DGIdb - F2RL1 Gene Record

F2RL1 2150 Druggable Genome

Alternate Names:

2150
F2R LIKE TRYPSIN RECEPTOR 1
F2RL1
GPR11
PAR2
600933
3538
ENSG00000164251
OTTHUMG00000102118
PAR2_HUMAN
P55085
PROTEINASE-ACTIVATED RECEPTOR 2, ALTERNATE CLEAVED 1
PROTEINASE ACTIVATED RECEPTOR 2 PRECURSOR (PAR-2) (THROMBIN RECEPTOR- LIKE 1) (COAGULATION FACTOR II RECEPTOR-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55085]
Proteinase-activated receptor 2

Gene Info:

Interpro Acc	IPR000276
Interpro Type	Family
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Evidence	1: Evidence at protein level
Interpro Name	GPCR, rhodopsin-like, 7TM
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

KINASE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME
ENZYME

Publications:

Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.
Seitzberg JG et al., 2008, Discovery of potent and selective small-molecule PAR-2 agonists., J Med Chem
Ishikawa C et al., 2009, Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes., Antimicrob Agents Chemother

CHEMBL494502 F2RL1

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18720984

Sources:
DTC
CHEMBL493076 F2RL1

Interaction Score: 15.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
18720984

Sources:
DTC
MINOCYCLINE F2RL1

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19258275

Sources:
DTC
ROXITHROMYCIN F2RL1

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18212111

Sources:
DTC
DOXYCYCLINE F2RL1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19258275

Sources:
DTC
CLARITHROMYCIN F2RL1

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18212111

Sources:
DTC
TETRACYCLINE F2RL1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19258275

Sources:
DTC
ERYTHROMYCIN F2RL1

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18212111

Sources:
DTC

Ensembl: ENSG00000164251
- Version: 101_38
Alternate Names:

F2RL1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P55085
- Version: 11-September-2012
Alternate Names:

PROTEINASE-ACTIVATED RECEPTOR 2, ALTERNATE CLEAVED 1 Uniprot Protein Name

ENSG00000164251 Ensembl Gene Id

2150 Entrez Gene Id

Gene Info:

Interpro Acc IPR000276

Interpro Type Family

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000164251

Version: 26-July-2011

Alternate Names:

ENSG00000164251 Ensembl Gene Id

F2RL1 Display Id

PROTEINASE ACTIVATED RECEPTOR 2 PRECURSOR (PAR-2) (THROMBIN RECEPTOR- LIKE 1) (COAGULATION FACTOR II RECEPTOR-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55085] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: F2RL1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.

DTC: F2RL1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.

Ishikawa C et al., 2009, Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes., Antimicrob Agents Chemother

Seitzberg JG et al., 2008, Discovery of potent and selective small-molecule PAR-2 agonists., J Med Chem

HingoraniCasas: ENSG00000164251
- Version: 31-May-2017
Alternate Names:

ENSG00000164251 Gene Symbol

F2RL1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: F2RL1
- Version: 01-February-2022
Alternate Names:

GPR11 GO Gene Synonym

PAR2 GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: F2RL1
- Version: 27-Jun-2013
Alternate Names:

2150 Gene ID

GPR11 dGene Synonym

PAR2 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
Pharos: F2RL1
- Version: 01-February-2022
Alternate Names:

Proteinase-activated receptor 2 Gene Name

P55085 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME

Publications:

PROTEINASE-ACTIVATED RECEPTOR 2, ALTERNATE CLEAVED 1	Uniprot Protein Name
ENSG00000164251	Ensembl Gene Id
2150	Entrez Gene Id

F2RL1 Gene Record

F2RL1 2150 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18720984

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 18720984

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19258275

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18212111

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19258275

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18212111

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19258275

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18212111

Sources: DTC

Ensembl: ENSG00000164251

Alternate Names: F2RL1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P55085

Alternate Names: PROTEINASE-ACTIVATED RECEPTOR 2, ALTERNATE CLEAVED 1 Uniprot Protein Name ENSG00000164251 Ensembl Gene Id 2150 Entrez Gene Id

Gene Info: Interpro Acc IPR000276 Interpro Type Family Uniprot Status Swiss-Prot

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000164251

Alternate Names: ENSG00000164251 Ensembl Gene Id F2RL1 Display Id PROTEINASE ACTIVATED RECEPTOR 2 PRECURSOR (PAR-2) (THROMBIN RECEPTOR- LIKE 1) (COAGULATION FACTOR II RECEPTOR-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55085] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: F2RL1

Alternate Names:

Gene Info:

Publications: Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.

DTC: F2RL1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000164251

Alternate Names: ENSG00000164251 Gene Symbol F2RL1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: F2RL1

Alternate Names: GPR11 GO Gene Synonym PAR2 GO Gene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

dGene: F2RL1

Alternate Names: 2150 Gene ID GPR11 dGene Synonym PAR2 dGene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

Pharos: F2RL1

Alternate Names: Proteinase-activated receptor 2 Gene Name P55085 UniProt ID

Gene Info:

Gene Categories: KINASE, ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18720984

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

PMIDs:
18720984

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19258275

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18212111

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19258275

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18212111

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19258275

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18212111

Sources:
DTC

Alternate Names:

F2RL1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PROTEINASE-ACTIVATED RECEPTOR 2, ALTERNATE CLEAVED 1 Uniprot Protein Name

ENSG00000164251 Ensembl Gene Id

2150 Entrez Gene Id

Gene Info:

Interpro Acc IPR000276

Interpro Type Family

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

ENSG00000164251 Ensembl Gene Id

F2RL1 Display Id

PROTEINASE ACTIVATED RECEPTOR 2 PRECURSOR (PAR-2) (THROMBIN RECEPTOR- LIKE 1) (COAGULATION FACTOR II RECEPTOR-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55085] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.

Alternate Names:

ENSG00000164251 Gene Symbol

F2RL1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GPR11 GO Gene Synonym

PAR2 GO Gene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

2150 Gene ID

GPR11 dGene Synonym

PAR2 dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

Proteinase-activated receptor 2 Gene Name

P55085 UniProt ID

Gene Categories:

KINASE, ENZYME