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F2RL1 Gene Record

  • Summary
  • Interactions
  • Claims
  • F2RL1 2150 Druggable Genome

    Alternate Names:

    2150
    F2R LIKE TRYPSIN RECEPTOR 1
    F2RL1
    GPR11
    PAR2
    600933
    3538
    ENSG00000164251
    OTTHUMG00000102118
    PAR2_HUMAN
    P55085
    PROTEINASE-ACTIVATED RECEPTOR 2, ALTERNATE CLEAVED 1
    PROTEINASE ACTIVATED RECEPTOR 2 PRECURSOR (PAR-2) (THROMBIN RECEPTOR- LIKE 1) (COAGULATION FACTOR II RECEPTOR-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55085]
    Proteinase-activated receptor 2

    Gene Info:

    Interpro Acc IPR000276
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.
    Seitzberg JG et al., 2008, Discovery of potent and selective small-molecule PAR-2 agonists., J Med Chem
    Ishikawa C et al., 2009, Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes., Antimicrob Agents Chemother
  • CHEMBL494502   F2RL1

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18720984


    Sources:
    DTC

  • CHEMBL493076   F2RL1

    Interaction Score: 15.46

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    18720984


    Sources:
    DTC

  • MINOCYCLINE   F2RL1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19258275


    Sources:
    DTC

  • ROXITHROMYCIN   F2RL1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18212111


    Sources:
    DTC

  • DOXYCYCLINE   F2RL1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19258275


    Sources:
    DTC

  • CLARITHROMYCIN   F2RL1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18212111


    Sources:
    DTC

  • TETRACYCLINE   F2RL1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19258275


    Sources:
    DTC

  • ERYTHROMYCIN   F2RL1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18212111


    Sources:
    DTC

  • Ensembl: ENSG00000164251

    • Version: 101_38

    Alternate Names:
    F2RL1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P55085

    • Version: 11-September-2012

    Alternate Names:
    PROTEINASE-ACTIVATED RECEPTOR 2, ALTERNATE CLEAVED 1 Uniprot Protein Name
    ENSG00000164251 Ensembl Gene Id
    2150 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR000276
    Interpro Type Family
    Uniprot Status Swiss-Prot

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000164251

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000164251 Ensembl Gene Id
    F2RL1 Display Id
    PROTEINASE ACTIVATED RECEPTOR 2 PRECURSOR (PAR-2) (THROMBIN RECEPTOR- LIKE 1) (COAGULATION FACTOR II RECEPTOR-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P55085] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: F2RL1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.

  • DTC: F2RL1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Tsuda et al., 2008, Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated receptor 2 in human keratinocytes., Antimicrob. Agents Chemother.
    Ishikawa C et al., 2009, Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes., Antimicrob Agents Chemother
    Seitzberg JG et al., 2008, Discovery of potent and selective small-molecule PAR-2 agonists., J Med Chem

  • HingoraniCasas: ENSG00000164251

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164251 Gene Symbol
    F2RL1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: F2RL1

    • Version: 01-February-2022

    Alternate Names:
    GPR11 GO Gene Synonym
    PAR2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: F2RL1

    • Version: 27-Jun-2013

    Alternate Names:
    2150 Gene ID
    GPR11 dGene Synonym
    PAR2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • Pharos: F2RL1

    • Version: 01-February-2022

    Alternate Names:
    Proteinase-activated receptor 2 Gene Name
    P55085 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21