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F12 Gene Record

  • Summary
  • Interactions
  • Claims
  • F12 2161 Druggable Genome

    Alternate Names:

    2161
    COAGULATION FACTOR XII
    F12
    HAE3
    HAEX
    HAF
    610619
    3530
    ENSG00000131187
    OTTHUMG00000163403
    BE0004672
    P00748
    2361
    COAGULATION FACTOR XII PRECURSOR (EC 3.4.21.38) (HAGEMAN FACTOR) (HAF). [SOURCE:UNIPROT/SWISSPROT;ACC:P00748]
    NP_000496
    NM_000505
    FA12_HUMAN
    COAGULATION FACTOR XIIA LIGHT CHAIN
    PA161

    Gene Info:

    Human Readable Name PROTEASE
    Target Class Enzymes
    Target Subclass EC:3.4.21.38
    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Short Name Peptidase_S1_S6
    Interpro Acc IPR001254
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Baek NN et al., 2012, The role of nafamostat mesylate in continuous renal replacement therapy among patients at high risk of bleeding., Ren Fail
    Røjkaer R et al., 1997, Partial identification of the Zn2+-binding sites in factor XII and its activation derivatives., Eur J Biochem
  • PENTAMIDINE ISETHIONATE   F12

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NAFAMOSTAT   F12

    Interaction Score: 1.78

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22251267


    Sources:
    DrugBank

  • BORTEZOMIB   F12

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC

  • METHYLDOPA   F12

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9266689


    Sources:
    DrugBank

  • Ensembl: ENSG00000131187

    • Version: 101_38

    Alternate Names:
    F12 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P00748

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000131187 Ensembl Gene Id
    FA12_HUMAN Uniprot Id
    COAGULATION FACTOR XIIA LIGHT CHAIN Uniprot Protein Name

    Gene Info:
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000131187

    • Version: 26-July-2011

    Alternate Names:
    F12 Display Id
    ENSG00000131187 Ensembl Gene Id
    COAGULATION FACTOR XII PRECURSOR (EC 3.4.21.38) (HAGEMAN FACTOR) (HAF). [SOURCE:UNIPROT/SWISSPROT;ACC:P00748] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P00748

    • Version: January-2014

    Alternate Names:
    F12 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.38

    Publications:

  • GuideToPharmacology: 2161

    • Version: 29-September-2020

    Alternate Names:
    3530 HUGO Gene ID
    3530 HUGO Gene Symbol
    coagulation factor XII HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: F12

    • Version: 18-August-2020

    Alternate Names:
    PA161 PharmGKB ID

    Gene Info:

    Publications:
    del Río-Espínola A et al., 2012, A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke., Ann Neurol

  • DrugBank: BE0004672

    • Version: 5.1.7

    Alternate Names:
    F12 DrugBank Gene Name
    P00748 UniProt Accession
    2161 Entrez Gene Id

    Gene Info:

    Publications:
    de Agostini et al., 1984, Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor., J. Clin. Invest.
    Kang et al., 1987, Mechanism of the haemostatic effect of ethanolamine oleate in the injection sclerotherapy for oesophageal varices., Br J Surg
    Takada et al., 1991, Changes in thrombin-antithrombin III complex after endoscopic injection sclerotherapy., Am. J. Gastroenterol.

  • DTC: F12

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000131187

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000131187 Gene Symbol
    F12 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: F12

    • Version: 27-Jun-2013

    Alternate Names:
    2161 Gene ID
    HAE3 dGene Synonym
    HAEX dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21