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FAAH Gene Record

  • Summary
  • Interactions
  • Claims
  • FAAH 2166 Druggable Genome

    Alternate Names:

    2166
    FATTY ACID AMIDE HYDROLASE
    FAAH
    FAAH-1
    PSAB
    602935
    3553
    ENSG00000117480
    OTTHUMG00000007811
    1400
    O00519
    FAAH1
    Oleamide hydrolase 1
    Anandamide amidohydrolase 1
    Fatty-acid amide hydrolase 1
    PA27955
    BE0002194
    T34389
    T11754

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.5.1.99
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category ID 799
    GuideToPharmacology Gene Category Name Hydrolases
    GuideToPharmacology Gene Category Name <i>N</i>-Acylethanolamine turnover
    GuideToPharmacology Gene Category ID 273
    (7 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Johnson et al., 2011, Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor., ACS Med Chem Lett
    Högestätt et al., 2005, Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system., J. Biol. Chem.
    Meyers MJ et al., 2011, Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain., Bioorg Med Chem Lett
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Johnson DS et al., 2009, Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett
    Feledziak M et al., 2013, An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH)., Eur J Med Chem
    Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol
    Vincent F et al., 2009, Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors., Bioorg Med Chem Lett
    Patel et al., 2003, The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Schuel, 2006, Tuning the oviduct to the anandamide tone., J. Clin. Invest.
    Sim MS et al., 2013, Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population., Pharmacogenomics
    Zhang W et al., 2020, FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence., Ann Hum Genet
    Feledziak M et al., 2011, SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process., J Med Chem
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Tyndale RF et al., 2007, The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians., Am J Med Genet B Neuropsychiatr Genet
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
  • PF-04457845   FAAH

    Interaction Score: 9.88

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of human FAAH <i>in vitro</i>.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    21666860


    Sources:
    DTC TTD GuideToPharmacology

  • JNJ-42165279   FAAH

    Interaction Score: 4.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • CHEMBL367966   FAAH

    Interaction Score: 4.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23287055


    Sources:
    DTC

  • CHEMBL560590   FAAH

    Interaction Score: 4.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23287055


    Sources:
    DTC

  • DODECANOL   FAAH

    Interaction Score: 4.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1915783   FAAH

    Interaction Score: 4.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21924613


    Sources:
    DTC

  • URB-597   FAAH

    Interaction Score: 3.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    19386497 23287055 21666860


    Sources:
    DTC GuideToPharmacology

  • PHENMEDIPHAM   FAAH

    Interaction Score: 1.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19850474


    Sources:
    DTC

  • THIOPENTAL   FAAH

    Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    12839875 11752352


    Sources:
    TTD DrugBank

  • DRONABINOL   FAAH

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16886056


    Sources:
    NCI

  • ANANDAMIDE   FAAH

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21899370


    Sources:
    DTC

  • METHAMPHETAMINE   FAAH

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23556448 31789429


    Sources:
    PharmGKB

  • NABIXIMOLS   FAAH

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inducer (activating)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17290447 26264914


    Sources:
    PharmGKB DrugBank

  • ACETAMINOPHEN   FAAH

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Anandamide amidohydrolase inhibitor
    Direct Interaction yes

    PMIDs:
    15987694


    Sources:
    NCI ChemblInteractions

  • IBUPROFEN   FAAH

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25502615


    Sources:
    PharmGKB

  • QUETIAPINE   FAAH

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20631561


    Sources:
    PharmGKB

  • ARIPIPRAZOLE   FAAH

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20631561


    Sources:
    PharmGKB

  • PROPOFOL   FAAH

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RISPERIDONE   FAAH

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20631561


    Sources:
    PharmGKB

  • OLANZAPINE   FAAH

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20631561


    Sources:
    PharmGKB

  • HALOPERIDOL   FAAH

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20631561


    Sources:
    PharmGKB

  • CLOZAPINE   FAAH

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20631561


    Sources:
    PharmGKB

  • FOSTAMATINIB   FAAH

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

  • Ensembl: ENSG00000117480

    • Version: 101_38

    Alternate Names:
    FAAH Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: O00519

    • Version: January-2014

    Alternate Names:
    FAAH Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.5.1.99

    Publications:

  • GuideToPharmacology: 2166

    • Version: 29-September-2020

    Alternate Names:
    3553 HUGO Gene ID
    3553 HUGO Gene Symbol
    fatty acid amide hydrolase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Hydrolases
    GuideToPharmacology Gene Category ID 799
    GuideToPharmacology Gene Category Name <i>N</i>-Acylethanolamine turnover

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: FAAH

    • Version: 18-August-2020

    Alternate Names:
    PA27955 PharmGKB ID

    Gene Info:

    Publications:
    Monteleone P et al., 2010, Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain., J Clin Psychopharmacol
    Sim MS et al., 2013, Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population., Pharmacogenomics
    Zhang W et al., 2020, FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence., Ann Hum Genet

  • DrugBank: BE0002194

    • Version: 5.1.7

    Alternate Names:
    FAAH DrugBank Gene Name
    O00519 UniProt Accession
    2166 Entrez Gene Id

    Gene Info:

    Publications:
    Patel et al., 2003, The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • TTD: Fatty acid amide hydrolase

    • Version: 2020.06.01

    Alternate Names:
    FAAH TTD Gene Abbreviation
    T11754 TTD Target ID

    Gene Info:

    Publications:
    Otrubova K et al., 2011, The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett

  • NCI: FAAH

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Högestätt et al., 2005, Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system., J. Biol. Chem.
    Maccarrone et al., 2003, Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism., J. Neurochem.
    Schuel, 2006, Tuning the oviduct to the anandamide tone., J. Clin. Invest.

  • DTC: FAAH

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Johnson DS et al., 2009, Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)., Bioorg Med Chem Lett
    Feledziak M et al., 2013, An unprecedented reversible mode of action of β-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH)., Eur J Med Chem
    Johnson et al., 2011, Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor., ACS Med Chem Lett

  • HingoraniCasas: ENSG00000117480

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000117480 Gene Symbol
    FAAH Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: FAAH1

    • Version: chembl_23

    Alternate Names:
    FAAH GENE_SYMBOL
    FAAH1 GENE_SYMBOL
    Fatty-acid amide hydrolase 1 UNIPROT

    Gene Info:

    Publications:

  • TTD: Fatty-acid amide hydrolase 1

    • Version: 2020.06.01

    Alternate Names:
    FAAH1 TTD Gene Abbreviation
    T34389 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21