzymes in rats., Lipids

  • HingoraniCasas: ENSG00000169710

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000169710 Gene Symbol
    FASN Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: FASN

    • Version: 01-February-2022

    Alternate Names:
    Fatty acid synthase Gene Name
    P49327 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • DTC: FASN

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21