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F2 Gene Record

  • Summary
  • Interactions
  • Claims
  • F2 2147 Druggable Genome

    Alternate Names:

    2147
    COAGULATION FACTOR II, THROMBIN
    F2
    PT
    RPRGL2
    THPH1
    176930
    3535
    ENSG00000180210
    OTTHUMG00000150344
    Activation peptide fragment 1
    Prothrombin
    Activation peptide fragment 2
    Thrombin light chain
    Thrombin heavy chain
    Coagulation factor II
    P00734
    THRB_HUMAN
    PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734]
    2362
    NP_000497
    NM_000506
    BE0000048
    PA157
    Coagulation factor IIa
    T94033

    Gene Info:

    Interpro Acc IPR001254
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Peptidase_S1_S6
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Human Readable Name PROTEASE
    Target Class Enzymes
    Target Subclass EC:3.4.21.5
    Target Subclass 3.4.21.5
    Target Main Class Enzymes
    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    PROTEASE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Warkentin, 2000, Venous thromboembolism in heparin-induced thrombocytopenia., Curr Opin Pulm Med
    Fabrizio, 2001, Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass., J Extra Corpor Technol
    Turpie, 1999, Anticoagulants in acute coronary syndromes., Am. J. Cardiol.
    Szaba et al., 2002, Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo., Blood
    Eriksson, 2000, New therapeutic options in deep vein thrombosis prophylaxis., Semin. Hematol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    De Cristofaro et al., 1995, Conformational transitions linked to active site ligation in human thrombin: effect on the interaction with fibrinogen and the cleavable platelet receptor., J. Mol. Biol.
    Valeri et al., 1980, Reaction of antithrombin with proteases. Evidence for a specific reaction with papain., Biochim. Biophys. Acta
    Sonder et al., 1984, Proflavin binding within the fibrinopeptide groove adjacent to the catalytic site of human alpha-thrombin., Biochemistry
    Koehler et al., 1974, The binding of proflavin to thrombin., Arch. Biochem. Biophys.
    Sié et al., 1991, An acquired antithrombin autoantibody directed toward the catalytic center of the enzyme., J. Clin. Invest.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Jang et al., 1999, A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study., J. Am. Coll. Cardiol.
    Kawada et al., 1999, Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture., Jpn. J. Thorac. Cardiovasc. Surg.
    Serebruany et al., 1998, A Randomized, Blinded Study of Two Doses of Novastan(R) (Brand of Argatroban) Versus Heparin as Adjunctive Therapy to Recombinant Tissue Plasminogen Activator (Accelerated Administration) in Acute Myocardial Infarction: Rationale and Design of the Myocardial Infarction using Novastan(R) and T-PA (MINT) Study., J. Thromb. Thrombolysis
    Sakai et al., 1999, Argatroban as a potential anticoagulant in cardiopulmonary bypass-studies in a dog model., Cardiovasc Surg
    Matsuo et al., 1995, Effect of Thrombin Inhibition on Patients with Peripheral Arterial Obstructive Disease: A Multicenter Clinical Trial of Argatroban., J. Thromb. Thrombolysis
    Gladwell, 2002, Bivalirudin: a direct thrombin inhibitor., Clin Ther
    Kleiman et al., 2002, Pharmacodynamic profile of the direct thrombin antagonist bivalirudin given in combination with the glycoprotein IIb/IIIa antagonist eptifibatide., Am. Heart J.
    Carswell et al., 2002, Bivalirudin: a review of its potential place in the management of acute coronary syndromes., Drugs
    Bates, 2001, Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes., Curr Cardiol Rep
    Scatena, 2000, Bivalirudin: a new generation antithrombotic drug., Expert Opin Investig Drugs
    Ho et al., 2006, Ximelagatran: direct thrombin inhibitor., Vasc Health Risk Manag
    Bergqvist et al., 2004, Pharmacokinetics, preliminary efficacy and safety of subcutaneous melagatran and oral ximelagatran : a multicentre study of thromboprophylaxis in elective abdominal surgery., Clin Drug Investig
    Testa et al., 2007, The direct thrombin inhibitor ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile., Expert Opin Drug Saf
    Ersdal et al., 2005, No influence of food on the pharmacokinetics, pharmacodynamics or tolerability of the 24mg and 36mg oral tablet formulations of ximelagatran., Clin Drug Investig
    Thompson et al., 1986, Inhibition by human thrombomodulin of factor Xa-mediated cleavage of prothrombin., J. Clin. Invest.
    Casper et al., 1989, Evaluation of vitamin K3 feed additive for prevention of sweet clover disease., J. Vet. Diagn. Invest.
    Wang et al., 1995, The growth inhibitory effects of vitamins K and their actions on gene expression., Hepatology
    Szejtli et al., 1983, Preparation, properties and biological activity of beta-cyclodextrin inclusion complex of menadione., Pharmazie
    McCarthy et al., 1989, Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K., Toxicol. Appl. Pharmacol.
    Lee et al., 1999, Advantages of calcium green-1 over other fluorescent dyes in measuring cytosolic calcium in platelets., Anal. Biochem.
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Luesch H et al., 2000, Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula., J Nat Prod
    Monteiro et al., 2004, Suramin interaction with human alpha-thrombin: inhibitory effects and binding studies., Int. J. Biochem. Cell Biol.
    Turecek PL et al., 2004, FEIBA: mode of action., Haemophilia
    Tamura Y et al., 1977, Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1 esterase., Biochim Biophys Acta
    Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci
    Iwaki M et al., 1986, Pharmacological studies of FUT-175, nafamostat mesilate. V. Effects on the pancreatic enzymes and experimental acute pancreatitis in rats., Jpn J Pharmacol
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • BIVALIRUDIN   F2

    Interaction Score: 8.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name bivalirudin,Angiomax, Angiox
    Novel drug target Established target
    Specific Action of the Ligand Inhibition

    PMIDs:
    11833835 11923794 11929334 11504570 11060732 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • XIMELAGATRAN   F2

    Interaction Score: 6.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Endogenous Drug? False

    PMIDs:
    17319469 17516699 17688383 17532684 11752352


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • ARGATROBAN   F2

    Interaction Score: 3.76

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Argatroban
    Mechanism of Interaction Thrombin inhibitor

    PMIDs:
    10362188 10226408 10608050 10353669 11752352 10608016


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • CHEMBL1234081   F2

    Interaction Score: 2.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • LEPIRUDIN   F2

    Interaction Score: 2.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name lepirudin (rDNA) for injection,Refludan
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    10912644 11467439 10505536 11807012 11055889 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • CHEMBL18136   F2

    Interaction Score: 2.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • CHEMBL46780   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL401842   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL282837   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL380589   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1229851   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL125181   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL204086   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL65273   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198148   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL116597   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL379692   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL141889   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1230612   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198130   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL490730   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL100109   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL225664   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • PHENYLALANINE METHYL ESTER   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198147   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL75691   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198500   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1230016   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198191   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL321130   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL257543   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1229801   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL42039   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1229677   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL123440   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • APRAMIDE A   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10978206


    Sources:
    DTC

  • DESIRUDIN   F2

    Interaction Score: 1.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Thrombin inhibitor
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • PROFLAVINE   F2

    Interaction Score: 1.2

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    7837275 7407200 6722124 4857231 1711542 10592235


    Sources:
    DrugBank

  • CHEMBL38397   F2

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL391737   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1234624   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198138   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • GW813893   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL46148   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198650   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL391640   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL2089125   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • 4-HYDROXYPHENYLPYRUVIC ACID   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • ODIPARCIL   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL1083499   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CYANIN   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DABIGATRAN ETEXILATE MESYLATE   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thrombin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PEGMUSIRUDIN   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • THROMBOMODULIN ALFA   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    3013935


    Sources:
    DrugBank

  • CHEMBL586628   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYANIDIN   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ATECEGATRAN METOXIL   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name AZD-0837

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AZD-8165   F2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL1234619   F2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL96433   F2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL327715   F2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • DABIGATRAN   F2

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Binding affinity to human thrombin.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial TTD GuideToPharmacology ChemblInteractions

  • CHEMBL290376   F2

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Details of the Assay for Interaction Affinity for thrombin active site.
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GABEXATE   F2

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    143965


    Sources:
    DrugBank

  • LUSUTROMBOPAG   F2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA PharmGKB

  • MELAGATRAN   F2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • ANTI-INHIBITOR COAGULANT COMPLEX   F2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    15385040


    Sources:
    DrugBank

  • ENOXAPARIN   F2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Lovenox
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MENADIONE   F2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    2484931 7657295 6867080 2922761 10469489


    Sources:
    TEND DrugBank

  • AVATROMBOPAG   F2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA PharmGKB

  • ANISINDIONE   F2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MENADIOL SODIUM DIPHOSPHATE   F2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CIANIDANOL   F2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NAFAMOSTAT   F2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    2427760


    Sources:
    DrugBank

  • (-)-EPICATECHIN   F2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SILIBININ   F2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HEPARIN   F2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name octaparine, AVE-5026
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • SURAMIN   F2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15203120


    Sources:
    DrugBank

  • TAMOXIFEN   F2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA PharmGKB

  • BORTEZOMIB   F2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC

  • COPPER   F2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • METHYLDOPA   F2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23896426


    Sources:
    DrugBank

  • QUERCETIN   F2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000180210

    • Version: 101_38

    Alternate Names:
    F2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P00734

    • Version: 11-September-2012

    Alternate Names:
    THRB_HUMAN Uniprot Id
    PROTHROMBIN Uniprot Protein Name
    P00734 Uniprot Accession

    Gene Info:
    Interpro Acc IPR001254
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000180210

    • Version: 26-July-2011

    Alternate Names:
    PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734] Description
    F2 Display Id
    ENSG00000180210 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P00734

    • Version: January-2014

    Alternate Names:
    F2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.5

    Publications:

  • TEND: P00734

    • Version: 01-August-2011

    Alternate Names:
    2147 Entrez Gene Id
    F2 Gene Symbol
    ENSG00000180210 Ensembl Gene Id

    Gene Info:
    Target Subclass 3.4.21.5
    Target Main Class Enzymes

    Publications:

  • GuideToPharmacology: 2147

    • Version: 29-September-2020

    Alternate Names:
    3535 HUGO Gene ID
    3535 HUGO Gene Symbol
    coagulation factor II, thrombin HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: F2

    • Version: 18-August-2020

    Alternate Names:
    PA157 PharmGKB ID

    Gene Info:

    Publications:
    Sidney S et al., 2004, Venous thromboembolic disease in users of low-estrogen combined estrogen-progestin oral contraceptives., Contraception
    McDaid A et al., 2017, Risk prediction of developing venous thrombosis in combined oral contraceptive users., PLoS One
    Legnani C et al., 2002, Venous thromboembolism in young women; role of thrombophilic mutations and oral contraceptive use., Eur Heart J

  • DrugBank: BE0000048

    • Version: 5.1.7

    Alternate Names:
    F2 DrugBank Gene Name
    P00734 UniProt Accession
    2147 Entrez Gene Id

    Gene Info:

    Publications:
    Warkentin, 2000, Venous thromboembolism in heparin-induced thrombocytopenia., Curr Opin Pulm Med
    Fabrizio, 2001, Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass., J Extra Corpor Technol
    Turpie, 1999, Anticoagulants in acute coronary syndromes., Am. J. Cardiol.

  • TTD: Coagulation factor IIa

    • Version: 2020.06.01

    Alternate Names:
    F2 TTD Gene Abbreviation
    T94033 TTD Target ID

    Gene Info:

    Publications:
    Salas CM et al., 2013, Antithrombin III Utilization in a Large Teaching Hospital., P T
    Ni X et al., 2011, Nucleic acid aptamers: clinical applications and promising new horizons., Curr Med Chem

  • DTC: F2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Luesch H et al., 2000, Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula., J Nat Prod
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

  • ChemblInteractions: F2

    • Version: chembl_23

    Alternate Names:
    F2 GENE_SYMBOL
    Prothrombin UNIPROT
    Activation peptide fragment 1 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000180210

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000180210 Gene Symbol
    F2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: F2

    • Version: 27-Jun-2013

    Alternate Names:
    2147 Gene ID
    PT dGene Synonym
    RPRGL2 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • FDA: F2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • GO: F2

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    GROWTH FACTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21