DGIdb - FASN Gene Record

FASN 2194 Druggable Genome

Alternate Names:

2194
FATTY ACID SYNTHASE
FASN
FAS
OA-519
SDR27X1
600212
3594
ENSG00000169710
OTTHUMG00000178527
P49327
FATTY ACID SYNTHASE (EC 2.3.1.85) [INCLUDES: [ACYL-CARRIER-PROTEIN] S- ACETYLTRANSFERASE (EC 2.3.1.38); [ACYL-CARRIER-PROTEIN] S- MALONYLTRANSFERASE (EC 2.3.1.39); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE (EC 2.3.1.41); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] R
3-HYDROXYPALMITOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE
FAS_HUMAN
T16514

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.3.1.85
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	SHORT CHAIN DEHYDROGENASE REDUCTASE
Interpro Name	Short-chain dehydrogenase/reductase SDR
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Short Name	DH_sc/Rdtase_SDR
Interpro Acc	IPR002198
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
SHORT CHAIN DEHYDROGENASE REDUCTASE
ENZYME

Publications:

Heiligtag et al., 2002, Key role of mitochondria in cerulenin-mediated apoptosis., Cell Death Differ.
Ronnett et al., 2005, Fatty acid metabolism as a target for obesity treatment., Physiol. Behav.
Lupu et al., 2006, Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?, Curr Pharm Biotechnol
Li et al., 2001, Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53., Cancer Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Flavin et al., 2010, Fatty acid synthase as a potential therapeutic target in cancer., Future Oncol
Oskouian et al., 1999, YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae., Mol. Gen. Genet.
Menendez et al., 2005, Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity., Int. J. Cancer
Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci
Xiong et al., 1998, Identification of thyroid hormone response elements in the human fatty acid synthase promoter., Proc. Natl. Acad. Sci. U.S.A.
Purohit et al., 2006, Practical, catalytic, asymmetric synthesis of beta-lactones via a sequential ketene dimerization/hydrogenation process: inhibitors of the thioesterase domain of fatty acid synthase., J. Org. Chem.
Knowles et al., 2004, A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2., J. Biol. Chem.
Menendez et al., 2005, Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene., Ann. Oncol.
Kridel et al., 2004, Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity., Cancer Res.
Kremer et al., 2005, Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol., Mol. Microbiol.
Joles et al., 1995, Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion., Kidney Int.

CERULENIN FASN

Interaction Score: 23.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12181752 15878185 17168665 11245456 11752352 20373869 10102370

Sources:
TTD
CHEMBL578883 FASN

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LORGLUMIDE SODIUM FASN

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PRETOMANID FASN

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL577862 FASN

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ORLISTAT FASN

Interaction Score: 2.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name orlistat,Xenical

Novel drug target Established target

PMIDs:
16749788 15138278 15870086 15026345 11752352 16091048

Sources:
TdgClinicalTrial
CHEMBL1255647 FASN

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL604664 FASN

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL585030 FASN

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DNQX FASN

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL586937 FASN

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ADRIAMYCIN FASN

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7723242

Sources:
NCI
PENTABROMOPHENOL FASN

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LIOTHYRONINE SODIUM FASN

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9770474

Sources:
NCI
CHEMBL523200 FASN

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENTICLOR FASN

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYROGALLOL RED FASN

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RISPERIDONE FASN

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17052361

Sources:
NCI
CLOZAPINE FASN

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17052361

Sources:
NCI
HEXACHLOROPHENE FASN

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PACLITAXEL FASN

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15657900

Sources:
NCI

Ensembl: ENSG00000169710
- Version: 101_38
Alternate Names:

FASN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000169710

Version: 26-July-2011

Alternate Names:

FASN Display Id

FATTY ACID SYNTHASE (EC 2.3.1.85) [INCLUDES: [ACYL-CARRIER-PROTEIN] S- ACETYLTRANSFERASE (EC 2.3.1.38); [ACYL-CARRIER-PROTEIN] S- MALONYLTRANSFERASE (EC 2.3.1.39); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE (EC 2.3.1.41); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] R Description

ENSG00000169710 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P49327
- Version: 11-September-2012
Alternate Names:

FAS_HUMAN Uniprot Id

2194 Entrez Gene Id

3-HYDROXYPALMITOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE

Interpro Name Short-chain dehydrogenase/reductase SDR

Gene Categories:

DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

Publications:
TdgClinicalTrial: P49327
- Version: January-2014
Alternate Names:

FASN Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.3.1.85

Publications:
TTD: Fatty acid synthase
- Version: 2020.06.01
Alternate Names:

FASN TTD Gene Abbreviation

T16514 TTD Target ID

Gene Info:

Publications:

Oslob JD et al., 2012, Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation., ACS Med Chem Lett

NCI: FASN

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Fernø et al., 2006, Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs., BMC Neurosci

De Schrijver et al., 2003, RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells., Cancer Res.

Eder et al., 2003, Effects of dietary thermoxidized fats on expression and activities of hepatic lipogenic enzymes in rats., Lipids

HingoraniCasas: ENSG00000169710
- Version: 31-May-2017
Alternate Names:

ENSG00000169710 Gene Symbol

FASN Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: FASN
- Version: 01-February-2022
Alternate Names:

Fatty acid synthase Gene Name

P49327 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
DTC: FASN
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Trial Name	orlistat,Xenical
Novel drug target	Established target

FASN	Display Id
FATTY ACID SYNTHASE (EC 2.3.1.85) [INCLUDES: [ACYL-CARRIER-PROTEIN] S- ACETYLTRANSFERASE (EC 2.3.1.38); [ACYL-CARRIER-PROTEIN] S- MALONYLTRANSFERASE (EC 2.3.1.39); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE (EC 2.3.1.41); 3-OXOACYL-[ACYL-CARRIER-PROTEIN] R	Description
ENSG00000169710	Ensembl Gene Id

FAS_HUMAN	Uniprot Id
2194	Entrez Gene Id
3-HYDROXYPALMITOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE	Uniprot Protein Name

FASN Gene Record

FASN 2194 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 12181752 15878185 17168665 11245456 11752352 20373869 10102370

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name orlistat,Xenical Novel drug target Established target

PMIDs: 16749788 15138278 15870086 15026345 11752352 16091048

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7723242

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9770474

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17052361

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
12181752 15878185 17168665 11245456 11752352 20373869 10102370

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name orlistat,Xenical

Novel drug target Established target

PMIDs:
16749788 15138278 15870086 15026345 11752352 16091048

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7723242

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9770474

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17052361

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17052361

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15657900

Sources:
NCI

Alternate Names:

FASN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

FAS_HUMAN Uniprot Id

2194 Entrez Gene Id

3-HYDROXYPALMITOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE

Interpro Name Short-chain dehydrogenase/reductase SDR

Gene Categories:

DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

Alternate Names:

FASN Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.3.1.85

Alternate Names:

FASN TTD Gene Abbreviation

T16514 TTD Target ID

Publications:

Oslob JD et al., 2012, Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation., ACS Med Chem Lett

Alternate Names:

ENSG00000169710 Gene Symbol

FASN Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Fatty acid synthase Gene Name

P49327 UniProt ID

Gene Categories:

ENZYME