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F2 2147 Druggable Genome
Alternate Names:
2147 COAGULATION FACTOR II, THROMBIN F2 PT RPRGL2 THPH1 176930 3535 ENSG00000180210 OTTHUMG00000150344 Activation peptide fragment 1 Prothrombin Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain Coagulation factor II P00734 THRB_HUMAN PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734] 2362 NP_000497 NM_000506 PA157 Coagulation factor IIa T94033 Gene Info:
Interpro Acc IPR001254 Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Interpro Short Name Peptidase_S1_S6 Interpro Name Peptidase S1/S6, chymotrypsin/Hap Interpro Type Domain Uniprot Status Swiss-Prot Human Readable Name PROTEASE Target Class Enzymes Target Subclass EC:3.4.21.5 Target Subclass 3.4.21.5 Target Main Class Enzymes GuideToPharmacology Gene Category Name S1: Chymotrypsin GuideToPharmacology Gene Category ID 751 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
GROWTH FACTOR PROTEASE EXTERNAL SIDE OF PLASMA MEMBRANE DRUGGABLE GENOME ENZYME Publications:
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Interaction Score: 23.39
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name bivalirudin,Angiomax, Angiox Novel drug target Established target Specific Action of the Ligand Inhibition -
Interaction Score: 17.01
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name - Novel drug target Established target Endogenous Drug? False
Sources:
TdgClinicalTrial TEND GuideToPharmacology -
Interaction Score: 10.63
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Novel drug target Established target Trial Name Argatroban Mechanism of Interaction Thrombin inhibitor -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name lepirudin (rDNA) for injection,Refludan Novel drug target Established target Direct Interaction yes -
Interaction Score: 4.25
-
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Thrombin inhibitor Specific Action of the Ligand Inhibition -
Interaction Score: 2.13
-
Interaction Score: 2.13
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Thrombin inhibitor Direct Interaction yes -
Interaction Score: 2.13
-
Interaction Score: 2.13
-
Interaction Score: 2.13
Interaction Types & Directionality:
n/a Interaction Info:
Novel drug target Established target Trial Name AZD-0837 -
Interaction Score: 1.18
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Details of the Assay for Interaction Binding affinity to human thrombin. Specific Action of the Ligand Inhibition Endogenous Drug? False -
Interaction Score: 1.06
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Endogenous Drug? False Details of the Assay for Interaction Affinity for thrombin active site. Specific Action of the Ligand Inhibition -
Interaction Score: 0.71
-
Interaction Score: 0.71
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name Lovenox Novel drug target Established target -
Interaction Score: 0.71
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition -
Interaction Score: 0.61
-
Interaction Score: 0.35
-
Interaction Score: 0.3
-
Interaction Score: 0.19
-
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name octaparine, AVE-5026 Novel drug target Established target -
Interaction Score: 0.05
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- Version: 101_38
Alternate Names:
F2 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
-
- Version: 11-September-2012
Alternate Names:
THRB_HUMAN Uniprot Id PROTHROMBIN Uniprot Protein Name P00734 Uniprot Accession Gene Info:
Interpro Acc IPR001254 Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Gene Categories:
PROTEASE, DRUGGABLE GENOME Publications:
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- Version: 26-July-2011
Alternate Names:
PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734] Description F2 Display Id ENSG00000180210 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
F2 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:3.4.21.5 Publications:
-
Alternate Names:
2147 Entrez Gene Id F2 Gene Symbol ENSG00000180210 Ensembl Gene Id Gene Info:
Target Subclass 3.4.21.5 Target Main Class Enzymes Publications:
-
- Version: 29-September-2020
Alternate Names:
3535 HUGO Gene ID 3535 HUGO Gene Symbol coagulation factor II, thrombin HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name S1: Chymotrypsin GuideToPharmacology Gene Category ID 751 Gene Categories:
ENZYME Publications:
-
Alternate Names:
PA157 PharmGKB ID Gene Info:
Publications:
-
- Version: 2020.06.01
Alternate Names:
F2 TTD Gene Abbreviation T94033 TTD Target ID Gene Info:
-
Alternate Names:
Gene Info:
Publications:
-
- Version: chembl_23
Alternate Names:
F2 GENE_SYMBOL Prothrombin UNIPROT Activation peptide fragment 1 UNIPROT Gene Info:
Publications:
-
- Version: 31-May-2017
Alternate Names:
ENSG00000180210 Gene Symbol F2 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
-
Alternate Names:
2147 Gene ID PT dGene Synonym RPRGL2 dGene Synonym Gene Info:
Gene Categories:
PROTEASE Publications:
-
Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
GROWTH FACTOR, EXTERNAL SIDE OF PLASMA MEMBRANE Publications: