DGIdb - F2 Gene Record

F2 2147 Druggable Genome

Alternate Names:

2147
COAGULATION FACTOR II, THROMBIN
F2
PT
RPRGL2
THPH1
176930
3535
ENSG00000180210
OTTHUMG00000150344
Activation peptide fragment 1
Prothrombin
Activation peptide fragment 2
Thrombin light chain
Thrombin heavy chain
Coagulation factor II
P00734
THRB_HUMAN
PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734]
2362
NP_000497
NM_000506
BE0000048
PA157
Coagulation factor IIa
T94033

Gene Info:

Interpro Acc	IPR001254
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Peptidase_S1_S6
Interpro Name	Peptidase S1/S6, chymotrypsin/Hap
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Human Readable Name	PROTEASE
Target Class	Enzymes
Target Subclass	EC:3.4.21.5
Target Subclass	3.4.21.5
Target Main Class	Enzymes
GuideToPharmacology Gene Category Name	S1: Chymotrypsin
GuideToPharmacology Gene Category ID	751
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
PROTEASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
ENZYME

Publications:

Warkentin, 2000, Venous thromboembolism in heparin-induced thrombocytopenia., Curr Opin Pulm Med
Fabrizio, 2001, Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass., J Extra Corpor Technol
Turpie, 1999, Anticoagulants in acute coronary syndromes., Am. J. Cardiol.
Szaba et al., 2002, Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo., Blood
Eriksson, 2000, New therapeutic options in deep vein thrombosis prophylaxis., Semin. Hematol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
De Cristofaro et al., 1995, Conformational transitions linked to active site ligation in human thrombin: effect on the interaction with fibrinogen and the cleavable platelet receptor., J. Mol. Biol.
Valeri et al., 1980, Reaction of antithrombin with proteases. Evidence for a specific reaction with papain., Biochim. Biophys. Acta
Sonder et al., 1984, Proflavin binding within the fibrinopeptide groove adjacent to the catalytic site of human alpha-thrombin., Biochemistry
Koehler et al., 1974, The binding of proflavin to thrombin., Arch. Biochem. Biophys.
Sié et al., 1991, An acquired antithrombin autoantibody directed toward the catalytic center of the enzyme., J. Clin. Invest.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Jang et al., 1999, A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study., J. Am. Coll. Cardiol.
Kawada et al., 1999, Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture., Jpn. J. Thorac. Cardiovasc. Surg.
Serebruany et al., 1998, A Randomized, Blinded Study of Two Doses of Novastan(R) (Brand of Argatroban) Versus Heparin as Adjunctive Therapy to Recombinant Tissue Plasminogen Activator (Accelerated Administration) in Acute Myocardial Infarction: Rationale and Design of the Myocardial Infarction using Novastan(R) and T-PA (MINT) Study., J. Thromb. Thrombolysis
Sakai et al., 1999, Argatroban as a potential anticoagulant in cardiopulmonary bypass-studies in a dog model., Cardiovasc Surg
Matsuo et al., 1995, Effect of Thrombin Inhibition on Patients with Peripheral Arterial Obstructive Disease: A Multicenter Clinical Trial of Argatroban., J. Thromb. Thrombolysis
Gladwell, 2002, Bivalirudin: a direct thrombin inhibitor., Clin Ther
Kleiman et al., 2002, Pharmacodynamic profile of the direct thrombin antagonist bivalirudin given in combination with the glycoprotein IIb/IIIa antagonist eptifibatide., Am. Heart J.
Carswell et al., 2002, Bivalirudin: a review of its potential place in the management of acute coronary syndromes., Drugs
Bates, 2001, Bivalirudin for percutaneous coronary intervention and in acute coronary syndromes., Curr Cardiol Rep
Scatena, 2000, Bivalirudin: a new generation antithrombotic drug., Expert Opin Investig Drugs
Ho et al., 2006, Ximelagatran: direct thrombin inhibitor., Vasc Health Risk Manag
Bergqvist et al., 2004, Pharmacokinetics, preliminary efficacy and safety of subcutaneous melagatran and oral ximelagatran : a multicentre study of thromboprophylaxis in elective abdominal surgery., Clin Drug Investig
Testa et al., 2007, The direct thrombin inhibitor ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile., Expert Opin Drug Saf
Ersdal et al., 2005, No influence of food on the pharmacokinetics, pharmacodynamics or tolerability of the 24mg and 36mg oral tablet formulations of ximelagatran., Clin Drug Investig
Thompson et al., 1986, Inhibition by human thrombomodulin of factor Xa-mediated cleavage of prothrombin., J. Clin. Invest.
Casper et al., 1989, Evaluation of vitamin K3 feed additive for prevention of sweet clover disease., J. Vet. Diagn. Invest.
Wang et al., 1995, The growth inhibitory effects of vitamins K and their actions on gene expression., Hepatology
Szejtli et al., 1983, Preparation, properties and biological activity of beta-cyclodextrin inclusion complex of menadione., Pharmazie
McCarthy et al., 1989, Retinoid-induced hemorrhaging and bone toxicity in rats fed diets deficient in vitamin K., Toxicol. Appl. Pharmacol.
Lee et al., 1999, Advantages of calcium green-1 over other fluorescent dyes in measuring cytosolic calcium in platelets., Anal. Biochem.
Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
Luesch H et al., 2000, Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula., J Nat Prod
Monteiro et al., 2004, Suramin interaction with human alpha-thrombin: inhibitory effects and binding studies., Int. J. Biochem. Cell Biol.
Turecek PL et al., 2004, FEIBA: mode of action., Haemophilia
Tamura Y et al., 1977, Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1 esterase., Biochim Biophys Acta
Wang F et al., 2013, Immobilized metal affinity chromatography and human serum proteomics., J Chromatogr B Analyt Technol Biomed Life Sci
Iwaki M et al., 1986, Pharmacological studies of FUT-175, nafamostat mesilate. V. Effects on the pancreatic enzymes and experimental acute pancreatitis in rats., Jpn J Pharmacol
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

BIVALIRUDIN F2

Interaction Score: 8.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name bivalirudin,Angiomax, Angiox

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
11833835 11923794 11929334 11504570 11060732 11752352

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
XIMELAGATRAN F2

Interaction Score: 6.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Endogenous Drug? False

PMIDs:
17319469 17516699 17688383 17532684 11752352

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
ARGATROBAN F2

Interaction Score: 3.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Argatroban

Mechanism of Interaction Thrombin inhibitor

PMIDs:
10362188 10226408 10608050 10353669 11752352 10608016

Sources:
TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
CHEMBL1234081 F2

Interaction Score: 2.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
LEPIRUDIN F2

Interaction Score: 2.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name lepirudin (rDNA) for injection,Refludan

Novel drug target Established target

Direct Interaction yes

PMIDs:
10912644 11467439 10505536 11807012 11055889 11752352

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
CHEMBL18136 F2

Interaction Score: 2.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL46780 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL401842 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL282837 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL380589 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1229851 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL125181 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL204086 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL65273 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198148 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL116597 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL379692 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL141889 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1230612 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198130 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL490730 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL100109 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL225664 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
PHENYLALANINE METHYL ESTER F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198147 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL75691 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198500 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1230016 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198191 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL321130 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL257543 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1229801 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL42039 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1229677 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL123440 F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
APRAMIDE A F2

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10978206

Sources:
DTC
DESIRUDIN F2

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Thrombin inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
PROFLAVINE F2

Interaction Score: 1.2

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
7837275 7407200 6722124 4857231 1711542 10592235

Sources:
DrugBank
CHEMBL38397 F2

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL391737 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1234624 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198138 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
GW813893 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL46148 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198650 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL391640 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL2089125 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
4-HYDROXYPHENYLPYRUVIC ACID F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
ODIPARCIL F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1083499 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CYANIN F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DABIGATRAN ETEXILATE MESYLATE F2

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thrombin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PEGMUSIRUDIN F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
THROMBOMODULIN ALFA F2

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
3013935

Sources:
DrugBank
CHEMBL586628 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYANIDIN F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ATECEGATRAN METOXIL F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name AZD-0837

PMIDs:
None found

Sources:
TdgClinicalTrial
AZD-8165 F2

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1234619 F2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL96433 F2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL327715 F2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
DABIGATRAN F2

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Binding affinity to human thrombin.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TEND TdgClinicalTrial TTD GuideToPharmacology ChemblInteractions
CHEMBL290376 F2

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Details of the Assay for Interaction Affinity for thrombin active site.

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
GABEXATE F2

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
143965

Sources:
DrugBank
LUSUTROMBOPAG F2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
MELAGATRAN F2

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TTD GuideToPharmacology
ANTI-INHIBITOR COAGULANT COMPLEX F2

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
15385040

Sources:
DrugBank
ENOXAPARIN F2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Lovenox

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MENADIONE F2

Interaction Score: 0.17

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
2484931 7657295 6867080 2922761 10469489

Sources:
TEND DrugBank
AVATROMBOPAG F2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
ANISINDIONE F2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MENADIOL SODIUM DIPHOSPHATE F2

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
CIANIDANOL F2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NAFAMOSTAT F2

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
2427760

Sources:
DrugBank
(-)-EPICATECHIN F2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SILIBININ F2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HEPARIN F2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name octaparine, AVE-5026

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
SURAMIN F2

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15203120

Sources:
DrugBank
TAMOXIFEN F2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
BORTEZOMIB F2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20875739

Sources:
DTC
COPPER F2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23896426

Sources:
DrugBank
METHYLDOPA F2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23896426

Sources:
DrugBank
QUERCETIN F2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000180210
- Version: 101_38
Alternate Names:

F2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P00734
- Version: 11-September-2012
Alternate Names:

THRB_HUMAN Uniprot Id

PROTHROMBIN Uniprot Protein Name

P00734 Uniprot Accession

Gene Info:

Interpro Acc IPR001254

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000180210
- Version: 26-July-2011
Alternate Names:

PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734] Description

F2 Display Id

ENSG00000180210 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P00734
- Version: January-2014
Alternate Names:

F2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.21.5

Publications:
TEND: P00734
- Version: 01-August-2011
Alternate Names:

2147 Entrez Gene Id

F2 Gene Symbol

ENSG00000180210 Ensembl Gene Id

Gene Info:

Target Subclass 3.4.21.5

Target Main Class Enzymes

Publications:
GuideToPharmacology: 2147
- Version: 29-September-2020
Alternate Names:

3535 HUGO Gene ID

3535 HUGO Gene Symbol

coagulation factor II, thrombin HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name S1: Chymotrypsin

GuideToPharmacology Gene Category ID 751

Gene Categories:

ENZYME

Publications:

PharmGKB: F2

Version: 18-August-2020

Alternate Names:

PA157 PharmGKB ID

Gene Info:

Publications:

Sidney S et al., 2004, Venous thromboembolic disease in users of low-estrogen combined estrogen-progestin oral contraceptives., Contraception

McDaid A et al., 2017, Risk prediction of developing venous thrombosis in combined oral contraceptive users., PLoS One

Legnani C et al., 2002, Venous thromboembolism in young women; role of thrombophilic mutations and oral contraceptive use., Eur Heart J

DrugBank: BE0000048

Version: 5.1.7

Alternate Names:

F2 DrugBank Gene Name

P00734 UniProt Accession

2147 Entrez Gene Id

Gene Info:

Publications:

Warkentin, 2000, Venous thromboembolism in heparin-induced thrombocytopenia., Curr Opin Pulm Med

Fabrizio, 2001, Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass., J Extra Corpor Technol

Turpie, 1999, Anticoagulants in acute coronary syndromes., Am. J. Cardiol.

TTD: Coagulation factor IIa

Version: 2020.06.01

Alternate Names:

F2 TTD Gene Abbreviation

T94033 TTD Target ID

Gene Info:

Publications:

Salas CM et al., 2013, Antithrombin III Utilization in a Large Teaching Hospital., P T

Ni X et al., 2011, Nucleic acid aptamers: clinical applications and promising new horizons., Curr Med Chem

DTC: F2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Luesch H et al., 2000, Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula., J Nat Prod

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

ChemblInteractions: F2
- Version: chembl_23
Alternate Names:

F2 GENE_SYMBOL

Prothrombin UNIPROT

Activation peptide fragment 1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000180210
- Version: 31-May-2017
Alternate Names:

ENSG00000180210 Gene Symbol

F2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: F2
- Version: 27-Jun-2013
Alternate Names:

2147 Gene ID

PT dGene Synonym

RPRGL2 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
FDA: F2
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:
GO: F2
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

GROWTH FACTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Trial Name	bivalirudin,Angiomax, Angiox
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Trial Name	lepirudin (rDNA) for injection,Refludan
Novel drug target	Established target
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Thrombin inhibitor
Specific Action of the Ligand	Inhibition

Details of the Assay for Interaction	Binding affinity to human thrombin.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Trial Name	octaparine, AVE-5026
Novel drug target	Established target

THRB_HUMAN	Uniprot Id
PROTHROMBIN	Uniprot Protein Name
P00734	Uniprot Accession

PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734]	Description
F2	Display Id
ENSG00000180210	Ensembl Gene Id

2147	Entrez Gene Id
F2	Gene Symbol
ENSG00000180210	Ensembl Gene Id

3535	HUGO Gene ID
3535	HUGO Gene Symbol
coagulation factor II, thrombin	HUGO Gene Name

F2	DrugBank Gene Name
P00734	UniProt Accession
2147	Entrez Gene Id

F2	GENE_SYMBOL
Prothrombin	UNIPROT
Activation peptide fragment 1	UNIPROT

F2 Gene Record

F2 2147 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name bivalirudin,Angiomax, Angiox Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 11833835 11923794 11929334 11504570 11060732 11752352

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Endogenous Drug? False

PMIDs: 17319469 17516699 17688383 17532684 11752352

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Argatroban Mechanism of Interaction Thrombin inhibitor

PMIDs: 10362188 10226408 10608050 10353669 11752352 10608016

Sources: TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name lepirudin (rDNA) for injection,Refludan Novel drug target Established target Direct Interaction yes

PMIDs: 10912644 11467439 10505536 11807012 11055889 11752352

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name bivalirudin,Angiomax, Angiox

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
11833835 11923794 11929334 11504570 11060732 11752352

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Endogenous Drug? False

PMIDs:
17319469 17516699 17688383 17532684 11752352

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Argatroban

Mechanism of Interaction Thrombin inhibitor

PMIDs:
10362188 10226408 10608050 10353669 11752352 10608016

Sources:
TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name lepirudin (rDNA) for injection,Refludan

Novel drug target Established target

Direct Interaction yes

PMIDs:
10912644 11467439 10505536 11807012 11055889 11752352

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a